Niaz, K. (Kamal)

Spoor, J. (Jonathan)

Zaplatic, E. (Elizabeta)

Erasmus University Digital Repository

EXCLI Journal 2018;17:721-723 – ISSN 1611-2156 Received: June 17, 2018, accepted: July 23, 2018, published: July 25, 2018   721 Guest editorial HIGHLIGHT REPORT:  DIPLOPTERA FUNCTATA (COCKROACH) MILK AS  NEXT SUPERFOOD  Kamal Niaz1,*, Elizabeta Zaplatic1, Jonathan Spoor2  1 Faculty of Bioscience and Agro-Food and Environmental Technology, University of Teramo, 64100, Italy 2 Erasmus University Medical Centre, Erasmus University Rotterdam, Rotterdam,  the Netherlands  * Corresponding author: Kamal Niaz, Faculty of Bioscience and Agro-Food and  Environmental Technology, University of Teramo, Italy, Tel # +393207825463,  E-mail: kamalniaz1989@gmail.com     http://dx.doi.org/10.17179/excli2018-1437  This is an Open Access article distributed under the terms of the Creative Commons Attribution License  (http://creativecommons.org/licenses/by/4.0/).   Milk is a rich source of nutrients and considered by many as a valuable element of a complete diet. Traditional mammalian milk such as cow’s milk contains many bioactive components that boost the physiological pro-cesses in the body. The majority of the bio-active constituents of milk are proteins such as immunoglobulins, lactoferrin and other peptides obtained from the hydrolysis of pro-teins. Milk however also contains fatty acids such as linoleic acid and oleic acid, minerals, different oligosaccharides and melatonin (Andreas et al., 2015; Wendorff and Haen-lein, 2017). Apart from its well-known health benefits, milk is sometimes associated with less favourable effects. Allergy, com-monly occurring in children, is one of these. Luckily this problem can be eliminated by removal of beta-lactoglobulin (β-LG). This is achieved with the help of lactic acid bacteria that are capable of hydrolysing immunoreac-tive proteins in milk (Biscola et al., 2018). Further drawbacks to milk as a consumption good are mostly related to procedures neces-sary to its preservation. Over the last dec-ades, genetic engineering has been employed in the production of novel super foods that are gradually beginning to claim their place among traditional foods. A recent study has shown that milk gained from the cockroach species Diploptera functata (D. functata) has a higher nutritional potential than conven-tional mammalian milk. It contains rich stores of essential nutrients such as oleic ac-id, conjugated linoleic acid, omega-3 fatty acids, short-chain and medium-chain fatty acids, vitamins and minerals (Banerjee et al., 2016). In this editorial, light is shed on cock-roach milk as a potential new super food and important alternative to traditional mamma-lian milk that might become available for consumption in the near future. D. functata is a cockroach species known to give birth to live offspring. It has the abil-ity to produce milk in the form of a sub-stance containing protein crystals that serves as nutrition for its young. This so-called ‘cockroach milk’ is a source of N-acetyl-D-glucosamine, β-D-mannose, oleic acid, lino-leic acid and glycerol (Banerjee et al., 2016). Mass spectrometry has identified in these protein crystals the presence of four N-linked EXCLI Journal 2018;17:721-723 – ISSN 1611-2156 Received: June 17, 2018, accepted: July 23, 2018, published: July 25, 2018   722 glycosylation sites, namely Ans35, Ans66, Ans79 and Ans145. This makes it structural-ly and functionally similar to eukaryotic pro-teins (Banerjee et al., 2016). The main gly-can is composed of two N-acetyl-glucosamine molecules and one mannose molecule. The protein crystals produced by this particular insect species (lipocalin-like milk proteins) contain energy stores equiva-lent to approximately 3.7 × 10-5 J. This is three times (232 kcal per 100 g or 37 %) the energy content of milk produced by buffalo’s and other mammals as shown in