Alt, J.

Gerzer, R.

Klingler, W.

Lawrenz, R.

Müller-Esch, G.

Scriba, Peter Christian

English

Universität München: Elektronischen Publikationen

Interaction between atrial natriuretic peptide (a-hANP) and hypothalamic-pituitary function in normal man

Open Access LMU

American Journalof Hypotension JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION T H O M A S D. GILES New Orleans, Louisiana E D I T O R - I N - C H I E F J O H N H . L A R A G H New York, New York E D I T O R S M I C H A E L A . WEBER I r v i n e , C a l i f o r n i a N O R M A N M . K A P L A N D a l l a s , Texas D E P U T Y E D I T O R S L A W R E N C E R. K R A K O F F L A W R E N C E M . RESNICK New York, New York New York, New York J O H N BAXTER San Francisco, C a l i f o r n i a G E R A L D R D I B O N A I o w a C i t y , I o w a C O N S U L T I N G E D I T O R S BARRY M . B R E N N E R Boston, Massachusetts J E A N E . S E A L E Y New York, New York J A Y N . C O H N Minneapolis, Minnesota E D H . S O N N E N B L I C K New York, New York M . H . A L D E R M A N N e i v York, N e w York S . A . A T L A S N e w York, N e w York E . G . B I G L I E R I San F r a n c i s c o , C a l i f o r n i a D . M . B L A U F O X N e w Y o r k , N e w York V . M . B U C K A L E W , J R . W i n s t o n S a l e m , N o r t h C a r o l i n a E R . B U H L E R Basle, S w i t z e r l a n d H.R. BRUNNER L a u s a n n e , S w i t z e r l a n d P J . C A N N O N N e w Y o r k , N e w York R . M . C A R E Y C h a r l o t t e s v i l l e , V i r g i n i a J. D E C H A M P L A I N M o n t r e a l , C a n a d a R J . C O D Y N e w Y o r k , N e w York A . J . D E B O L D O t t a w a , C a n a d a E D I T O R I A L B O A R D R . B . D E V E R E U X N e w York, N e w York M . E P S T E I N M i a m i , F l o r i d a W . F L A M E N B A U M N e w York, N e i v York W. FRISHMAN N e i v York, N e w York M. GOLDBERG P h i l a d e l p h i a , P e n n s y l v a n i a P. H A M E T M o n t r e a l , C a n a d a M . H O R A N Bethesda, M a r y l a n d T. INAGAMI N a s h v i l l e , Tennessee E. LIEBERMAN Los A n g e l e s , C a l i f o r n i a M.H. MAXWELL Los A n g e l e s , C a l i f o r n i a D.A. McCARRON P o r t l a n d , O r e g o n M.I. NEW N e w York, N e w York M . H . P E R R Y S t . L o u i s , M i s s o u r i C . V . S. R A M D a l l a s , Texas D . J . R E I S N e w York, N e w York D . S A V A G E Bethesda, M a r y l a n d J.A. SCHOENBERGER C h i c a g o , I l l i n o i s A. SINAIKO M i n n e a p o l i s , M i n n e s o t a J.H. STEIN San A n t o n i o , Texas D . H . P . S T R E E T E N S y r a c u s e , N e w York L. TOBIAN M i n n e a p o l i s , M i n n e s o t a P . M . V A N H O U T T E Rochester, M i n n e s o t a B . R . W A L K E R P h i l a d e l p h i a , P e n n s y l v a n i a M A N A G I N G E D I T O R JOANBANES American Society of Hypertension, 515 Madison Avenue, Suite 2100, New York, NY10022 (212) 644-0650 VOLUME 1, NUMBER 3, PART 2, JULY 1988 American Journal of Hypertension JOURNAL OF THE A M E R I C A N SOCIETY OF HYPERTENSION C O N T E N T S S P E C I A L A W A R D S 1 A A S H P R O G R A M S A S H A B S T R A C T S 6 A Cardiology 17A Pharmacology and Therapeutics 40A Endocrinology/Central Nervous System 54A Epidemiology 61A Electrolyte/Membrane Transport 68A Nephrology 80A Noninvasive Techniques 87A B A A P P R O G R A M B A A P A B S T R A C T S 89A ANP: Peptide Synthesis, Storage, Release, and Metabolism 93A Cardiovascular and Neurological Actions of ANP 102A ANP and Renal Function 109A ANP and the Endocrine System 121A ANP Receptors and Second Messengers AMERICAN JOURNAL OF HYPERTENSION (ISSN 0895-7061) is issued in one volume in four issues plus two special issues by Elsevier Science Publishing Co, Ine, 52 Vanderbilt Avenue, New York, NY10017. 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C O N T E N T S c o n t i n u e d 128A ANP in Cardiovascular Disorders 135A ANP in Renal and Hepatic Disorders 140A ANP in Hypertension A U T H O R INDEXES 144A Third Annual Meeting of the American Society of Hypertension 149A Third Annual World Congress on Biologically Active Atrial Peptides GENERAL INFORMATION AMERICAN JOURNAL OF HYPERTENSION (ISSN 0895-7061) (in-corporating JOURNAL OF CLINICAL HYPERTENSION) is issued in one volume in four issues plus two special issues by Elsevier Science Publishing Co., Inc., 52 Vanderbilt Avenue, New York, NY 10017. Subscription prices per year: Institution, $98.00; individual, $49.00; interns and residents, $30.00. Outside of the U.S. and possessions, please add $16.00 for surface delivery. Second class postage pending at New York, NY, and at additional mailing offices. Claims for missing issues can be honored only up to 3 months for domestic addresses and 6 months for foreign addresses. 