Bauer, M.

Emmert, D.

Hofmann, G. G.

Horn, K.

Pickardt, C. R.

Scriba, Peter Christian

English

Open Access LMU

endocrino bgiea Supplementum 212 Advance Abstracts of Papers Xlth Acta Endocrinologica Congress Lausanne 19th-23rd June, 1977 PERIODICA · COPENHAGEN 1977 CONTENTS page PLENARY LECTURES 1 A b s t r a c t s SYMPOSIA R e g u l a t i o n o f t h e E n d o c r i n e P a n c r e a s by G a s t r o i n t e s t i n a l Hormones Symposium 1 A b s t r a c t s S 1 - S 5 8 I n i t i a t i o n o f P u b e r t y Symposium 2 A b s t r a c t s S 6 - S 10 11 Monoaminergic and C h o l i n e r g i c I n f l u e n c e s on Hormone S e c r e t i o n Symposium 3 A b s t r a c t s S 11 - S 15 13 P r o l a c t i n and Human R e p r o d u c t i o n Symposium 4 A b s t r a c t s S 16 - S 21 16 Growth F a c t o r s (NSILA, Somatomedins) and Growth Hormone Symposium 5 A b s t r a c t s S 22 - S 25 20 The M a i n t e n a n c e o f C a l c i u m H o m e o s t a s i s Symposium 6 A b s t r a c t s S 26 - S 28 22 F R E f COMMUNICATIONS Mc*le Gonads S e s s i o n 1 A b s t r a c t s 1 - 1 0 26 Pr e g n a n c y , L a c t a t i o n S e s s i o n 2 A b s t r a c t s 11 - 20 31 Mode o f A c t i o n o f Hormones S e s s i o n 4 A b s t r a c t s 21 - 30 36 VII page M e n s t r u a l C y c l e S e s s i o n 7 A b s t r a c t s 31 - 40 41 T a r g e t T i s s u e s o f Sex Hormones S e s s i o n 10 A b s t r a c t s 41 - 50 46 P r o l a c t i n S e s s i o n 14 A b s t r a c t s 51 - 60 51 G o n a d o t r o p h i n R e g u l a t i o n I S e s s i o n 15 A b s t r a c t s 6 1 - 7 0 56 G o n a d o t r o p h i n R e g u l a t i o n I I S e s s i o n 16 A b s t r a c t s 71 - 80 61 Sex S t e r o i d M e t a b o l i s m S e s s i o n 17 A b s t r a c t s 81 - 90 66 N e u r o e n d o c r i n o l o g y S e s s i o n 13 A b s t r a c t s 91 - 100 71 P i t u i t a r y S e s s i o n 3 A b s t r a c t s 101 - 110 76 T h y r o i d S e s s i o n 5 A b s t r a c t s 111 - 120 81 A d r e n a l C o r t e x S e s s i o n 8 A b s t r a c t s 121 - 130 86 A l d o s t e r o n e , H y p e r t e n s i o n S e s s i o n 18 A b s t r a c t s 131 - 140 91 Growth Hormone, Growth F a c t o r s S e s s i o n 9 A b s t r a c t s 141 - 150 96 E n d o c r i n e P a n c r e a s S e s s i o n 12 A b s t r a c t s 151 - 155 101 VIII page G a s t r o i n t e s t i n a l Hormones S e s s i o n 6 A b s t r a c t s 156 - 165 103 C a l c i u m M e t a b o l i s m S e s s i o n 11 A b s t r a c t s 166 - 170 108 OSTER SESSION 1. Mode o f A c t i o n o f Hormones A b s t r a c t s 171 - 180 2. Male Gonads A b s t r a c t s 181 - 188 3. M e n s t r u a l C y c l e A b s t r a c t s 189 - 197 4. Pregnancy and L a c t a t i o n A b s t r a c t s 198 - 209 5. G o n a d o t r o p h i n R e g u l a t i o n A b s t r a c t s 210 - 224 6. P r o l a c t i n A b s t r a c t s 225 - 238 7. T a r g e t T i s s u e s o f Sex Hormones A b s t r a c t s 239 - 244 8. S e x S t e r o i d M e t a b o l i s m A b s t r a c t s 245 - 255 9. N e u r o e n d o c r i n o l o g y A b s t r a c t s 256 - 265 10. P i t u i t a r y A b s t r a c t s 266 - 280 11. T h y r o i d A b s t r a c t s 281 - 298 12. A d r e n a l C o r t e x A b s t r a c t s 299 - 307 13. A l d o s t e r o n e , H y p e r t e n s i o n A b s t r a c t s 308 - 318 14. Growth F a c t o r s A b s t r a c t s 319 - 326 112 117 121 125 131 139 146 149 154 159 167 176 180 186 IY 15. E n d o c r i n e P a n c r e a s A b s t r a c t s 327 - 334 16. G a s t r o i n t e s t i n a l Hormones A b s t r a c t s 335 - 341 17. C a l c i u m M e t a b o l i s m A b s t r a c t s 342 - 347 18. Methods A b s t r a c t s 348 - 354 ABSTRACTS NOT PRESENTED 1. Mode of A c t i o n o f Hormones A b s t r a c t s 355 - 356 2. Male Gonads A b s t r a c t s 357 - 368 3. M e n s t r