Purpose: To present a single-centre experience with endovascular treatment of patients with severe symptoms secondary to acute pulmonary embolism (PE). Material and methods: Twenty-five patients were treated due to contraindications or deficient effects of systemic thrombolytic therapy. The patients were treated with a combination of fragmentation and aspiration, only aspiration, or only fragmentation, and with catheter-directed thrombolytic therapy. Results: The saturation was improved following treatment in all patients, except in one where the procedure could not be completed. There were no immediate or late procedure-related complications. Conclusions: Endovascular treatment of severe PE is a safe and efficient option in patients with failing effect or contraindication to systemic thrombolysis

Bursjoo, Carina

Cwikiel, Wojciech

Keussen, Inger E.

Polish Journal of Radiology

English

Jagiellonian Univeristy Repository

e248© Pol J Radiol 2018; 83: e248-e252DOI: https://doi.org/10.5114/pjr.2018.76785Received: 28.03.2018Accepted: 16.04.2018Published: 01.06.2018 http://www.polradiol.comOriginal paperTreatment of the acute severe pulmonary embolism using endovascular methodsInger E. Keussen1A,B,D,E, Carina Bursjoo1B,D,E,F, Wojciech Cwikiel2A,B,E1Department of Radiology, Lund University, Lund, Sweden2Faculty of Medicine, Department of Clinical Sciences, Lund University, Lund, SwedenAbstractPurpose: To present a single-centre experience with endovascular treatment of patients with severe symptoms sec-ondary to acute pulmonary embolism (PE). Material and methods: Twenty-five patients were treated due to contraindications or deficient effects of systemic throm-bolytic therapy. The patients were treated with a combination of fragmentation and aspiration, only aspiration, or only fragmentation, and with catheter-directed thrombolytic therapy.Results: The saturation was improved following treatment in all patients, except in one where the procedure could not be completed. There were no immediate or late procedure-related complications.Conclusions: Endovascular treatment of severe PE is a safe and efficient option in patients with failing effect or contra-indication to systemic thrombolysis. Key words: endovascular procedure, pulmonary embolism, embolectomy.Correspondence address: Inger E. Keussen, Department of Radiology, Lund University, Getingevägen, 221 85 Lund, Sweden, phone: +46705810710, e-mail: inger.keussen@med.lu.seAuthors’ contribution: A Study design ∙ B Data collection ∙ C Statistical analysis ∙ D Data interpretation ∙ E Manuscript preparation ∙ F Literature search ∙ G Funds collectionIntroduction Acute pulmonary embolism (PE) is a severe condition with a high risk of mortality. The severity of symptoms may vary, but most often include dyspnoea, chest pain, cough, and in some cases haemoptysis. Unstable patients are presented with a drop in blood pressure (BP) and tach-ycardia, and untreated they may progress to circulatory collapse [1]. Following clinical examination and labora-tory tests the diagnosis is commonly verified by echocar-diography (ECO) and/or computer tomography (CT). A pulmonary angiography (PAI) and pulmonary venti-lation/perfusion scan may be performed in specialised hospitals [2-4]. Haemodynamically unstable patients are traditionally treated with systemic thrombolysis or open embolecto-my [5]. However, there are several contraindications for thrombolysis, for instance current or threatening bleed-ing, stroke, recent surgery or delivery, trauma, or malig-nant diseases. For patients with contraindications or insufficient effect of systemic thrombolysis, endovascular treatment may be an option [5-11]. Endovascular methods include catheter-directed administration of thrombolytics (CDT), fragmentation and/or aspiration of emboli, or a combina-tion of these methods. An inferior vena cava (IVC) filter is often placed to prevent further embolisation [12-19].We retrospectively present our results of the endovas-cular treatment in 25 patients with acute, severe PE.Material and methodsOf the 25 patients, 17 were male and eight female, age range 31-83 years. The treatment was performed due to contraindications including gastro-intestinal (G-I) bleed-ing (n = 2), malignancy (n = 4), stroke (n = 3), recent  Treatment of the acute severe pulmonary embolism using endovascular methodse249© Pol J Radiol 2018; 83: e248-e252surgery (n = 3), risk of bleeding (n = 3), recent cardio-pul-monary resuscitation (n = 1), migrating thrombus, and in-sufficient effect of systemic thrombolysis (n = 8) (Table 1).Ten patients presented at the emergency department with dyspnoea and five with chest pain/cardiac arrest. The remaining patients were hospitalised at the time of acute PE due to malignancy, stroke, or palliation. Five patients were haemodynamically unstable with SBP<90 at the time of the procedure. The saturation was moderate or severely decreased in all patients, measuring between 69 and 97% (mean 86%) with oxygen support. The respiratory frequency was measured in 19 patients, with a mean value of 23/min.Echocardiography (ECO) was performed in 20 pa-tients, and 19 or them had signs of right heart strain. The extent of the PE was verified by CT scans in all pa-tients. The Miller Index was used to quantify pulmonary arterial obstruction, with a mean value of 14.6 (patient number = 11, 12, 13, 14, 15, 20).All procedures except one were performed with local anaesthesia, with continuous monitoring of BP, heart rate, and saturation. Following puncture