Baumeister, Rüdiger

Krumbach, J.

Seifert, J.

Wiebecke, B.

English

Universität München: Elektronischen Publikationen

Y H l . J . ^7 9 I7Ü1 
European Surgical Research 
Clinical and Experimental Surgery 
Editors-in-Chief 
W. Brendel, Munich 
K. Messmer, Heidelberg 
Editorial Board 
R. Benichoux, Nancy 
S.-E. Bergentz, Malmö 
J.L. Berk, Cleveland, Ohio 
R.Y. Calne, Cambridge 
H.A.F. Dudley, London 
U.F. Gruber, Basel 
R.O. Heimbecker, London, Ont. 
F. Largiader, Zurich 
J.-N. Maillard, Colombes 
N.A. Matheson, Aberdeen 
S. Karger Basel • München Paris London • New York • Sydney 
Contents Vol. 13,1981 
U«lv*r$ltatt-
No A 
European Society for Surgical Research. 16th Congress, Garmisch-Partenkirchen 1981 
Abstracts 
Editors: K. Messmer, R. Schosser, H. Zeintl 
No. 2 
Original Papers 
Experimental Evidence against the Bile Salt Theory of Colon Carcinogenesis 
Cruse, J.P.; Lewin, M.R.; Ferulano, G.P.; Clark, C G 117 
Gastric Morphological and Functional Changes Produced by Bile in the Canine Stomach 
Thomas, W.E.G 125 
Effect of Selective Proximal and Truncal Vagotomy on Canine Gallbladder Bile Composition 
Meijer, S.; Visser, J.J.; Rauwerda, J.; Hoitsma, H.F.W 134 
Chlorpromazine Treatment of Experimental Acute Fulminant Pancreatitis in Pigs 
Schroder, T.; Lempinen, M ; Nordling, S.; Kinnunen, P.K.J 143 
Clotting and Other Plasma Factors in Experimental Endotoxemia: Inhibition of Degradation by 
Exogenous Proteinase Inhibitors 
Jochum, M.; Witte, J.; Schiessler, H.; Selbmann, H.K.; Ruckdeschl, G.; Fritz, H 152 
Oxidative Phosphorylation, Enzyme Induction and Rat Liver Regeneration: Effect of Phenobarbital 
Ngala Kenda, J.F.; Lambotte, L 169 
Adenine Nucleotide Levels of Canine Kidneys during Hypothermic Aerobic or Anaerobic Storage in 
Collins' Solution 
Fischer, J.H.; Kulus, D.; Hansen-Schmidt, I.; Isselhard, W 178 
No. 3 
Original Papers 
Pedunculated Vagally Innervated Lesser Curve Gastric Pouch in Dogs 
Amdrup, E.; Ornsholt, J 189 
Healing of Incisional Wounds in Stomach and Duodenum. Collagen Synthesis 
Danielsen, C.C.; Gottrup, F 194 
Experimental and Clinical Studies on Continent Colostomy 
Schmidt, E.; Bruch, H.-P.; Romen, W.; Rothhammer, A 202 
The Effect of SST, Glucagon, Calcitonin and PGEj on Exocrine Pancreatic Secretion in the Unrestrained 
Dog in Long-Term Experiments 
Funovics, J.; Hölbling, N.; Rauhs, R.; Pointner, H.; Niebauer, G.; Walde, L; Kopf, N 213 
Contents III 
Hemodynamic and Morphological Changes in the Stomach of Portal Hypertensive Rats 
Kitano, S.; Inokuchi, K.; Sugimachi, K.; Koyanagi, N. ' 227 
A Simplified Technique for Orthotopic Liver Transplantation in the Rat Using a Cuff Technique for 
Portal Vein and Infrahepatic Vena Cava Anastomoses 
Limmer, J.; Calne, R.Y 236 
Cathepsin D Activity and Protein Degradation Products Content in the Walls of Varicose Veins of the 
Lower Limbs 
Gtowinski, S.; Worowski, K 243 
Optical Properties of Damaged and Undamaged Muscle Tissue Studied in High-Energy Missile 
Wounds 
Hagelin, K.W.; Janzon, B.; Röckert, H.; Seeman, T 247 
No. 4 
Original Papers 
Influence of Hormonal Stimulation by Caerulein on Acute Experimental Pancreatitis in the Rat 
Evander, A.; Ihse, I.; Lundquist, 1 257 
