Gärtner, Roland

Henze, R.

Horn, K.

Pickardt, C. R.

Scriba, Peter Christian

English

Open Access LMU

endocrino logica Supplementum 225 Advance Abstracts of Papers XII Acta Endocrinologica Congress Munich June 26-30,1979 PERIODICA • COPENHAGEN 1979 E i g e n t u m d e r M ü n c h e n GENERAL CONTENTS C o n t e n t s in de ta i l IV T i m e - T a b l e VI P o s t e r S e s s i o n s 1 - 3 5 3 S h o r t C o m m u n i c a t i o n S e s s i o n s - O r a l P r e s e n t a t i o n 3 5 4 - 4 1 3 S y m p o s i a 4 1 4 - 4 8 7 P l e n a r y L e c t u r e s 4 8 8 - 4 9 3 A n w a r d s 4 9 4 - 5 1 3 A u t h o r s ' I n d e x 5 1 5 - 5 2 7 PROGRAMME ORGANIZING COMMITTEE C h a i r m a n : J . Z a n d e r ( M ü n c h e n ) S e c r e t a r y : P. C. S c r i b a ( M ü n c h e n ) F. B i d l i n g m a i e r ( M ü n c h e n ) M. B r e c k w o l d t ( F r e i b u r g ) O. B u t e n a n d t ( M ü n c h e n ) R. C l a u s ( M ü n c h e n - W e i h e n s t e p h a n ) J . H a m m e r s t e i n ( B e r l i n ) K. D. H e p p ( M ü n c h e n ) P. W. J u n g b l u t ( W i l h e l m s h a v e n ) H. K a r g ( M ü n c h e n - W e i h e n s t e p h a n ) D. K n o r r ( M ü n c h e n ) R. L a n d g r a f ( M ü n c h e n ) H. M e h n e r t ( M ü n c h e n ) H. M i c k a n ( M ü n c h e n ) E. F. P fe i f f e r ( U l m ) C. R e n a t e P i c k a r d t ( M ü n c h e n ) D. S c h a m s ( M ü n c h e n - W e i h e n s t e p h a n ) R o s m a r i e V o g e l ( M ü n c h e n ) K. v o n W e r d e r ( M ü n c h e n ) W . W u t t k e ( G ö t t i n g e n ) R. Z i e g l e r ( U l m ) III CONTENTS A b s t r a c t n u m b e r s POSTER SESSIONS I, II, III a n d p a g e s T h y r o i d 1 - 26 T S H a n d T S I 2 7 - 47 A d r e n a l 4 8 - 56 A C T H a n d R e l a t e d P e p t i d e s 5 7 - 81 Test is 8 2 - 96 Ovary 9 7 - 1 1 4 P r e g n a n c y 1 1 5 - 1 2 0 P u b e r t y 1 2 1 - 1 2 8 G o n a d o t r o p h i ns 129 - 1 5 7 P r o l a c t i n 1 5 8 - 1 8 7 G r o w t h H o r m o n e 1 8 8 - 2 0 0 P i t u i t a r y T u m o r 201 - 2 0 5 O x y t o c i n / A D H 2 0 6 - 2 1 8 H y p o t h a l a m u s 2 1 9 - 2 3 6 P i n e a l / B r a i n H o r m o n e s 2 3 7 - 2 4 4 H o r m o n a l E f f ec t s o n C N S / B e h a v i o u r 2 4 5 - 2 5 3 C o m p a r a t i v e E n d o c r i n o l o g y / P h e r o m o n e s 2 5 4 - 2 6 0 R e c e p t o r s - S e x u a l S t e r o i d s 261 - 2 8 0 R e c e p t o r s - C o r t i c o s t e r o i d s 281 - 2 8 6 R e c e p t o r s - P r o t e o h o r m o n e s 2 8 7 - 3 0 1 M e t a b o l i s m / O b e s i t y 3 0 2 - 3 2 1 G a s t r o i n t e s t i n a l H o r m o n e s 3 2 2 - 3 2 5 P a r a t h y r i n / V i t a m i n D / C a l c i t o n i n 3 2 6 - 3 3 5 H y p e r t e n s i o n 3 3 6 - 3 5 3 SHORT COMMUNICATION SESSIONS 1-6 - ORAL PRESENTATION SC 1a G o n a d o t r o p h i n s 3 5 4 - 3 5 8 SC 1b O v a r y / P l a c e n t a 3 5 9 - 3 6 3 SC 2 a T h y r o i d 3 6 4 - 3 6 9 SC 2 b H y p o t h a l a m i c H o r m o n e s 3 7 0 - 3 7 3 SC 3 a A C T H a