Das, Rathindra C.

Neupert, Walter

Nicholson, Donald W.

Robbins, P. W.

English

Open Access LMU ( Ludwig-Maximilians-Univ. München)

17. Synthesis and Assembly of Mitochondrial Proteins 741 Molecular cloning and amino acid sequence of the precursor form of bovine adrenodoxin: Evidence for a previously unidentified COOH-terminal peptide.

A 70-kd protein of the yeast mitochondrial outer membrane is targeted and anchored via its extreme amino terminus.

A cDNA clone for the precursor of rat mitochondrial Ornithine transcarbamylase: Comparison of rat and human leader sequences and conservation of catalytic sites.

A chemically synthesized pre-sequence of an imported mitochondrial protein can form an amphiphilic helix and perturb natural and artifical phospholipid bilayers.

A cytosolic protein contains a cryptic mitochondrial targeting signal.

A highly basic N-terminal extension of the mitochondrial matrix enzyme Ornithine transcarbamylase from rat liver.

A leader peptide is sufficient to direct mitochondrial import of a chimeric protein.

A matrix-localized mitochondrial protease processing cytoplasmically made precursors to mitochondrial proteins.

A metalloprotease involved in the processing of mitochondrial precursor proteins.

A mitochondrial protease that cleaves the precursor of Ornithine carbamoyltransferase: Purification and properties.

A neutral metallo endoprotease involved in the processing of an FrATPase subunit precursor in mitochondria.

A nuclear gene encoding the ß subunit of the mitochondrial ATP synthase in Nicotiana plumbaginifolia.

A nuclear mutant of Neurospora crassa lacking subunit 1 of cytochrome c oxidase.

A nuclear mutation prevents processing of a mitochondrially encoded membrane protein in Saccharomyces cerevisiae.

A nuclear mutation that posttranscriptionally blocks accumulation of a yeast mitochondrial gene product can be suppressed by a mitochondrial gene rearrangement.

A purified precursor Polypeptide requires a cytosolic protein fraction for import into mitochondria.

A synthetic signal peptide blocks import of precursor proteins destined for the mitochondrial inner membrane or matrix.

A water-soluble form of porin from the mitochondrial outer membrane of Neurospora crassa.

A yeast mutant temperature-sensitive for mitochondrial assembly is deficient in a mitochondrial protease activity that cleaves imported precursor Polypeptides.

Amino-terminal deletions in the presequence of an imported mitochondrial protein block the targeting function and proteolytic cleavage of the presequence at the carboxy terminus.

An mRNA maturase is encoded by the first intron of the mitochondrial gene for the subunit I of cytochrome oxidase in S.

Analysis of a yeast nuclear gene involved in the maturation of mitochondrial pre-messenger RNA of the cytochrome oxidase subunit I.

Analysis of membrane surface protein sequences with the hydrophobic moment plot.

Antibodies against a fused 7#cZ-yeast mitochondrial intron' gene product allow identification of the mRNA maturase encoded by the fourth intron of the yeast cob-box gene.

Antibodies against synthetic Oligopeptides allow identification of the mRN A-maturase encoded by the second intron of the yeast coh-hox gene.

Are all mitochondrial translation products synthesized on membrane-bound ribosomes?

Arginine in the leader peptide is required for both import and proteolytic cleavage of a mitochondrial precursor.

Artificial mitochondrial presequences.

Assembly of cytochrome c. Apocytochrome c is bound to specific sites on mitochondria before its conversion to holocytochrome c.

Assembly of the mitochondrial membrane System: CBP6, a yeast nuclear gene necessary for synthesis of cytochrome h.

Assembly of the mitochondrial membrane System: CBPI, a yeast nuclear gene involved in 5' processing of cytochrome h pre-mRNA.

Assembly of the mitochondrial membrane System: Characterization of a yeast nuclear gene involved in the processing of the cytochrome b pre-mRNA.