Serum DNase Activity after Experimental, Acute Hemorrhagic-Necrotizing Pancreatitis in Dogs: 
Detection of a Serum DNase Isoenzyme 
Reitz, M.; Neher, M.; Zöllner, E.J.; Zahn, R.K 269 
An Explanation for the Reduction in Bilirubin Levels in Congenitally Jaundiced Gunn Rats after 
Transplantation of Isolated Hepatocytes 
Woods, R.J.; Parbhoo, S.P 278 
Effects of General Anaesthesia on Portal Venous Pressure in the Rat 
Belghiti, J.; Blanchet, L.; Lebrec, D 285 
Defects in Hemostasis Produced by Antibiotics. An in vivo Study in the Rat 
Bengmark, S.; Göransson, G.; Zoucas, E 290 
Microsurgical Vasovasostomy 
Lamesch, A.J.; Dociu, N 299 
Abstracts 
12th Round Table Symposium on Applied Immunology, Axams/Tirol, January 26-29, 1981 310 
No. 5 
Original Papers 
Tissue Hypoxia and Increased Physiological Tissue Shunt Caused by Beta-Adrenergic Stimulation 
Yonekawa, H.; Berk, J.L.; Neumann, M.R.; Liu, C.C 325 
Improvement of the Splenectomized Rat Model for Overwhelming Pneumococcal Infection. 
Standardization of the Bacterial Inocula 
Alwmark, A.; Bengmark, S.; Gullstrand, P.; Schalen, C 339 
Viability of Canine Lung after Temporary Ischemia under Cooling. An Electron Microscopy Study 
Harada, K.; Fukuda, T.; Inoue, K 344 
Use of Non-Heart-Beating Donor Kidneys for Transplantation 
Vliet, J.A. van der; Slooff, M.J.H.; Rijkmans, B.G.; Kootstra, G 354 
IV Contents 
Effect of Pancreas Transplantation on Plasma Lipids and Plasma Concentrations of Pancreatic 
Hormones in Streptozotocin Diabetic Rats 
Brekke, LB.; Hostmark, A.T.; Flaten, O.; 0yasaeter, S 361 
Gastric Cancer after Vagotomy and Excision for Gastric Ulcer 
Haukland, H.; Johnson, J.A 371 
Continuous Registration of Blood Velocity and Cardiac Output with a Hot-Film Anemometer Probe, 
Mounted on a Swan-Ganz Thermodilution Catheter 
Paulsen, P.K.; Andersen, M 376 
Cartilage Formation from Perichondrium in a Weight-Bearing Joint. An Experimental Study 
Kon, M 387 
No. 6 
Original Papers 
Effect of Peritoneal Trauma on Peritoneal Fibrinolytic Activity and Intraperitoneal Adhesion Formation. 
An Experimental Study in the Rat 
Raftery, A.T 397 
Pulmonary Insufficiency in the Rat after Intravascular Coagulation and Inhibition of Fibrinolysis. 
I. Studies on Some Pathogenetic Mechanisms 
Gerdin, B.; Diffang, C ; Saldeen T 402 
Mechanical Ventilation as a Pump for the Pulmonary Circulation 
Sade, R.M.; DeWet Lübbe, J.J.; Simpser, M.D.; Strieder, D.J 414 
Imbalance in Brush Border Enzyme Activities as a Possible Cause of Hepatic Dysfunction after 
Jejunoileal Bypass in the Rat 
Marescaux, J.; Stock, C ; Vasseur, M.; Raul, F.; Doffoel, M.; Grenier, J.F 427 
Prolonged Hypocholesteremic Effect of Portacaval Transposition in Dogs. An Experimental Study 
Castellanos, J.; Toledo-Pereyra, L.H.; Mittal, V.K.; Guzman, I.; Lillehei, R.C 438 
Circulating Hepatodepressant Factors Decreasing the Energy Charge Levels of the Remnant Liver after 
Hepatectomy 
Ozawa, K.; Yamaoka, Y.; Kimura, K.; Kamiyama, Y.; Sato, M.; Ukikusa, M.; Tobe, T 444 
Neuroauxological Effect of the Rat Salivary Gland on the Central Stump of Corneal Nerves 
Craviotto, C ; Baldini, M 458 
Author Index 465 
Subject Index 467 
Drug Dosage 
The authors and the publisher have exerted every effort to 