u a l C y c l e A b s t r a c t s 369 - 375 4. Pre g n a n c y and L a c t a t i o n A b s t r a c t s 376 - 379 5. G o n a d o t r o p h i n R e g u l a t i o n A b s t r a c t s 380 - 385 6. P r o l a c t i n A b s t r a c t s 386 - 387 7. T a r g e t T i s s u e s o f Sex Hormones A b s t r a c t s 388 - 390 8. Sex S t e r o i d M e t a b o l i s m A b s t r a c t s 391 - 393 9. N e u r o e n d o c r i n o l o g y A b s t r a c t s 394 - 400 10. P i t u i t a r y A b s t r a c t s 401 - 409 11. T h y r o i d A b s t r a c t s 410 - 416 12. A d r e n a l C o r t e x A b s t r a c t s 417 - 422 13. A l d o s t e r o n e , H y p e r t e n s i o n A b s t r a c t s 423 - 431 14. Growth F a c t o r s A b s t r a c t s 432 - 434 15. E n d o c r i n e P a n c r e a s A b s t r a c t s 435 - 448 16. G a s t r o i n t e s t i n a l Hormones A b s t r a c t s 449 - 453 17. C a l c i u m M e t a b o l i s m A b s t r a c t s 454 - 459 18. M i s c e l l a n e o u s A b s t r a c t s 460 - 468 1 1 9 120 THYROXINE BINDING GLOBULIN (TBG) LEVELS IN OBESE PATIENTS DIRINISHED BY TOTAL FASTING. P.C. S c r i b a , W. Bauer, D. Emmert, G.G. Hofroann, K. Horn and CR. P i c k a r d t t H e d i z i n i s c h e K l i n i k I n n e n s t a d t , U n i v e r s i t a e t Pluenchen, FRG The e f f e c t s of t o t a l f a s t i n g and of r e f e e d i n g on serum TBG l e v e l s and some parame­t e r s of t h y r o i d f u n c t i o n were s t u d i e d s e q u e n t i a l l y i n nine h o s p i t a l i z e d obese p a t i e n t s . — The f o l l o w i n g were the mean values ί SD of s i x female and t h r e e male p a t i e n t s . Age : 24 ί 8 . 5 years; % i d e a l body weight : 170 t 25 # j t o t a l f a s t i n g : 33.3 ΐ θ.5 days; w e i g h t l o s s per day : 469 ί 95 g/d; r e s t r i c t e d r e f e e d i n g , s t a r t i n g w i t h 600 Kcal per day : 18.6 t 5.8 days. R e s u l t s d u r i n g f a s t i n g t When c o r r e l a t e d w i t h the f a s t i n g t i m e , the f o l l o w i n g para­meters changed s i g n i f i c a n t l y : The TBG l e v e l s decreased, as determined by radioimmuno­assay ( r = - 0 . 4 6 1 , ρ <0 . 0 0 1 ) ; the t h y r o x i n e l e v e l s decreased i n comparison w i t h the i n d i v i d u a l i n i t i a l T4 ( r = - 0 . 3 0 2 , p< 0 . 0 1 ) . The T3 l e v e l s decreased ( RIA, r β - 0 . 3 0 9 , p < 0 . 0 5 ) . The RT3U ( r = 0 . 3 5 5 , p< 0 . 0 1 ) and f r e e f a t t y a c i d s (FFA , r a 0 . 4 3 7 , ρ< 0.01 ) i n c r e a s e d . R e s u l t s d u r i n g r e f e e d i n g : During the r e f e e d i n g t i m e , the f o l l o w i n g changes were s i g n i f i c a n t : Increas e o f a b s o l u t e l e v e l s o f TBG ( r = 0 . 4 7 3 , ρ <0 . 0 1 ) , of T4 ( r = 0 . 4 1 5 , p< 0 . 0 1 ) and o f T3-RIA ( r = 0 . 5 6 6 , p< 0 . 0 0 1 ) ; decrease of RT, U ( r = - 0 . 3 5 7 , ρ <0 . 0 5 ) and of FFA ( r = - 0 . 3 7 5 , ρ < 0.05 ) . Conclusions t 1. The i n c r e a s e of FFA d u r i n g f a s t i n g d i d not a l t e r the f T ^ index ( n . c . ) . 2 . The decrease of TBG d u r i n g f a s t i n g e x p l a i n e d the i n c r e a s e of RT3 U . 3 . D i f f e r e n c e s i n h a l f l i f e t imes may e x p l a i n the i n c r e a s e of the T4/TBG r a t i o ( r = 0 . 3 3 7 , ρ <0 . 0 5 ) d u r i n g the f a s t i n g p e r i o d , when the T3-RIA/TBG r a t i o remains c o n s t a n t ( n . c ) . 4. The increment of the response t o 200 μg TRH i . v . ( Δ TSH 30 m i n B 1 0 . 0 i 5.0 μυ/ml ) d u r i n g the r e f e e d i n g p e r i o d when compared w i t h the f a s t i n g p e r i o d ( Λ TSH = 5.2 ί 1.4 ) i s presumably neceesary t o keep the T4/TBG r a t i o c o n s t a n t ( n . c ) , when TBG l e v e l s r i s e d u r i n g r e f e e d i n g . Supported by the Deutsche Forschungsgemeinschaft ( SFB 51 ) 85 