Assembly of the mitochondrial membrane System: DNA sequence of subunit 2 of yeast cytochrome oxidase.

Assembly of the mitochondrial membrane System: The DNA sequence of a mitochondrial ATPase gene in Saccharomyces cerevisiae.

Assembly of the mitochondrial membrane System: VI. Mitochondrial synthesis of subunit proteins of the rutamyein-sensitive adenosine triphosphatase.

Biogenesis of a 35-kilodalton protein associated with outer mitochondrial membrane in rat liver.

Biogenesis of cytochrome c in Neurospora crassa: Synthesis of apocytochrome c, transfer to mitochondria and conversion to holocytochrome c.

Biogenesis of mitochondrial ubiquinol:cytochrome e reductase (cytochrome bcx complex).

Biosynthesis and topogenesis of aspartate aminotransferase isoenzymes in chicken embryo fibroblasts: The precursor of the mitochondrial isoenzyme is either imported into mitochondria or degraded in the cytosol.

Biosynthesis of mitochondrial porin and insertion into the outer mitochondrial membrane of Neurospora crassa.

Biosynthesis of the ubiquinol-cytochrome c reductase complex in yeast. Discoordinate synthesis of the Il-kd subunit in response to increased gene copy number.

Biosynthesis of the yeast mitochondrial H~-ATPase complex. In &quot;The Enzymes of Biological Membranes&quot;

Biosynthetic pathway of mitochondrial ATPase subunit 9 in Neurospora crassa.

Both ATP and an energized inner membrane are required to import a purified precursor protein into mitochondria.

cDNA-derived amino acid sequence of rat mitochondrial 3-oxyacyl-CoA thiolase with no transient presequence: Structural relationship with peroxisomal isozyme.

Cell-free synthesis of cytochrome c.

Cell-free synthesis of the mitochondrial ADP/ATP carrier protein of Neurospora crassa.

Cell-free synthesis of ubiquinonebinding protein of mitochondrial cytochrome bc\ complex.

Characterization and derivation of the gene coding for mitochondrial carbamoyl phosphate synthase I of rat.

Characterization of a protease apparently involved in processing of pre-ornithine transcarbamylase of rat liver.

Characterization of a yeast nuclear gene (MST!) coding for the mitochondrial threonyl-tRNA| synthetase.

Characterization of translocation sites involved in the import of mitochondrial proteins.

Chemical and physical fixation of isolated mitochondria in lowenergy and high-energy states.

Cloning and characterization of the yeast nuclear gene for subunit 5 of cytochrome oxidase.

Cloning and expression of the fhc Operon encoding the FeS protein, cytochrome /; and cytochrome f| from the Rhodopseudomonas sphaeroides blcx complex.

Cloning and sequence analysis of a cDNA encoding porcine mitochondrial aspartate aminotransferase precursor.

Complete cDNA-derived amino acid sequence of rat brown fat uncoupling protein.

Complete nucleotide and derived amino acid sequence of cDNA encoding the mitochondrial uncoupling protein of rat brown adipose tissue: Lack of a mitochondrial targeting presequence.

COX8, the structural gene for yeast cytochrome c oxidase subunit VIII.

Cytochrome c2 is not essential for photosynthetic growth of Rhodopseitdomonas capsulata.

Cytoplasmic-type 80 S ribosomes associated with yeast mitochondria: I. Evidence for ribosome binding sites on yeast mitochondria.

Cytoplasmic-type 80 S ribosomes associated with yeast mitochondria: II. Evidence for the association of cytoplasmic ribosomes with the outer mitochondrial membrane in situ.

Cytoplasmically made subunits of yeast mitochondrial FrATPase and cytochrome c oxidase are synthesized as individual precursors, not as polyproteins.

Deficiency in mRNA splicing in a 744 Donald W. Nicholson and Walter Neupert cytochrome c mutant of Neurospora crassa: Importance of carboxy terminus for import of apocytochrome c into mitochondria.

Different transport pathways of individual precursor proteins in mitochondria.

