Ball, P.

Lühe, C. von der

Müller-Esch, G.

Schlüter, K. J.

Scriba, Peter Christian

English

Open Access LMU

European Journal of C l in ica l Investigation The Journal of the European Society for Clinical Investigation 4 Q'i^rt,-E d i t o r s - i n - C h i e f K. Winkler, 0 . B. Paulson E d i t o r i a l B o a r d C. E. Anderson, M. Arborelius, J r , G. Bendixen, N. Juel Christensen, M. Dalmark, O. Faergeman, J . Giese, S . Jarnum, N. Keiding, L. Korsgaard Christensen, E. Krag, N. A. Lassen, J . Ladefoged, J . Rask Madsen, P. McNair, H. Meinertz, N. Nissen, J . Rehfeld, 0 . Siggaard-Andersen, N. A. Thorn, I. Transbol, N. Tygstrup, J . Wahren, J . 0 . Wieth V o l u m e 15 , 1 9 8 5 Published for the European Society for Clinical Investigation by Blackwell Scient i f ic Publications, Oxford London Edinburgh Boston Palo Alto Melbourne Published by Blackwell Scientific Publications Ltd, Osney Mead , Oxford O X 2 OEL, U.K. © 1985 Black well Scientific Publications Ltd. Author iza t ion of pho tocopy items for internal or personal use, or the internal or personal use of specific clients, is granted by Blackwell Scientific Publications Ltd for libraries and other users registered with the Copyright Clearance Center (CCC) Transact ional Repor t ing Service, provided that the base fee of $02-00 per copy is paid directly to C C C , 27 Congress Street, Salem, M A 01970, U.S.A. Special requests should be addressed to the Editor . 0014-2972/85 $02-00. The use of registered names, t rade marks , etc., in this publ icat ion does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulation and therefore free for general use. Printed in Great Britain at the Alden Press, Oxford. Universitäts-Bibliothek München C o n t e n t s o f V o l u m e 15 Number 2, April 1985 Number 1, February 1985 Stimulation of peritoneal synthesis of vasoactive prostaglandins during peritonitis in patients on continuous ambulatory peritoneal dialysis H. B. Steinhauer, B. Günter and P. Schollmeyer 1 Coexistance of hypocalciuric hypercalcaemia and interstitial lung disease in a family: a cross-sectional study Johan Auwerx, Maur i t s Demedts , Roger Bouillon and Johan Desmet 6 Differences in basal and stimulated cyclic A M P content in calvaria bones from normal mice and mice with an impaired lysosomal function (beige mice) M. Ransjo, B. B. Fredholm, U. Lerner and G. T. Gustafson 15 Effect of dazoxiben, a thromboxane synthetase inhibitor on skin-blood flow following cold challenge in patients with Raynaud's phenomenon H. Tindall , J. E. Tooke , V. C. Menys, M . F . R. Mar t in and J. A. Davies 20 Defective renal water excretion in nephrotic syndrome: the relationship between renal water excretion and kidney function, arginine vasopressin, angiotensin II and aldosterone in plasma before and after oral water loading E. B. Pedersen, H. Danielsen, M. Madsen and T. Jensen 24 Adrenergic regulation of lypolysis in abdominal adipocytes of obese subjects during caloric restriction: reversal of catecholamine action caused by relief of endogenous inhibition H . Kather , E. Wieland, B. Fischer, A. Wirth and G. Schlierf 30 Effect of renal function on renal responsiveness to parathyroid hormone in primary hyperthyroidism and chronic renal failure I. G. Lewin, G. N . Hendy, S. E. Papapoulos , S. Tomlinson and J. L. H. O 'R io rdan 38 Plasma oxalate concentration and oxalate distribution volume in patients with normal and decreased renal function J. A. C. Prenen, E. J. D o r h o u t Mees and P. Boer 45 Instructions to authors i Editorial: Models and mechanisms on very low density lipoprotein metabolism C. J. Packard and J. Shepherd 51 Effects of dopamine and dobutamine on the distribution of pulmonary blood flow during lobular ventilation hypoxia and lobular collapse in dogs P. A. McFar lane , A. J. Mor t imer , W. A. Ryder , R. G. Madgwick, J.