Thyroxine binding globulin (TBG) levels in obese patients diminished by total fasting

Universität München: Elektronischen Publikationen

endocrino 
bgiea 
Supplementum 212 
Advance Abstracts 
of 
Papers 
Xlth Acta Endocrinologica Congress 
Lausanne 
19th-23rd June, 1977 
PERIODICA · COPENHAGEN 1977 
CONTENTS 
page 
PLENARY LECTURES 1 
A b s t r a c t s 
SYMPOSIA 
R e g u l a t i o n o f t h e E n d o c r i n e P a n c r e a s by 
G a s t r o i n t e s t i n a l Hormones 
Symposium 1 
A b s t r a c t s S 1 - S 5 8 
I n i t i a t i o n o f P u b e r t y 
Symposium 2 
A b s t r a c t s S 6 - S 10 11 
Monoaminergic and C h o l i n e r g i c I n f l u e n c e s on 
Hormone S e c r e t i o n 
Symposium 3 
A b s t r a c t s S 11 - S 15 13 
P r o l a c t i n and Human R e p r o d u c t i o n 
Symposium 4 
A b s t r a c t s S 16 - S 21 16 
Growth F a c t o r s (NSILA, Somatomedins) and 
Growth Hormone 
Symposium 5 
A b s t r a c t s S 22 - S 25 20 
The M a i n t e n a n c e o f C a l c i u m H o m e o s t a s i s 
Symposium 6 
A b s t r a c t s S 26 - S 28 22 
F R E f COMMUNICATIONS 
Mc*le Gonads 
S e s s i o n 1 
A b s t r a c t s 1 - 1 0 26 
Pr e g n a n c y , L a c t a t i o n 
S e s s i o n 2 
A b s t r a c t s 11 - 20 31 
Mode o f A c t i o n o f Hormones 
S e s s i o n 4 
A b s t r a c t s 21 - 30 36 
VII 
page 
M e n s t r u a l C y c l e 
S e s s i o n 7 
A b s t r a c t s 31 - 40 41 
T a r g e t T i s s u e s o f Sex Hormones 
S e s s i o n 10 
A b s t r a c t s 41 - 50 46 
P r o l a c t i n 
S e s s i o n 14 
A b s t r a c t s 51 - 60 51 
G o n a d o t r o p h i n R e g u l a t i o n I 
S e s s i o n 15 
A b s t r a c t s 6 1 - 7 0 56 
G o n a d o t r o p h i n R e g u l a t i o n I I 
S e s s i o n 16 
A b s t r a c t s 71 - 80 61 
Sex S t e r o i d M e t a b o l i s m 
S e s s i o n 17 
A b s t r a c t s 81 - 90 66 
N e u r o e n d o c r i n o l o g y 
S e s s i o n 13 
A b s t r a c t s 91 - 100 71 
P i t u i t a r y 
S e s s i o n 3 
A b s t r a c t s 101 - 110 76 
T h y r o i d 
S e s s i o n 5 
A b s t r a c t s 111 - 120 81 
A d r e n a l C o r t e x 
S e s s i o n 8 
A b s t r a c t s 121 - 130 86 
A l d o s t e r o n e , H y p e r t e n s i o n 
S e s s i o n 18 
A b s t r a c t s 131 - 140 91 
Growth Hormone, Growth F a c t o r s 
S e s s i o n 9 
A b s t r a c t s 141 - 150 96 
E n d o c r i n e P a n c r e a s 
S e s s i o n 12 
A b s t r a c t s 151 - 155 101 
VIII 
page 
G a s t r o i n t e s t i n a l Hormones 
S e s s i o n 6 
A b s t r a c t s 156 - 165 103 
C a l c i u m M e t a b o l i s m 
S e s s i o n 11 
A b s t r a c t s 166 - 170 108 
OSTER SESSION 
1. Mode o f A c t i o n o f Hormones 
A b s t r a c t s 171 - 180 