n d R e l a t e d P e p t i d e s 3 7 4 - 3 7 9 SC 3 b H y p e r t e n s i o n 3 8 0 - 3 8 3 SC 4 a S t e r o i d s : M e t a b o l i s m , E f fec t 3 8 4 - 3 8 9 SC 4 b H y p o g o n a d i s m 3 9 0 - 3 9 3 SC 5 a P r o l a c t i n / G r o w t h H o r m o n e 3 9 4 - 3 9 9 SC 5 b P a r a t h y r i n 4 0 0 - 4 0 3 SC 6 a M e t a b o l i s m / G a s t r o i n t e s t i n a l H o r m o n e s 4 0 4 - 4 0 8 SC 6 b A n t i d i u r e t i c H o r m o n e 4 0 9 - 4 1 3 IV SYMPOSIA 1-9 A b s t r a c t / p a g e s n u m b e r s S 1 N e u r o p e p t i d e s 4 1 4 - - 4 1 8 / 4 1 4 - -422 S 2 P h e r o m o n e s 4 1 9 - - 4 2 4 / 4 2 3 -- 4 3 3 S 3 T h e I n s u l i n R e c e p t o r 4 2 5 - - 4 2 9 / 4 3 4 --441 S 4 P r o g r e s s in T h y r o i d o l o g y 4 3 0 - -434 / 4 4 2 -- 4 4 9 S 5 " K i d n e y H o r m o n e s " in t h e R e g u l a t i o n o f V a s c u l a r a n d T u b u l a r F u n c t i o n s 4 3 5 - - 4 3 9 / 4 5 0 -- 4 5 6 S 6 S e x u a l D i m o r p h i s m 4 4 0 - - 4 4 4 / 4 5 7 -- 4 6 5 S 7 R e g u l a t i o n o f G o n a d o t r o p h i n S e c r e t i o n 4 4 5 - - 4 4 9 / 4 6 6 -- 4 7 2 S 8 H o r m o n e R e c e p t o r S y s t e m s 4 5 0 - - 4 5 4 / 4 7 3 -- 4 8 0 S 9 P r o g r e s s in t h e M a n a g e m e n t o f D i s o r d e r s o f C a l c i u m M e t a b o l i s m a n d B o n e D i seases 4 5 5 - - 4 5 9 / 4 8 1 - - 4 8 7 PLENARY LECTURES B.T. P I C K E R I N G : C e l l u l a r m e c h a n i s m o f h o r m o n e s y n t h e s i s , t r a n s p o r t a n d r e l e a s e 4 6 0 / 488 H. S T U D E R : P a t h o g e n e t i c m e c h a n i s m s r e s u l t i n g in e u t h y r o i d a n d h y p e r t h y r o i d , n o n - i m m u n o g e n i c g o i t e r s 4 6 1 / 489 W. J . I R V I N E : I m m u n o l o g y o f d i a b e t e s m e l l i t u s a n d o t h e r e n d o c r i n e d i s e a s e s 4 6 2 / 491 F O U R T H G E O F F R E Y H A R R I S M E M O R I A L L E C T U R E : B. F L E R K O : T h e h y p o p h y s i a l p o r t a l c i r c u l a t i o n t o - d a y 4 6 3 / 492 A W A R D S O F T H E G E R M A N S O C I E T Y FOR E N D O C R I N O L O G Y 4 6 4 - 4 6 8 / 4 9 4 - 5 1 3 V A c t a e n d o c r . (Kbh . ) S u p p l . 225 (1979) 9 MICROHETEROGENEITY OF THYROXINE-BINDING GLOBULIN (TBG) IN DIFFERENT METABOLIC STATES. + R.Gärtner, R.Henze, K.Horn, C.R.Pickardt and P.C.Scriba. M e d i z i n i s c h e K l i n i k Innenstadt der Universität München, FRG. The i n t e r p r e t a t i o n of microheterogeneity of TBG demonstrated i n i s o l a t e d TBG from pooled human serum i n a n a l y t i c a l i s o e l e c -t r i c f o c u s i n g (IEF) i s s t i l l c o n t r o v e r s i a l . Whereas Gershengorn et a l . (1977) assumed an i r r e v e r s i b l e t r a n s i t i o n of TBG near the i s o e l e c t r i c p o i n t we now could demonstrate t h a t microhetero-geneity of TBG i s caused by d i f f e r e n t N-acetylneuraminic a c i d contents. The purpose of t h i s study was to i n v e s t i g a t e the