-P. Gardaz , B. J Harr ison and M. K. Sykes 53 Granulocyte migration in ulcerative colitis S. H. Saverymuttu, V. S. Chadwick and H. J. F . Hodgson 60 Immunofluorescence detection of liver cell membrane autoantibodies using PLC/PRF/1 cells R. W. de Koning, M. Daemen, B. Schutte, H. G M. Geertzen, G. H. Blijham and F. T. Bosman 64 Variation in serum Type III procollagen peptide with age in healthy subjects and its comparative value in the assessment of disease activity in children and adults with chronic active hepatitis P. Trivedi, P. Cheeseman, B. Po r tmann , J. Hegar ty and A. P. Mowa t 69 Abnormality of adenylate cyclase regulation in human platelet membranes in renal insufficiency B. Jacobsson, L. Ransnäs, G. Nyberg, C. H. Bergh, Y. Magnusson and Ä. Hjalmarson 75 Abnormalities of in vitro responses to polyclonal activation of peripheral blood lymphocytes in patients with active sarcoidosis J.-L. Pasquali , D . Godin , A. Urlacher, A. Pelletier, G. Pauli and D . Storck 82 Correlation of disease activity in systemic vasculitis with serum C-reactive protein measurement. A prospective study of thirty-eight patients C. R. K. Hind, C. G. Winearls and M. B. Pepys 89 Vitamins D3 uptake by the isolated perfused rat liver from lipoprotein fractions is separate from cholesterol and trigyceride uptake E. Ziv, H . Bar-On and J. Silver 95 Plasma apolipoprotein B metabolism in familial type III dysbetalipo-proteinaemia P. R. Turner , C. Cortese, R. Woo t ton , C. Marenah , N . E. Miller and B. Lewis 100 iii iv C O N T E N T S Number 3, June 1985 Insulin in vivo increases the in vitro fall of plasma potassium concentration in human venous blood N . A. Kalsheker and C. N . Hales 113 Concentrative transport of purine nucleosides in brush border vesicles of the rat kidney M. le Hir and U. C. Dubach 121 Effect of in vitro non-enzymatic glycosylation of human skin collagen on susceptibility to collagenase digestion T. J. Lyons and L. Kennedy 128 Type IV collagen and laminin-related antigens in human serum in alcoholic liver disease Onni Niemelä, Leila Risteli, Eero A. Sotaniemi and Juha Risteli 132 Bactericidal activity of ascitic fluid in patients with nephrotic syndrome H. E. Akalin, K. A. Fisher, Yahya Laleli and Sali Caglar 138 Active and acid-activable inactive renin during inhibition by indomethacin of prostaglandin synthesis in sodium-replete man P. Lijnen, J. Staessen, R. Fagard , D. Groeseneken, J. R. M ' B u y a m b a - K a b a n g u , R. Grauwels and A. Amery 141 Drug influences on rat hepatic macrophage enzyme production and release in vitro A. R. Tanner , A. H. Keyhani and R. Wright 146 Is the renal kallikrein system relevant to sodium sensitivity in patients with essential hypertension M. I. Koolen, M. R. Daha and P. van Brummelen 151 Reduced tubular reabsorption of phosphate during post-operative glucose infusions in humans Allan Rasmussen and Laws Jespersen 157 Number 4, August 1985 Fibrinolytic study in plasma and ascitic fluid of cirrhotic patients before and after ascites concentration; reinfusion technique G. M . Patrassi , S. Martineiii , G. C. Sturniolo, M . G. Cappel la to , M . Vicariotto and A. Gi ro lami 161 Effect of sympathetic stimulation and intrarenal alpha-blockade on the secretion of renin by the human kidney P. W. de Leeuw, R. de Bos, P. N . van Es and W. H. Birkenhäger 166 Bioavailability, gastrointestinal