2. Male Gonads 
A b s t r a c t s 181 - 188 
3. M e n s t r u a l C y c l e 
A b s t r a c t s 189 - 197 
4. Pregnancy and L a c t a t i o n 
A b s t r a c t s 198 - 209 
5. G o n a d o t r o p h i n R e g u l a t i o n 
A b s t r a c t s 210 - 224 
6. P r o l a c t i n 
A b s t r a c t s 225 - 238 
7. T a r g e t T i s s u e s o f Sex Hormones 
A b s t r a c t s 239 - 244 
8. S e x S t e r o i d M e t a b o l i s m 
A b s t r a c t s 245 - 255 
9. N e u r o e n d o c r i n o l o g y 
A b s t r a c t s 256 - 265 
10. P i t u i t a r y 
A b s t r a c t s 266 - 280 
11. T h y r o i d 
A b s t r a c t s 281 - 298 
12. A d r e n a l C o r t e x 
A b s t r a c t s 299 - 307 
13. A l d o s t e r o n e , H y p e r t e n s i o n 
A b s t r a c t s 308 - 318 
14. Growth F a c t o r s 
A b s t r a c t s 319 - 326 
112 
117 
121 
125 
131 
139 
146 
149 
154 
159 
167 
176 
180 
186 
IY 
15. E n d o c r i n e P a n c r e a s 
A b s t r a c t s 327 - 334 
16. G a s t r o i n t e s t i n a l Hormones 
A b s t r a c t s 335 - 341 
17. C a l c i u m M e t a b o l i s m 
A b s t r a c t s 342 - 347 
18. Methods 
A b s t r a c t s 348 - 354 
ABSTRACTS NOT PRESENTED 
1. Mode of A c t i o n o f Hormones 
A b s t r a c t s 355 - 356 
2. Male Gonads 
A b s t r a c t s 357 - 368 
3. M e n s t r u a l C y c l e 
A b s t r a c t s 369 - 375 
4. Pre g n a n c y and L a c t a t i o n 
A b s t r a c t s 376 - 379 
5. G o n a d o t r o p h i n R e g u l a t i o n 
A b s t r a c t s 380 - 385 
6. P r o l a c t i n 
A b s t r a c t s 386 - 387 
7. T a r g e t T i s s u e s o f Sex Hormones 
A b s t r a c t s 388 - 390 
8. Sex S t e r o i d M e t a b o l i s m 
A b s t r a c t s 391 - 393 
9. N e u r o e n d o c r i n o l o g y 
A b s t r a c t s 394 - 400 
10. P i t u i t a r y 
A b s t r a c t s 401 - 409 
11. T h y r o i d 
A b s t r a c t s 410 - 416 
12. A d r e n a l C o r t e x 
A b s t r a c t s 417 - 422 
13. A l d o s t e r o n e , H y p e r t e n s i o n 
A b s t r a c t s 423 - 431 
14. Growth F a c t o r s 
A b s t r a c t s 432 - 434 
15. E n d o c r i n e P a n c r e a s 
A b s t r a c t s 435 - 448 
16. G a s t r o i n t e s t i n a l Hormones 
A b s t r a c t s 449 - 453 
17. C a l c i u m M e t a b o l i s m 
A b s t r a c t s 454 - 459 
18. M i s c e l l a n e o u s 
A b s t r a c t s 460 - 468 
1 1 9 
120 
THYROXINE BINDING GLOBULIN (TBG) LEVELS IN OBESE PATIENTS DIRINISHED BY TOTAL FASTING. 
P.C. S c r i b a , W. Bauer, D. Emmert, G.G. Hofroann, K. Horn and CR. P i c k a r d t t H e d i z i n i s c h e 
K l i n i k I n n e n s t a d t , U n i v e r s i t a e t Pluenchen, FRG 
The e f f e c t s of t o t a l f a s t i n g and of r e f e e d i n g on serum TBG l e v e l s and some parame­