microheterogeneity of TBG i n n a t i v e human sera i n d i f f e r e n t metabolic s t a t e s and i n sera from p a t i e n t s w i t h TBG d e f i c i e n c y . Methods : IEF was performed on f l a t - b e d Polyacrylamide g e l s (PAG-plates), w i t h a continuous pH-gradient from pH 3.5 to 5.0 and pH 4.0 - 6.5 r e s p e c t i v e l y . The focussed TBG was i d e n t i f i e d by immunofixation using c e l l u l o s e - a c e t a t e s t r i p s , soaked w i t h monospecific TBG-antiserum. Immediately a f t e r IEF, s t r i p s were placed on the PAG-plates f o r an i n c u b a t i o n time of two minutes. The n o n - p r e c i p i t a t e d p r o t e i n s were removed by washing i n tap-water and the s t r i p s s t a i n e d w i t h Coomassie-Blue. R e s u l t s : In agreement w i t h the p a t t e r n of TBG i s o l a t e d from pooled serum three major TBG-bands were found at pH 4.55, pH 4.45, pH 4.35 and a minor band at pH 4.25 i n i n d i v i d u a l sera from normal a d u l t s . These t y p i c a l p a t t e r n s were a l s o demonstra-ted i n hypo- and h y p e r t h y r o i d i s m as w e l l as i n g e n e t i c TBG-d e f i c i e n c y . C h a r a c t e r i s t i c d e v i a t i o n s from t h i s microhetero-geneity c o u l d however be demonstrated i n pregnancy: du r i n g the continuous i n c r e a s e i n TBG-concentration a f u r t h e r band a t pH 4.15 appeared and the p r e c i p i t a t i o n l i n e a t pH 4.25 became more i n t e n s i v e , whereas the most a l k a l i n e band at pH 4.55 f a d e d -In c o n t r a s t , l i v e r d i s e a s e s w i t h e l e v a t e d TBG-concentrations are c h a r a c t e r i s e d by an i n t e n s i f i e d band at pH 4.55 and d i m i n u t i o n of the band at pH 4.25.In the sera of healthy mature newborns a comparable p a t t e r n to t h a t of normal a d u l t s was found. In c o n t r a s t , i n the sera of premature i n f a n t s four double bands were found i n the pH area t y p i c a l f o r normal a d u l t s This f o e t a l TBG p a t t e r n was normalized when the sera were re-examined 6 months l a t e r . C o nclusions : T y p i c a l microheterogeneity of TBG was found i n n a t i v e sera of normals which was not i n f l u e n c e d by t h y r o i d d i s -eases. However i n s t a t e s w i t h increased g l y c o p r o t e i n s y n t h e s i s as induced by oestrogens a more s i a l y l a t e d TBG, detected by an a d d i t i o n a l a c i d band c o u l d be demonstrated i n IEF. In c o n t r a s t , i n l i v e r d i s e a s e s w i t h diminished g l y c o p r o t e i n degradation an i n c r e a s e of d e s i a l y l a t e d TBG w i t h an i n t e n s i f i e d a l k a l i n e band was found. In g e n e t i c TBG d e f i c i e n c y microheterogeneity of TBG was comparable to t h a t of normals. Gershengorn M.C. et a l . : J.Biol.Chem.252 (1977) 8719-8723. + Supported by the Deutsche Forschungsgemeinschaft (Sonder-forschung sbere i c h 51) 9 