transit, solubilization and faecal excretion of ursodeoxycholic acid in man M. Parquet , E. H . Me tman , A. Ra izman , J. C. R a m b a u d , N . Berthaux and R. Infante 171 Relationship of brain glutamine and brain neutral amino acid concentration after portacaval anastomosis in rats B. Jeppsson, J. H o w a r d James , L. L. Edwards and J. E. Fischer 179 Effect of heparin and aspirin on platelet and clotting activation during leukapheresis F. Fabr is , A. Casona to , M. L. Rand i , M. Belloni, V. Quaino , G. Onga ro and A. Girolami 188 Duodenal gamma-glutamyltransferase activity in human biopsies: effect of chronic ethanol consumption and duodenal morphology H. K. Seitz, D . Velasquez, R. Waldher r et al. 192 Metabolic response to different forms of physical exercise in type 1 diabetics and the duration of the glucose lowering effect A. Hübinger, I. R idderskamp, E. Lehmann and F . Arnold Gries 197 Age related changes of platelet prostacyclin receptors in humans P. A. Modest i , A. Fort ini , R. Abba te and G. F. Gensini 204 Evidence for a Na-K-ATPase-inhibitor in erythrocytes of patients with essential hypertension U. Walter and S. Müller 209 Lipolytic and anticoagulant activities of a low molecular weight fragment of heparin E. Persson, J. Nordenström, P. Nilsson-Ehle and L. Hagenfeldt 215 Role of gastrointestinal tract liver in acetate metabolism in rat and man D . B. J. He r rmann , R. Herz and J. Fröhlich 221 Cytotoxicity of lectins on rat intestinal mucosa enhanced by neuraminidase H. Lorenz-Meyer , H. Roth , P. Elsässer and U. H a h n 227 C O N T E N T S Number 5, October 1985 Editorial: Immunogenetics of disease, mechanisms and clinical aspects M. Thomsen 235 Editorial: Cytosolic free calcium, a key second messenger in cellular activation P. D. Lew 238 Editorial: Activation of phagocytes N. Borregaard 240 Serum /^-microglobulin at remission and relapse in patients with multiple myeloma G. Brenning, L. Wibell and R. Bergström 242 Regional and systemic effects of short-term intense muscular work on plasma concentration and content of total and ionized calcium S. Ljunghall , H. Joborn , L. Lundin , J. Rastad, L. Wide and G. Äkerström 248 Pharmacokinetic and pharmacodynamic interaction between furosemide and metolazone in man C. Marone , F. Muggli , W. Lahn and F. J. Frey 253 B complex vitamins activate rat guanylate cvclase and increase cyclic G M P levels D. L. Vesely 258 Relationship between turnover rate and oxidation rate of alanine in the post-absorptive state and during parenteral nutrition before and after surgery H. P. Sauerwein, R. P. J. Michels and V. Cejka 263 Glucocorticoid hormone binding to human adipose tissue M. Rebuffe-Scrive, K. Lundholm and P. Björntorp 267 Naloxone inhibits sulpiride-induced hyperprolactinaemia in man G. P. Bernini, R. Pedrinelli, A. Salvetti, F. Franchi and M. Luisi 272 Changes in quantitative measures of hepatic function after 90% hepatectomy in rats H. E. Poulsen, J. G a u b and J. Iversen 285 Antibodies to human T-cell lymphotropic virus type III in promiscuous healthy homosexual men. Relation to immunological and clinical findings J. Gerstoft, B. Orskov Lindhardt , C. S. Petersen, S. Kroon , S. Ul lman, S. Moller, J. Ole Nielsen and E. Dickmeiss 290 Number 6, December 1985 Editorial: Recent trends in renal immunopathology P. Drue t and P. Verroust 297 Editorial: Brain and behaviour T. L. Bolwig 300 Thigh muscle mass and function in patients treated with glucocorticoids F. F . Horber , J. T. Scheidegger, B. E. Grünig and F . J. Frey 302 Fibrinolytic shut-down after surgery: impairment of the