Figure 1. It has been demonstrated that these crystal pro-teins contain large amounts of vital constitu-ents such as fats, sugar and proteins, and are particularly rich in essential amino acids. Furthermore, it has been shown that during digestion of these crystal proteins, amino ac-ids are released at a continuous rate (Banerjee et al., 2016). Amino corrosive grouping, glycosylation and binding of un-saturated fatty acids in D. functata milk pro-tein crystals are highly heterogeneous (Banerjee et al., 2016). These results in a tight lipocalin overlap and shape the crystals with a firmly stuffed crystalline cross sec-tion. This previously unknown form of stor-age has capabilities to hold molecules more efficiently for a constant supply of nutrients essential to growth and development (Banerjee et al., 2016). The high protein het-erogeneity inside a single in vivo-developed protein crystal, accounts for the super food properties ascribed to cockroach milk.  A recent study conducted in Brazil re-vealed that flour made of another breed of cockroaches, Nauphoeta cinerea (N. ciner-ea), has a protein content far superior to commercial flour acquired from wheat (63.22 % versus 9.8 %). This ‘insect flour’ contains eight essential amino acids and a high quantity of omega-3 (ω-3) and omega-9 (ω-9) fatty acids. Amino acid analysis re-vealed that flour produced from the N. ciner-ea cockroach contains leucine, lysine, and valine at percentages of 3.51, 3.37 and 2.61 % respectively. As for fatty acids, the flour consists of 5.69 % palmatic acid, 9.17 % oleic acid, 7.51 % saturated- and 10.94 % unsaturated fatty acids, all of them acknowledged components of a healthy diet (De Oliveira et al., 2017). It has been sug-gested that normal wheat flower could be amplified with a supplement of cinereous cockroach flour of up to 5 %. This way N. cinerea flour’s benefits could be effectuated without any loss of gustatory quality. Super-foods like the aforementioned cockroach milk and cockroach flour are expected to play a pivotal role in the solution to food shortage in the decades to come (De Oliveira et al., 2017).   Figure 1: Pie chart illustrating energy values per 100 g of milk protein (kcal)   Milk protein crystals and other products produced from cockroaches could be part of a next generation of super foods. Milk is a valued component of the human diet as its nutritional properties enhance human health and quality of life. It is known that milk con-tributes to the prevention of certain diseases and reduces certain threats to health. Several authors mention milk in association with a reduction in risk of cancer, ischaemic heart disease and diabetes (Elfahri et al., 2016; Hayashi et al., 2015; Hove et al., 2015; Lamb et al., 2015; Munblit et al., 2017; O'Shea et al., 2000; Pereira and Vicente, 2018; Shori, 2015; Tsuda et al., 2000; Xiao et al., 2018; Yang et al., 2017; Chen et al., 2014). Needless to say, it is unknown the ex-tent to which cockroach milk shares these qualities with mammalian milk and that will be an important topic for future research. Further investigation should be done to re-232; 37%72; 11%66; 10%110; 17%95; 15%60; 10%kcal (per 100 g)D. functata milkprotein crystalHumanCowWater BuffaloEXCLI Journal 2018;17:721-723 – ISSN 1611-2156 Received: June 17, 2018, accepted: July 23, 2018, published: July 25, 2018   723 veal the exact composition of cockroach milk and the health implications of its con-sumption. Meanwhile, considerable effort is being put into the study of gene sequences of milk protein crystals and different biotechno-logical approaches are being employed for their production. The importance of the iden-tification of protein sequences like that of cockroach milk, can hardly be overestimated. Research into new nutritional strategies will contribute significantly to overcoming food shortages that are expected to arise during the lifetime of generations to come.  