Microheterogeneity of thyroxine-binding globulin (TBG) in different metabolic states

Universität München: Elektronischen Publikationen

endocrino 
logica 
Supplementum 225 
Advance Abstracts 
of 
Papers 
XII Acta Endocrinologica Congress 
Munich 
June 26-30,1979 
PERIODICA • COPENHAGEN 1979 
E i g e n t u m d e r 
M ü n c h e n 
GENERAL CONTENTS 
C o n t e n t s in de ta i l IV 
T i m e - T a b l e VI 
P o s t e r S e s s i o n s 1 - 3 5 3 
S h o r t C o m m u n i c a t i o n S e s s i o n s - O r a l P r e s e n t a t i o n 3 5 4 - 4 1 3 
S y m p o s i a 4 1 4 - 4 8 7 
P l e n a r y L e c t u r e s 4 8 8 - 4 9 3 
A n w a r d s 4 9 4 - 5 1 3 
A u t h o r s ' I n d e x 5 1 5 - 5 2 7 
PROGRAMME ORGANIZING COMMITTEE 
C h a i r m a n : J . Z a n d e r ( M ü n c h e n ) 
S e c r e t a r y : P. C. S c r i b a ( M ü n c h e n ) 
F. B i d l i n g m a i e r ( M ü n c h e n ) 
M. B r e c k w o l d t ( F r e i b u r g ) 
O. B u t e n a n d t ( M ü n c h e n ) 
R. C l a u s ( M ü n c h e n - W e i h e n s t e p h a n ) 
J . H a m m e r s t e i n ( B e r l i n ) 
K. D. H e p p ( M ü n c h e n ) 
P. W. J u n g b l u t ( W i l h e l m s h a v e n ) 
H. K a r g ( M ü n c h e n - W e i h e n s t e p h a n ) 
D. K n o r r ( M ü n c h e n ) 
R. L a n d g r a f ( M ü n c h e n ) 
H. M e h n e r t ( M ü n c h e n ) 
H. M i c k a n ( M ü n c h e n ) 
E. F. P fe i f f e r ( U l m ) 
C. R e n a t e P i c k a r d t ( M ü n c h e n ) 
D. S c h a m s ( M ü n c h e n - W e i h e n s t e p h a n ) 
R o s m a r i e V o g e l ( M ü n c h e n ) 
K. v o n W e r d e r ( M ü n c h e n ) 
W . W u t t k e ( G ö t t i n g e n ) 
R. Z i e g l e r ( U l m ) 
III 
CONTENTS 
A b s t r a c t n u m b e r s 
POSTER SESSIONS I, II, III a n d p a g e s 
T h y r o i d 1 - 26 
T S H a n d T S I 2 7 - 47 
A d r e n a l 4 8 - 56 
A C T H a n d R e l a t e d P e p t i d e s 5 7 - 81 
Test is 8 2 - 96 
Ovary 9 7 - 1 1 4 
P r e g n a n c y 1 1 5 - 1 2 0 
P u b e r t y 1 2 1 - 1 2 8 
G o n a d o t r o p h i ns 129 - 1 5 7 
P r o l a c t i n 1 5 8 - 1 8 7 
G r o w t h H o r m o n e 1 8 8 - 2 0 0 
P i t u i t a r y T u m o r 201 - 2 0 5 
O x y t o c i n / A D H 2 0 6 - 2 1 8 
H y p o t h a l a m u s 2 1 9 - 2 3 6 
P i n e a l / B r a i n H o r m o n e s 2 3 7 - 2 4 4 
H o r m o n a l E f f ec t s o n C N S / B e h a v i o u r 2 4 5 - 2 5 3 
C o m p a r a t i v e E n d o c r i n o l o g y / P h e r o m o n e s 2 5 4 - 2 6 0 
R e c e p t o r s - S e x u a l S t e r o i d s 261 - 2 8 0 
R e c e p t o r s - C o r t i c o s t e r o i d s 281 - 2 8 6 
R e c e p t o r s - P r o t e o h o r m o n e s 2 8 7 - 3 0 1 
M e t a b o l i s m / O b e s i t y 3 0 2 - 3 2 1 
G a s t r o i n t e s t i n a l H o r m o n e s 3 2 2 - 3 2 5 
P a r a t h y r i n / V i t a m i n D / C a l c i t o n i n 3 2 6 - 3 3 5 
H y p e r t e n s i o n 3 3 6 - 3 5 3 
SHORT COMMUNICATION SESSIONS 1-6 
- ORAL PRESENTATION 
SC 1a G o n a d o t r o p h i n s 3 5 4 - 3 5 8 
SC 1b O v a r y / P l a c e n t a 3 5 9 - 3 6 3 
SC 2 a T h y r o i d 3 6 4 - 3 6 9 
SC 2 b H y p o t h a l a m i c H o r m o n e s 3 7 0 - 3 7 3 
SC 3 a A C T H a n d R e l a t e d P e p t i d e s 3 7 4 - 3 7 9 