ensure that drug selection and dosage set forth in this text 
are in accord with current recommendations and practice 
at the time of publication. However, in view of ongoing 
research, changes in government regulations, and the 
constant flow of information relating to drug therapy and 
drug reactions, the reader is urged to check the package 
insert for each drug for any change in indications and dos-
age and for added warnings and precautions. This is par-
ticularly important when the recommended agent is a 
new and/or infrequently employed drug. 
All rights reserved. 
No part of this publication may be translated into other 
languages, reproduced or utilized in any form or by any 
means, electronic or mechanical, including photocopy-
ing, recording, microcopying, or by any information stor-
age and retrieval system, without permission in writing 
from the publisher. 
S. Karger AG, P.O. Box, CH-4009 Basel (Switzerland) 
Printed in Switzerland by 
Thür AG Offsetdruck, Pratteln 
16th Congress, Garmisch-Partenkirchen, April 26-29, 1981 
European Society for Surgical Research 
Abstracts 
Editors: 
K. Messmer, R. Schosser, H. Zeintl 
S. Karger Basel München • Paris • London • New York Sydney 
40 European Surgical Research 
54 Lymph Vessel Transplantation for the Treatment of 
Experimental Lymphedema in Dogs 
RXi.Il. Baumeister, J. Seifen. B. Wiebecke. 
J. Krumhach 
The aim of ihe investigation was to develop a causal 
therapy for the secondary lymphostatic edema due to a 
regional blockage of the lymphatic system. A reconstruc-
tion of the blocked lymph vessels is only possible by lymph 
vessels, as can be seen from the literature. 
Therefore an experimental lymphedema in dogs was 
treated by autologous transplantation of lymph collectors. 
The edema was produced according to the Clodius model 1 
with a total blockage of the deep and superficial lymphatic 
system of the hind leg on dogs. After induction of the 
lymphedema the circumference of the leg rose during 
8 days at about 50%. After microsurgical autologous 
lymph vessel transplantation with tension-free anastomos-
ing technique the circumference diminished to a remaining 
difference of 10%. To check the lymphedema model the 
successfully transplanted lymph vessels were removed to 
see whether a lymphedema could be observed again. When 
the transplants were removed, values as before the trans-
plantation were reached, indicating that a transplanted 
lymph vessel is able to treat an experimental lymphedema. 
The intralymphatic pressure of normally 2.5 torr was ele-
vated during the phase of edema at 12.5 torr and was in the 
range of the normals after the transplantation. 
The patency of the transplants were proved by inspec-
tion, lymphography, injection of dyes and isotopes, and by 
histological examinations. In all 10 dogs at least one open 
Abstracts 41 
transplant could be detected histologically. By lymph ves-
sel transplantation it is possible to treat successfully an 
experimental lymphedema in dogs. 
This is a promising method also for the treatment of a 
secondary lymphostatic edema in man. 
Institute for Surgical Research. Klinikum 
Grosshadcrn. University of Munich, 
Marchioninistrasse 15. D - 8 0 0 0 München 70 (FRG) 