Conflict of interest There is no conflict of interest.  Acknowledgements The authors who worked on this manu-script acknowledge their respective universi-ties and institutes.  REFERENCES Andreas NJ, Kampmann B, Le-Doare KM. Human breast milk: a review on its composition and bio-activity. Early Hum Dev. 2015;91:629-35. Banerjee S, Coussens NP, Gallat F-X, Sathyanara-yanan N, Srikanth J, Yagi KJ, et al., Structure of a heterogeneous, glycosylated, lipid-bound, in vivo-grown protein crystal at atomic resolution from the viviparous cockroach Diploptera punctata. IUCrJ. 2016;3(4):282-93. Biscola V, Choiset Y, Rabesona H, Chobert JM, Haertlé T, de Melo Franco BDG. Brazilian artisanal ripened cheeses as sources of proteolytic lactic acid bacteria capable to reduce cow milk allergy. J Appl Microbiol. 2018;125:564-74.  Chen HY, Mollstedt O, Tsai MH, Kreider R. Potential clinical applications of multi-functional milk proteins and peptides in cancer management. Curr Med Chem. 2014;21:2424-37.  De Oliveira LM, da Silva Lucas AJ, Cadaval CL, Mellado MS. Bread enriched with flour from cinereous cockroach (Nauphoeta cinerea). Innov Food Sci Emerg Technol. 2017;44:30-5. Elfahri K, Vasiljevic T, Yeager T, Donkor O. Anti-colon cancer and antioxidant activities of bovine skim milk fermented by selected Lactobacillus helveticus strains. J Dairy Sci. 2016;99:31-40. Hayashi M, Silanikove N, Chang X, Ravi R, Pham V, Baia G, et al. Milk derived colloid as a novel drug delivery carrier for breast cancer. Cancer Biol Ther. 2015;16:1184-93. Hove K, Brøns C, Faerch K, Lund SS, Rossing P, Vaag A. Effects of 12 weeks of treatment with fermented milk on blood pressure, glucose metabolism and markers of cardiovascular risk in patients with type 2 diabetes: a randomised double-blind placebo-controlled study. Eur J Endocrinol. 2015;172:11-20. Lamb MM, Miller M, Seifert JA, Frederiksen B, Kroehl M, Rewers M, et al. The effect of childhood cow's milk intake and HLA‐DR genotype on risk of islet autoimmunity and type 1 diabetes: The Diabetes Autoimmunity Study in the Young. Pediatr Diabetes. 2015;16:31-8. Munblit D, Treneva M, Peroni DG, Colicino S, Chow LY, Dissanayeke S, et al. Immune components in human milk are associated with early infant immuno-logical health outcomes: a prospective three-country analysis. Nutrients. 2017;9(6):E532. O'Shea M, Devery R, Lawless F, Murphy J, Stanton C. Milk fat conjugated linoleic acid (CLA) inhibits growth of human mammary MCF-7 cancer cells. Anticancer Res. 2000;20:3591-601. Pereira PC, Vicente F. Milk nutritive role and potential benefits in human health. In: Watson RR, Collier RH, Preedy VR (eds): Nutrients in dairy and their implications on health and disease (pp 161-76). Amsterdam: Elsevier, 2018. Shori AB. Camel milk as a potential therapy for controlling diabetes and its complications: A review of in vivo studies. J Food Drug Anal. 2015;23:609-18. Tsuda H, Sekine K, Ushida Y, Kuhara T, Takasuka N, Iigo M, et al. Milk and dairy products in cancer prevention: focus on bovine lactoferrin. Mutat Res Rev Mutat Res 2000;462:227-33. Wendorff W, Haenlein GF. Sheep milk - composition and nutrition. In: Park YW, Haenlein GFW, Wendorff WL (eds): Handbook of milk of non‐bovine mammals, 2nd ed. (pp 210-21). Hoboken, NJ: Wiley Blackwell, 2017. Xiao L, van’t Land B, Engen PA, Naqib A, Green SJ, Nato A, et al. Human milk oligosaccharides protect against the development of autoimmune diabetes in NOD-mice. Sci Rep. 2018;8(1):3829. Yang Q, Lin S, Au Yeung SL, Kwok MK, Xu L, Leung GM, et al. Genetically predicted milk consumption and bone health, ischemic heart disease and type 2 diabetes: a Mendelian randomization study. Eur J Clin Nutr. 2017;71:1008-12. 

Highlight report: Diploptera Functata (cockroach) milk as next superfood

Abstract

Similar works

Full text

Available Versions

Erasmus University Digital Repository