SC 3 b H y p e r t e n s i o n 3 8 0 - 3 8 3 
SC 4 a S t e r o i d s : M e t a b o l i s m , E f fec t 3 8 4 - 3 8 9 
SC 4 b H y p o g o n a d i s m 3 9 0 - 3 9 3 
SC 5 a P r o l a c t i n / G r o w t h H o r m o n e 3 9 4 - 3 9 9 
SC 5 b P a r a t h y r i n 4 0 0 - 4 0 3 
SC 6 a M e t a b o l i s m / G a s t r o i n t e s t i n a l H o r m o n e s 4 0 4 - 4 0 8 
SC 6 b A n t i d i u r e t i c H o r m o n e 4 0 9 - 4 1 3 
IV 
SYMPOSIA 1-9 
A b s t r a c t / p a g e s 
n u m b e r s 
S 1 N e u r o p e p t i d e s 4 1 4 - - 4 1 8 / 4 1 4 - -422 
S 2 P h e r o m o n e s 4 1 9 - - 4 2 4 / 4 2 3 -- 4 3 3 
S 3 T h e I n s u l i n R e c e p t o r 4 2 5 - - 4 2 9 / 4 3 4 --441 
S 4 P r o g r e s s in T h y r o i d o l o g y 4 3 0 - -434 / 4 4 2 -- 4 4 9 
S 5 " K i d n e y H o r m o n e s " in t h e R e g u l a t i o n 
o f V a s c u l a r a n d T u b u l a r F u n c t i o n s 4 3 5 - - 4 3 9 / 4 5 0 -- 4 5 6 
S 6 S e x u a l D i m o r p h i s m 4 4 0 - - 4 4 4 / 4 5 7 -- 4 6 5 
S 7 R e g u l a t i o n o f G o n a d o t r o p h i n S e c r e t i o n 4 4 5 - - 4 4 9 / 4 6 6 -- 4 7 2 
S 8 H o r m o n e R e c e p t o r S y s t e m s 4 5 0 - - 4 5 4 / 4 7 3 -- 4 8 0 
S 9 P r o g r e s s in t h e M a n a g e m e n t o f D i s o r d e r s 
o f C a l c i u m M e t a b o l i s m a n d B o n e D i seases 4 5 5 - - 4 5 9 / 4 8 1 - - 4 8 7 
PLENARY LECTURES 
B.T. P I C K E R I N G : C e l l u l a r m e c h a n i s m o f h o r m o n e 
s y n t h e s i s , t r a n s p o r t a n d r e l e a s e 4 6 0 / 488 
H. S T U D E R : P a t h o g e n e t i c m e c h a n i s m s r e s u l t i n g 
in e u t h y r o i d a n d h y p e r t h y r o i d , n o n - i m m u n o g e n i c 
g o i t e r s 4 6 1 / 489 
W. J . I R V I N E : I m m u n o l o g y o f d i a b e t e s m e l l i t u s 
a n d o t h e r e n d o c r i n e d i s e a s e s 4 6 2 / 491 
F O U R T H G E O F F R E Y H A R R I S M E M O R I A L L E C T U R E : 
B. F L E R K O : T h e h y p o p h y s i a l p o r t a l c i r c u l a t i o n t o - d a y 4 6 3 / 492 
A W A R D S O F T H E G E R M A N S O C I E T Y 
FOR E N D O C R I N O L O G Y 4 6 4 - 4 6 8 / 4 9 4 - 5 1 3 
V 
A c t a e n d o c r . (Kbh . ) S u p p l . 225 (1979) 
9 MICROHETEROGENEITY OF THYROXINE-BINDING GLOBULIN (TBG) 
IN DIFFERENT METABOLIC STATES. + R.Gärtner, R.Henze, 
K.Horn, C.R.Pickardt and P.C.Scriba. M e d i z i n i s c h e K l i n i k 
Innenstadt der Universität München, FRG. 
The i n t e r p r e t a t i o n of microheterogeneity of TBG demonstrated 
i n i s o l a t e d TBG from pooled human serum i n a n a l y t i c a l i s o e l e c -
t r i c f o c u s i n g (IEF) i s s t i l l c o n t r o v e r s i a l . Whereas Gershengorn 
et a l . (1977) assumed an i r r e v e r s i b l e t r a n s i t i o n of TBG near 
the i s o e l e c t r i c p o i n t we now could demonstrate t h a t microhetero-
geneity of TBG i s caused by d i f f e r e n t N-acetylneuraminic a c i d 
contents. The purpose of t h i s study was to i n v e s t i g a t e the 
microheterogeneity of TBG i n n a t i v e human sera i n d i f f e r e n t 