balance between tissue-type plasminogen activator and its specific inhibitor A. d^Angelo, C. Kluft, J. H. Verheijen, D. C. Rejken, E. Mozzi and P. M. Mannucci 308 Heparin-induced platelet aggregation in anorexia nervosa and in severe peripheral vascular disease D. P. Mikhailidis, M. A. Barradas , J. Y. Jeremy, L. Gracey, A. Wakel ing and P. D a n d o n a 313 Stimulatory cholinergic effect on the release of antiaggregatory activity into the circulation of cat and man its modification by /^-adrenergic antagonists J. Swies, M . Radomski , A. Dembinska-Kiec , R. Korbu t , R. J. Gryglewski, R. Brandt and J. N o w a k 320 Blood to interstitial fluid volume ratio in chronic hypokalaemic states P. Boer, H. A. K o o m a n s , R. J. Hene, G. G. Geyskes, B. A. M. Van Shaik, J. C. Roos and E. J. D o r h o u t Mees 276 Variant of acute intermittent porphyria with normal erythrocyte uroporphyrinogen-I-synthase activity P. Mustajoki and R. Tenhunen 281 Production of leukotrienes and prostaglandins by human ascites cells R. J. Th. Ouwendijk, F . J. Zijlstra, J. H . P. Wilson, J. E. Vincent and T. L. Bonta 327 Neutral steroid metabolites in patients with uraemia and after renal transplantation: a quantitative and qualitative study in body fluids Helga Ludwig-Köhn, J. V. Henning, Astrid Sziedat, P. Klug, H. Alexander and F. Scheler 332 C O N T E N T S Evidence that epinephrine acts preferentially as an antilipolytic agent in abdominal human subcutaneous fat cells: assessment by analysis of beta and alpha2 adrenoceptors properties Michel Berlan and Max Lafontan Renal water and sodium handling in compensated liver cirrhosis: mechanism of the impaired natriuresis after saline loading L. Caregaro , S. Lauro , P. Angeli, C. Merkel and A. Ga t t a 341 Direct determination of leucine metabolism and protein breakdown in humans using L-( ,3C, ,5N]-leucine and the forearm model K. N . Cheng, F . Dworzak , G. C. Ford, and D. Hall iday 349 Effect of Captopril infusion on systemic and renal haemodynamics in conscious hypertensive rats with chronic, progressive aortic ligation Luis M. Gonzalez-Perez, Vicente Mart in-Paredero, Santos Casado and Jose M. Lopez-Novoa 355 360 Discrepancies in the catabolic pathways of human and rat high-density lipoprotein apolipoprotein A-T in the rat Ferdinand M. van ' t Hooft and Arie van Tol 395 Platelet alpha2 adrenoceptors in Parkinson's disease: decreased number in untreated patients and recovery after treatment Alain Villeneuve, Michel Berlan, Max Lafontan, Claudine Caranobe , Bernard Boneu, Andre Rascol and Jean-Louis M o n t a s t r u c 403 Reduced strength of skin in osteogenesis imperfecta H a n s Oxlund, Ulrik Pedersen, Carl Danielsen, Inger Oxlund and Ole Elbroond 408 Effect of incremental doses of aspirin on bleeding time, platelet aggregation and thromboxane production in patients with cerebrovascular disease A Hasager Boss, G. Boysen and J. Steen Olseen 412 Total and unbound Cortisol-, progesterone-, oestrone- and transcortin-binding activities in sera from patients with myocardial infarction: evidence for differential responses of good and bad prognostic cases Hassen Zouaghi , Lia Savu, Claude Guerot , Raymond G r y m a n , Aline Coulon and Emmanuel A. Nunez 365 Sulphur amino-acid degradation in subjects with hereditary glutathione synthetase deficiency (5-oxoprolinuria) Johannes Märtensson, Bertil Kägedal and Agne Larsson 371 On the mechanism of renin release during experimental myocardial ischaemia Georg Ertl , Mal te Meesmann and Kur t Kochsiek 375 Phosphocreatine content and intracellular pH of calf muscle measured by phosphorus NMR