Disruption of the outer membrane restores protein import to trypsin-treated yeast mitochondria.

Distinct steps in the import of ADP/ATP carrier into mitochondria.

Effects of synthetic model peptides resembling the extension peptides of mitochondrial enzyme precursors on import of the precursors into mitochondria.

Efficient splicing of two yeast mitochondrial introns controlled by a nuclear-encodeÜ maturase.

Energy-dependent processing of cytoplasmically made precursors to mitochondrial proteins.

Energydependent translocation of the precursor of Ornithine transcarbamylase by isolated rat liver mitochondria.

Estimation of membrane potential and pH difference across the cristae membrane of rat liver mitochondria.

Expression of the &quot;split gene&quot; coh in yeast mtDNA: Nuclear mutations specifically block the excision of different introns from its primary transcript.

Expression of the split gene coh in yeast: Evidence for a precursor of a &quot;maturase&quot; protein translated from inton 4 and preceeding exons.

Formation of an iso-1-cytochrome c-like species containing a covalently bonded heme group from the apoprotein by a yeast cell-free System in the presence of hemin.

Heme a induces assembly of rat liver cytochrome c oxidase subunits I-III in isolated mitochondria.

Heme is necessary for the accumulation and 17. Synthesis and Assembly of Mitochondrial Proteins 743 assembly of cytochrome c oxidase subunits in Saccharomyces cerevisiae.

High-affinity binding sites involved in the import of porin into mitochondria.

How mitochondria import proteins from the cytoplasm.

How mitochondria import proteins.

How proteins are transported into mitochondria.

How proteins find mitochondria and intramitochondrial compartments.

Human FrATPase: Molecular cloning of cDNA for the ß subunit.

Identification of an outer mitochondrial membrane protein that interacts with a synthetic signal peptide.

Identification of two products of mitochondrial protein synthesis associated with mitochondrial adenosine triphosphatase from Neurospora crassa.

Impaired binding of mitochondrial adenosine triphosphatase in the cytoplasmic &quot;petite&quot; mutant of Saccharomyces cerevisiae.

Import and processing of cytochrome b-cx complex 738 Donald W. Nicholson and Walter Neupert subunits in isolated hepatoma ascites cells: Inhibition by rhodamine 6G.

Import and processing of hybrid proteins by mammalian mitochondria in vitro.

Import of an incompletely folded precursor protein into isolated mitochondria requires an energized inner membrane, but no added ATP.

Import of cytochrome e into mitochondria: Cytochrome e heme lyase.

Import of proteins into mitochondria: A 70 kilodalton outer membrane protein with a large carboxy-terminal deletion is still transported to the outer membrane.

Import of proteins into mitochondria: Cytochrome h2 and cytochrome c peroxidase are located in the intermembrane space.

Import of proteins into mitochondria: Energy-dependent uptake of precursors by isolated mitochondria.

Import of proteins into mitochondria: Energy-dependent, two-step processing of the intermembrane Space enzyme cytochrome h2 by isolated yeast mitochondria.

Import of proteins into mitochondria: Extramitochondrial pools and posttranslational import of mitochondrial protein precursors in vivo.

Import of proteins into mitochondria: Import and maturation of the mitochondrial intermembrane space enzymes cytochrome b2 and cytochrome c peroxidase in intact yeast cells.

Import of proteins into mitochondria: In vitro studies on the biogenesis of the outer membrane.

Import of proteins into mitochondria: Isolated yeast mitochondria and a solubilized matrix protease correctly process cytochrome c oxidase subunit V at the NH2 terminus.

Import of proteins into mitochondria: Nucleotide sequence of the gene for a 70-kd protein of the yeast mitochondrial outer membrane.

Import of proteins into mitochondria: Partial purification of a matrix-located protease involved in cleavage of mitochondrial precursor Polypeptides.

Synthesis and assembly of mitochondrial proteins

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Synthesis and assembly of mitochondrial proteins

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