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This consent is given on the condition that the copier pay through the Center the per copy fee stated in the code on the first page of each article for copying beyond that permitted by the U.S. Copyright Law. If no code appears on an article, the author has not given broad consent to copy, and permission to copy must be obtained directly from the author. This consent does not extend to other kinds of copy-ing, such as for general distribution, resale, advertising, and promo-tional purposes, or for creating new collective works. © 1988 by the American Journal of Hypertension, Inc. The appearance of advertising in the AMERICAN JOURNAL OF HY-PERTENSION does not constitute a guarantee or endorsement of the quality or value of such product or of the Claims made for it by its manufacturer. The fact that a product, Service, or Company is adver-tised in this publication shall not be referred to by the manufacturer in collateral advertising. No responsibility is assumed by the Publisher for any injury and/or damage to persons or property as a matter of products liability, negli-gence or otherwise, or from any use or Operation of any methods, products, instructions or ideas contained in the material herein. No suggested test or procedure should be carried out unless, in the readers' judgment, its risk is justified. Because of rapid advances in the medical sciences, we recommend that the independent verification of diagnoses and drug dosages should be made. Discussions, views and recommendations as to medical procedures, choice of drugs and drug dosages are the responsibility of the authors. 112A BIOLOGICALLY A C T I V E ATRIAL PEPTIDES A J H - J U L Y 1 9 8 8 - V O L . 1 , N O . 3, P A R T 2 Interaction between atrial natriuretic peptide [5044 ( a - h A N P ) and hypothalamic-pituitary function i n normal man G Müller-Esch, W Klingler, J Alt, R Gerzer, R Lawrenz, and P C Scriba. D e p t s . M e d i a n e a n d B i o c h e m . E n d o c r i n o l o g y , M e d i c a l U n i v . , Lübeck, a n d D e p t . M e d i c i n e , U n i v . München, F R G The relation between A N P and the anterior pituitary is poorly understood. We therefore studied 1. the influence of releasing hormone-induced pituitary Stimulation on endoge-nous A N P secretion and 2. the effects of exogenous a - h A N P -administration on releasing hormone-induced pituitary secre-tion. 10 healthy volunteers (5 female, 5 male) were studied twice by means of a combined pituitary function test (Combibiss® Bissendorf, FRG). After an overnight fast and bed rest, 200 jug T R H , 100 ßg h C R F , 50 \i% G R H and 100 pig G n R H were either injected at once (protocol 1) or after an a - h A N P bolus of 100 jug followed by an infusion of 0.1 /zg/kg/min over 30 min (protocol 2). Hormone responses for A C T H , cortisol, G H , L H , F S H and prolactin did not differ for both protocols. a - h A N P dimin-ished theTRH-induced TSH-increase (maximum 6.4 ± 3 . 0 vs. 11.5 ± 5.4 / / U / m l (x ± SD, p < 0.001). Serum levels for A N P and c G M P remained constant during protocol 1, whereas c G M P increased from 3.96 ± 1,34 to 44.53 ± 10,52 nmol/1 in protocol 2. C o n c l u s i o n s : 1. In normal man, Stimulation of the anterior pituitary induced by releasing hormone administration does not influence endogenous ANP-secretion. 2. a - h A N P , when given b e f o r e releasing hormone injection, attenuates T R H - i n -duced T S H secretion; all other pituitary hormone responses remain unaltered. 3. c G M P may serve as a marker for a -hANP-actions. 

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Interaction between atrial natriuretic peptide (a-hANP) and hypothalamic-pituitary function in normal man

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