Grothe, Benedikt

Sanes, Dan H.

English

Open Access LMU

A circuit for detection of interaural time differences in the brain stem of the barn owl.

A circuit for interaural time differences in the chick brainstem.

A pharmacological study of the depression of spinal neurons by glycine and related amino acids.

A place theory of sound localization.

An experimental study of the cells and connections of the superior olivary complex of the cat.

An in vitro analysis of sound localization mechanisms in the gerbil lateral superior olive.

Binaural interaction in the accessory superior olivary nucleus in the cat.

Binaural properties of single units in the superior olivary complex of the mustache bat.

Classification of the principal cells of the B.

Coincidence model of MSO responses.

Fiber degeneration following lesions in the anterior ventral cochlear nucleus of the cat.

GABAergic neurons and axon terminals in the brainstem auditory nuclei of the gerbil.

Glycine immunoreactivity localized in the cochlear nucleus and the superior olivary complex.

Immunohistochemical evidence for inhibitory and disinhibitory circuits in the superior olive.

Inhibitory action of glycine on spinal neurons in the cat.

Interaural time and intensity coding in superior olivary complex and inferior colliculus of the echolocating bat Molossus ater.

Interaural time sensitivity in medial superior olive of cat.

Monaural interaction of excitation and inhibition in the medial superior olive of the mustached bat: an adaptation for biosonar.

Neuroanatomical distribution of receptors for three potential inhibitory neurotransmitters in the brainstem auditory nuclei of the cat.

Neuronal map of interaural phase differences in the owl's brainstem.

Pharmacology of cortical inhibition.

Processing of binaural stimuli by cat superior olivary complex neurons.

Projections from the lateral nucleus of the trapezoid body to the medial olivary nucleus in the gerbil.

Quantitative distribution of the glycine receptor in the auditory brain stem of the gerbil.

Response of binaural neurons of the dog superior olivary complex to dichotic tonal stimuli: some physiological mechanisms of sound localization.

Responses elicited from medial superior olivary neurons by stimuli associated with binaural masking and unmasking.

Some neural mechanisms in the inferior colliculus in the cat which may be relevant to localization of a sound source.

Sound localization: effects of unilateral lesions in central auditory system.

Strychnine blocks binaural inhibition in lateral superior olivary complex.

Synaptic connections in the dorsal cochlear nucleus of mice, in vitro.

Synaptic pharmacology of the superior olivary complex studied in the mouse brain slice.

The dual effect of membrane potential on sodium conductance in the giant axon of Loligo.

The inhibitory suppression of reflex discharges from motoneurones.

The time courses of excitatory and inhibitory synaptic actions.

Versuch einer Definition des medialen Kernes des oberen Olivenkomplexes bei der Neuweltfledermaus Pteronotus p. parnellii (PhD dissertation).

Vesicle shape versus synapse in the nerve endings in the cat medial superior olive.

Bilateral inhibition by glycinergic afferents in the medial superior olive

 1. Coincidence-detection of excitatory synaptic potentials has long been considered to be the mechanism by which medial superior olivary (MSO) neurons compute interaural time differences. Here we demonstrate the contribution of synaptic inhibition in this circuit using a gerbil brain slice preparation. 2. Nearly all cells exhibited excitatory postsynaptic potentials (EPSPs) and action potentials (APs) after stimulation of either the ipsilateral or contralateral afferent pathway. In 44% of cells, the latency of APs depended on stimulus amplitude, exhibiting shifts of 0.25-2 ms. 3. Nearly all neurons (89%) exhibited stimulus-evoked synaptic inhibition. The inhibitory effects were enhanced at greater stimulus amplitudes and were usually able to block synaptically evoked APs. In addition, APs and EPSPs were reversibly blocked by delivering the inhibitory transmitter glycine in almost all tested cells (91%). 4. In the presence of the glycine antagonist strychnine, the effects of synaptic inhibition were suppressed. 5. The stimulus level-dependent inhibitory potentials influenced the probability that an MSO neuron would fire an AP, as well as the precise timing. Therefore, the present results have implications for the processing of interaural time differences by the MSO and at higher auditory centers. </jats:p

Bilateral inhibition by glycinergic afferents in the medial superior olive

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