Lymph vessel Transplantation for the treatment of experimental lymphedema in dogs.

Open Access LMU

Y H l . J . ^7 9 I7Ü1 European Surgical Research Clinical and Experimental Surgery Editors-in-Chief W. Brendel, Munich K. Messmer, Heidelberg Editorial Board R. Benichoux, Nancy S.-E. Bergentz, Malmö J.L. Berk, Cleveland, Ohio R.Y. Calne, Cambridge H.A.F. Dudley, London U.F. Gruber, Basel R.O. Heimbecker, London, Ont. F. Largiader, Zurich J.-N. Maillard, Colombes N.A. Matheson, Aberdeen S. Karger Basel • München Paris London • New York • Sydney Contents Vol. 13,1981 U«lv*r$ltatt-No A European Society for Surgical Research. 16th Congress, Garmisch-Partenkirchen 1981 Abstracts Editors: K. Messmer, R. Schosser, H. Zeintl No. 2 Original Papers Experimental Evidence against the Bile Salt Theory of Colon Carcinogenesis Cruse, J.P.; Lewin, M.R.; Ferulano, G.P.; Clark, C G 117 Gastric Morphological and Functional Changes Produced by Bile in the Canine Stomach Thomas, W.E.G 125 Effect of Selective Proximal and Truncal Vagotomy on Canine Gallbladder Bile Composition Meijer, S.; Visser, J.J.; Rauwerda, J.; Hoitsma, H.F.W 134 Chlorpromazine Treatment of Experimental Acute Fulminant Pancreatitis in Pigs Schroder, T.; Lempinen, M ; Nordling, S.; Kinnunen, P.K.J 143 Clotting and Other Plasma Factors in Experimental Endotoxemia: Inhibition of Degradation by Exogenous Proteinase Inhibitors Jochum, M.; Witte, J.; Schiessler, H.; Selbmann, H.K.; Ruckdeschl, G.; Fritz, H 152 Oxidative Phosphorylation, Enzyme Induction and Rat Liver Regeneration: Effect of Phenobarbital Ngala Kenda, J.F.; Lambotte, L 169 Adenine Nucleotide Levels of Canine Kidneys during Hypothermic Aerobic or Anaerobic Storage in Collins' Solution Fischer, J.H.; Kulus, D.; Hansen-Schmidt, I.; Isselhard, W 178 No. 3 Original Papers Pedunculated Vagally Innervated Lesser Curve Gastric Pouch in Dogs Amdrup, E.; Ornsholt, J 189 Healing of Incisional Wounds in Stomach and Duodenum. Collagen Synthesis Danielsen, C.C.; Gottrup, F 194 Experimental and Clinical Studies on Continent Colostomy Schmidt, E.; Bruch, H.-P.; Romen, W.; Rothhammer, A 202 The Effect of SST, Glucagon, Calcitonin and PGEj on Exocrine Pancreatic Secretion in the Unrestrained Dog in Long-Term Experiments Funovics, J.; Hölbling, N.; Rauhs, R.; Pointner, H.; Niebauer, G.; Walde, L; Kopf, N 213 Contents III Hemodynamic and Morphological Changes in the Stomach of Portal Hypertensive Rats Kitano, S.; Inokuchi, K.; Sugimachi, K.; Koyanagi, N. ' 227 A Simplified Technique for Orthotopic Liver Transplantation in the Rat Using a Cuff Technique for Portal Vein and Infrahepatic Vena Cava Anastomoses Limmer, J.; Calne, R.Y 236 Cathepsin D Activity and Protein Degradation Products Content in the Walls of Varicose Veins of the Lower Limbs Gtowinski, S.; Worowski, K 243 Optical Properties of Damaged and Undamaged Muscle Tissue Studied in High-Energy Missile Wounds Hagelin, K.W.; Janzon, B.; Röckert, H.; Seeman, T 247 No. 4 Original Papers Influence of Hormonal Stimulation by Caerulein on Acute Experimental Pancreatitis in the Rat Evander, A.; Ihse, I.; Lundquist, 1 257 Serum DNase Activity after Experimental, Acute Hemorrhagic-Necrotizing Pancreatitis in Dogs: Detection of a Serum DNase Isoenzyme Reitz, M.; Neher, M.; Zöllner, E.J.; Zahn, R.K 269 An Explanation for the Reduction in Bilirubin Levels in Congenitally Jaundiced Gunn Rats after Transplantation of Isolated Hepatocytes Woods, R.J.; Parbhoo, S.P 278 Effects of General Anaesthesia on Portal Venous Pressure in the Rat Belghiti, J.; Blanchet, L.; Lebrec, D 285 Defects in Hemostasis Produced by Antibiotics. An in vivo Study in the Rat Bengmark, S.; Göransson, G.; Zoucas, E 290 Microsurgical Vasovasostomy Lamesch, A.J.; Dociu, N 299 Abstracts 12th Round Table Symposium on Applied Immunology, Axams/Tirol, January 26-29, 1981 310 No. 5 Original Papers Tissue Hypoxia and Increased Physiological Tissue Shunt Caused by Beta-Adrenergic Stimulation Yonekawa, H.; Berk, J.L.; Neumann, M.R.; Liu, C.C 325 Improvement of the Splenectomized Rat Model for Overwhelming Pneumococcal Infection. Standardization of the Bacterial Inocula Alwmark, A.; Bengmark, S.; Gullstrand, P.; Schalen, C 339 Viability of Canine Lung after Temporary Ischemia under Cooling. An Electron Microscopy Study Harada, K.; Fukuda, T.; Inoue, K 344 Use of Non-Heart-Beating Donor Kidneys for Transplantation Vliet, J.A. van der; Slooff, M.J.H.; Rijkmans, B.G.; Kootstra, G 354 IV Contents Effect of Pancreas Transplantation on Plasma Lipids and Plasma Concentrations of Pancreatic Hormones in