t e r s of t h y r o i d f u n c t i o n were s t u d i e d s e q u e n t i a l l y i n nine h o s p i t a l i z e d obese p a t i e n t s . 
— The f o l l o w i n g were the mean values ί SD of s i x female and t h r e e male p a t i e n t s . 
Age : 24 ί 8 . 5 years; % i d e a l body weight : 170 t 25 # j t o t a l f a s t i n g : 33.3 ΐ θ.5 
days; w e i g h t l o s s per day : 469 ί 95 g/d; r e s t r i c t e d r e f e e d i n g , s t a r t i n g w i t h 600 Kcal 
per day : 18.6 t 5.8 days. 
R e s u l t s d u r i n g f a s t i n g t When c o r r e l a t e d w i t h the f a s t i n g t i m e , the f o l l o w i n g para­
meters changed s i g n i f i c a n t l y : The TBG l e v e l s decreased, as determined by radioimmuno­
assay ( r = - 0 . 4 6 1 , ρ <0 . 0 0 1 ) ; the t h y r o x i n e l e v e l s decreased i n comparison w i t h the 
i n d i v i d u a l i n i t i a l T4 ( r = - 0 . 3 0 2 , p< 0 . 0 1 ) . The T3 l e v e l s decreased ( RIA, 
r β - 0 . 3 0 9 , p < 0 . 0 5 ) . The RT3U ( r = 0 . 3 5 5 , p< 0 . 0 1 ) and f r e e f a t t y a c i d s (FFA , 
r a 0 . 4 3 7 , ρ< 0.01 ) i n c r e a s e d . 
R e s u l t s d u r i n g r e f e e d i n g : During the r e f e e d i n g t i m e , the f o l l o w i n g changes were 
s i g n i f i c a n t : Increas e o f a b s o l u t e l e v e l s o f TBG ( r = 0 . 4 7 3 , ρ <0 . 0 1 ) , of T4 
( r = 0 . 4 1 5 , p< 0 . 0 1 ) and o f T3-RIA ( r = 0 . 5 6 6 , p< 0 . 0 0 1 ) ; decrease of RT, U 
( r = - 0 . 3 5 7 , ρ <0 . 0 5 ) and of FFA ( r = - 0 . 3 7 5 , ρ < 0.05 ) . 
Conclusions t 1. The i n c r e a s e of FFA d u r i n g f a s t i n g d i d not a l t e r the f T ^ index 
( n . c . ) . 2 . The decrease of TBG d u r i n g f a s t i n g e x p l a i n e d the i n c r e a s e of RT3 U . 
3 . D i f f e r e n c e s i n h a l f l i f e t imes may e x p l a i n the i n c r e a s e of the T4/TBG r a t i o 
( r = 0 . 3 3 7 , ρ <0 . 0 5 ) d u r i n g the f a s t i n g p e r i o d , when the T3-RIA/TBG r a t i o remains 
c o n s t a n t ( n . c ) . 4. The increment of the response t o 200 μg TRH i . v . ( Δ TSH 30 m i n B 
1 0 . 0 i 5.0 μυ/ml ) d u r i n g the r e f e e d i n g p e r i o d when compared w i t h the f a s t i n g p e r i o d 
( Λ TSH = 5.2 ί 1.4 ) i s presumably neceesary t o keep the T4/TBG r a t i o c o n s t a n t ( n . c ) , 
when TBG l e v e l s r i s e d u r i n g r e f e e d i n g . 
Supported by the Deutsche Forschungsgemeinschaft ( SFB 51 ) 
85 


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Thyroxine binding globulin (TBG) levels in obese patients diminished by total fasting

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