metabolic s t a t e s and i n sera from p a t i e n t s w i t h TBG d e f i c i e n c y . 
Methods : IEF was performed on f l a t - b e d Polyacrylamide g e l s 
(PAG-plates), w i t h a continuous pH-gradient from pH 3.5 to 5.0 
and pH 4.0 - 6.5 r e s p e c t i v e l y . The focussed TBG was i d e n t i f i e d 
by immunofixation using c e l l u l o s e - a c e t a t e s t r i p s , soaked w i t h 
monospecific TBG-antiserum. Immediately a f t e r IEF, s t r i p s were 
placed on the PAG-plates f o r an i n c u b a t i o n time of two minutes. 
The n o n - p r e c i p i t a t e d p r o t e i n s were removed by washing i n tap-
water and the s t r i p s s t a i n e d w i t h Coomassie-Blue. 
R e s u l t s : In agreement w i t h the p a t t e r n of TBG i s o l a t e d from 
pooled serum three major TBG-bands were found at pH 4.55, 
pH 4.45, pH 4.35 and a minor band at pH 4.25 i n i n d i v i d u a l sera 
from normal a d u l t s . These t y p i c a l p a t t e r n s were a l s o demonstra-
ted i n hypo- and h y p e r t h y r o i d i s m as w e l l as i n g e n e t i c TBG-
d e f i c i e n c y . C h a r a c t e r i s t i c d e v i a t i o n s from t h i s microhetero-
geneity c o u l d however be demonstrated i n pregnancy: du r i n g the 
continuous i n c r e a s e i n TBG-concentration a f u r t h e r band a t 
pH 4.15 appeared and the p r e c i p i t a t i o n l i n e a t pH 4.25 became 
more i n t e n s i v e , whereas the most a l k a l i n e band at pH 4.55 f a d e d -
In c o n t r a s t , l i v e r d i s e a s e s w i t h e l e v a t e d TBG-concentrations 
are c h a r a c t e r i s e d by an i n t e n s i f i e d band at pH 4.55 and 
d i m i n u t i o n of the band at pH 4.25.In the sera of healthy mature 
newborns a comparable p a t t e r n to t h a t of normal a d u l t s was 
found. In c o n t r a s t , i n the sera of premature i n f a n t s four 
double bands were found i n the pH area t y p i c a l f o r normal a d u l t s 
This f o e t a l TBG p a t t e r n was normalized when the sera were 
re-examined 6 months l a t e r . 
C o nclusions : T y p i c a l microheterogeneity of TBG was found i n 
n a t i v e sera of normals which was not i n f l u e n c e d by t h y r o i d d i s -
eases. However i n s t a t e s w i t h increased g l y c o p r o t e i n s y n t h e s i s 
as induced by oestrogens a more s i a l y l a t e d TBG, detected by an 
a d d i t i o n a l a c i d band c o u l d be demonstrated i n IEF. In c o n t r a s t , 
i n l i v e r d i s e a s e s w i t h diminished g l y c o p r o t e i n degradation an 
i n c r e a s e of d e s i a l y l a t e d TBG w i t h an i n t e n s i f i e d a l k a l i n e band 
was found. In g e n e t i c TBG d e f i c i e n c y microheterogeneity of TBG 
was comparable to t h a t of normals. 
Gershengorn M.C. et a l . : J.Biol.Chem.252 (1977) 8719-8723. 
+ Supported by the Deutsche Forschungsgemeinschaft (Sonder-
forschung sbere i c h 51) 
9 


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Microheterogeneity of thyroxine-binding globulin (TBG) in different metabolic states

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