spectroscropy in occlusive arterial disease of the legs U. Keller, R. Oberhänsli, P. Huber , L. K. Widmer , W. P. Aue, R. I. Hassink, S. Müller and J. Sellig 382 Rheological and transport properties of airway secretions in cystic fibrosis—relationships with the degree of infection and severity of the disease E. Puchelle, J. Jacquot , G. Beck, J. M. Z a h m and C. Galaber t 389 Experimental studies on the adult respiratory distress syndrome: effects of induced DIC; granulocytes and elastase in mini pigs T. Stokke, H. Burchardi , I. Hensel and W. H. Horl 415 Levels of ventricular myosin fragments in human sera after myocardial infarction, determined with monoclonal antibodies to myosin heavy chains J. O. C. Leger, P. Bouvagnet , B. Pau, R. Roncucci and J. J. Leger 422 Disposition of di- and mono-(2-ethylhexyl) phthalate in newborn infants subjected to exchange transfusions P. Sjöberg, U. Bondesson, G. Sedin and J. Gustafsson 430 Editorial Acknowledgment 437 Author Index Key Word Index 441 HORMONAL (»UNTERREGULATION DURING STANDARDIZED HYPOGLYCEMIA TEST COMPARING BIOSYNTHETIC HUMAN PROINSULIN AND HUMAN INSULIN G. Müller-Esch, C. von der Lühe, P. Ball, K.J. Schlüter, P.C. Scriba Dept. of Medicine and Inst, for Biochem. Endocrinol., Medizinische Hochschule Lübeck, West Germany* The aim of this study was to compare the counterregulatory effects following administration of biosynthetic human proinsulin (BHP1) and human insulin (BHD during hypoglycemia stan-dardized by means of a glucose controlled insulin infusion system (GCIIS). Material and methods^: Eight healthy volunteers were studied after an overnight fast using the GCIIS (Biostator ) on static control as previously described (1). Results: A total of 0.148-0.010 U/kg of BHPI had to be given by the GCIIS in order to obtain minimal blood glucose (BG) of 26-2 mg/dl (x-SEM) at 43-2 min. In contrast 0.083-0.004 U/kg of BHI were sufficient to produce a minimal BG of 21-1 mg/dl (n.s.) at 35-1 min(p<0.005). Moreover, BHPI administration resulted in prolonged hypoglycemia and delayed BG recovery as compared to BHI (BG at 120 min: 46-3 for BHPI vs. 78-3 mg/dl for BHI). On a molar basis the BG lowering effect of BHPI was about 13$ that of BHI. No severe side effects were ob-served and there was no need for dextrose administration, but clinical symptoms of hypogly-cemia were more pronounced after BHPI infusion. Compared to BHI, BHPI produced higher peak levels for Cortisol (252-16 vs. 168-10 ng/ml), a more pronounced secretion of GH and prolac-tin as well as a stronger decline of serum potassium (3.20-0.06 vs. 3.58-0.08 mmol/1). In addition, urinary epinephrine excretion following hypoglycemia after BHPI exceeded that after BHI (10.3-4.8 vs. 3.0-0.5 pg/120 min). Conclusion: These preliminary results suggest that the observed more distinct glucose coun-terregulation is due to prolonged hypoglycemia rather than to any specific BHPI action on the hypothalamic-pituitary axis. Whether this "depot effect" may be beneficial in the treat-ment of diabetes mellitus remains to be established. References: 1. Müller-Esch, G., 8all, P., Heidbüchel, K., Wood, W.G., Scriba, P.C.: Acta Endocrinol. (Copenh.) 106 (1984); 350-356 A 15 

Hormonal Counterregulation during standardized Hypoglycemia Test comparing Biosynthetic Human Proinsulin and Human Insulin

Universität München: Elektronischen Publikationen

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Hormonal Counterregulation during standardized Hypoglycemia Test comparing Biosynthetic Human Proinsulin and Human Insulin

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