Streptozotocin Diabetic Rats Brekke, LB.; Hostmark, A.T.; Flaten, O.; 0yasaeter, S 361 Gastric Cancer after Vagotomy and Excision for Gastric Ulcer Haukland, H.; Johnson, J.A 371 Continuous Registration of Blood Velocity and Cardiac Output with a Hot-Film Anemometer Probe, Mounted on a Swan-Ganz Thermodilution Catheter Paulsen, P.K.; Andersen, M 376 Cartilage Formation from Perichondrium in a Weight-Bearing Joint. An Experimental Study Kon, M 387 No. 6 Original Papers Effect of Peritoneal Trauma on Peritoneal Fibrinolytic Activity and Intraperitoneal Adhesion Formation. An Experimental Study in the Rat Raftery, A.T 397 Pulmonary Insufficiency in the Rat after Intravascular Coagulation and Inhibition of Fibrinolysis. I. Studies on Some Pathogenetic Mechanisms Gerdin, B.; Diffang, C ; Saldeen T 402 Mechanical Ventilation as a Pump for the Pulmonary Circulation Sade, R.M.; DeWet Lübbe, J.J.; Simpser, M.D.; Strieder, D.J 414 Imbalance in Brush Border Enzyme Activities as a Possible Cause of Hepatic Dysfunction after Jejunoileal Bypass in the Rat Marescaux, J.; Stock, C ; Vasseur, M.; Raul, F.; Doffoel, M.; Grenier, J.F 427 Prolonged Hypocholesteremic Effect of Portacaval Transposition in Dogs. An Experimental Study Castellanos, J.; Toledo-Pereyra, L.H.; Mittal, V.K.; Guzman, I.; Lillehei, R.C 438 Circulating Hepatodepressant Factors Decreasing the Energy Charge Levels of the Remnant Liver after Hepatectomy Ozawa, K.; Yamaoka, Y.; Kimura, K.; Kamiyama, Y.; Sato, M.; Ukikusa, M.; Tobe, T 444 Neuroauxological Effect of the Rat Salivary Gland on the Central Stump of Corneal Nerves Craviotto, C ; Baldini, M 458 Author Index 465 Subject Index 467 Drug Dosage The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dos-age and for added warnings and precautions. This is par-ticularly important when the recommended agent is a new and/or infrequently employed drug. All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopy-ing, recording, microcopying, or by any information stor-age and retrieval system, without permission in writing from the publisher. S. Karger AG, P.O. Box, CH-4009 Basel (Switzerland) Printed in Switzerland by Thür AG Offsetdruck, Pratteln 16th Congress, Garmisch-Partenkirchen, April 26-29, 1981 European Society for Surgical Research Abstracts Editors: K. Messmer, R. Schosser, H. Zeintl S. Karger Basel München • Paris • London • New York Sydney 40 European Surgical Research 54 Lymph Vessel Transplantation for the Treatment of Experimental Lymphedema in Dogs RXi.Il. Baumeister, J. Seifen. B. Wiebecke. J. Krumhach The aim of ihe investigation was to develop a causal therapy for the secondary lymphostatic edema due to a regional blockage of the lymphatic system. A reconstruc-tion of the blocked lymph vessels is only possible by lymph vessels, as can be seen from the literature. Therefore an experimental lymphedema in dogs was treated by autologous transplantation of lymph collectors. The edema was produced according to the Clodius model 1 with a total blockage of the deep and superficial lymphatic system of the hind leg on dogs. After induction of the lymphedema the circumference of the leg rose during 8 days at about 50%. After microsurgical autologous lymph vessel transplantation with tension-free anastomos-ing technique the circumference diminished to a remaining difference of 10%. To check the lymphedema model the successfully transplanted lymph vessels were removed to see whether a lymphedema could be observed again. When the transplants were removed, values as before the trans-plantation were reached, indicating that a transplanted lymph vessel is able to treat an experimental lymphedema. The intralymphatic pressure of normally 2.5 torr was ele-vated during the phase of edema at 12.5 torr and was in the range of the normals after the transplantation. The patency of the transplants were proved by inspec-tion, lymphography, injection of dyes and isotopes, and by histological examinations. In all 10 dogs at least one open Abstracts 41 transplant could be detected histologically. By lymph ves-sel transplantation it is possible to treat successfully an experimental lymphedema in dogs. This is a promising method also for the treatment of a secondary lymphostatic edema in man. Institute for Surgical Research. Klinikum Grosshadcrn. University of Munich, Marchioninistrasse 15. D - 8 0 0 0 München 70 (FRG) 

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Lymph vessel Transplantation for the treatment of experimental lymphedema in dogs.

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