of the right common femoral vein, an IVC filter (Celect, Cook Sweden AB, Askim, Sweden) was positioned in the infrarenal IVC if indicated, to prevent further embolisation. Thereafter, a 70 cm long 9 F introducer was placed with the tip in the IVC close to the right atrium. The tip of a 7 F APC catheter (Cook Sweden AB) was thereafter advanced through the introducer to the left and right main pulmonary arteries and diagnostic angiograms were performed. Subsequently the introducer tip was advanced over a Glidewire (Terumo Sweden AB, Västra Frölunda, Sweden) to the main pulmo-nary trunk. In cases with occlusive central emboli frag-mentation attempt was done using rotation of the tip of a 5 F pigtail catheter (Cordis, Sollentuna, Sweden) placed over the guidewire in the left and/or right pulmonary ar-tery. Following exchange of the guidewire to a 0.018 wire Table 1. Patients and treatmentsPatientnoAge Gender History/Actual problem Indication for endovascular treatment IVC filter Endovascular treatment1 58 M Pulmonary transplant Recent surgery Yes CDT2 64 M Liver malignancy Recent surgery Yes A3 69 M Chest pain + cardiac arrest Insufficient effect of systemic thrombolysis No F + A4 70 M Intracranial haemorrhage Stroke Yes F + A5 70 F Chest pain Risk of bleeding (aorta aneurysm) Yes F + A6 79 M Pneumonia + sepsis Insufficient effect of systemic thrombolysis No F7 42 M Urachus malignancy Malignancy Yes A8 58 F Leiomyosarcoma Malignancy No F + A + CDT9 72 M Dyspnoea Migrating thrombus No F + A10 68 F Dyspnoea GI-bleeding Yes F11 68 F Cardiac arrest Recent CPR Yes F + A12 66 M Cerebral malignancy GI-bleeding Yes F + A13 78 M Dyspnoea Insufficient effect of systemic thrombolysis No F + A14 63 F Stroke + cardiac arrest Stroke Yes F + A15 82 M Dyspnoea Insufficient effect of systemic thrombolysis No F + CDT16 71 M Dyspnoea Insufficient effect of systemic thrombolysis Yes F + A17 61 M Pancreatic malignancy Malignancy No F18 64 M Intracranial haemorrhage Stroke Yes A19 69 M Pneumonia + deep vein thrombosis Risk of bleeding (infection) Yes F + A20 57 M Chest pain + dyspnoea Risk of bleeding (after coronary a i) Yes F21 69 F Dyspnoea Malignancy Yes F + A22 43 F Dyspnoea Insufficient effect of systemic thrombolysis Yes A23 74 M Intracranial surgery Recent surgery Yes F + A24 31 F Recent delivery Insufficient effect of systemic thrombolysis No F + A25 63 M Dyspnoea + cardiac arrest Insufficient effect of systemic thrombolysis Yes F + AA – aspiration, CDT – catheter-directed therapy, CPR – cardio pulmonary resuscitation, F – fragmentationInger E. Keussen, Carina Bursjoo, Wojciech Cwikiel  e250 © Pol J Radiol 2018; 83: e248-e252(Boston Scientific, Helsingborg, Sweden), an Arrow- Trerotola positioned over the wire percutaneous thrombo-lytic device (PTD – Arrow Int. Inc., Reading PA, USA) [20] was advanced into the pulmonary trunk, and fragmenta-tion of the emboli in the main and segmental branches was performed. Aspiration of emboli was done using an 8 F JR4 guiding catheter (Cordis). In three patients CDT was administrated though a 4 F Cobra C2 catheter (Cordis) or a 4 F MPA catheter (Terumo) placed with the tip in the embolus in the main right or left pulmonary ar-tery, using alteplase (Actilyse, Boerhinger Ingelheim AB, Stockholm, Sweden). The results of all the treatments were verified during the procedure by multiple contrast injec-tions and by final angiography (Figure 1A-C). ResultsOne patient in severe, unstable condition and with ex-tensive PE expired during the attempted fragmentation due to circulatory arrest that could not be reversed. The procedures were successfully completed in the other 24 patients. In 17 patients an IVC filter was placed during the procedure. In 14 of the 23 patients fragmentation and aspiration of the emboli were performed. In four patients aspiration only and in another four fragmentation only was performed. CDT alone was performed in one patient, in whom mechanical or systemic treatment was contrain-dicated due to recent surgery (patient 1). In two other patients, CDT was combined with mechanical removal (patient 8 and 15) due to large emboli burden. The final angiography showed improved flow in the pulmonary circulation in all patients. One of these patients was, however, subsequently treated by surgical embolecto-my due to recurrent circulatory instability. The treatment had good primary effect with immediate improvement of saturation in all the other patients, and there were no pro-cedure-related complications (Table 1). The mean time of hospitalisation after the procedure was 12.5 days, including less than half a day of observa-tion in the intensive care unit. Figure 1. A) Emboli in the right pulmonary artery causing perfusion defects. B) Arrow-Trerotola in place in the artery to the lower lobe. C) Result after the endovascular treatment with improvement of the perfusionACB Treatment of the acute severe pulmonary embolism using endovascular methodse251© Pol J Radiol 2018; 83: e248-e252During follow-up (up to 42 months) nine patients ex-pired. One died due to pneumonitis after three days, and one due to anoxia of the brain following heart arrest (re-versed prior to the procedure) after 12 days. One patient expired due to aortic dissection more than one year after treatment, two due to unknown causes after more than six months, and the others later due to underlying disorders.Discussion Acute PE is a severe condition with substantial morbid-ity and mortality (15-18%) within the first three months [21]. Late complications such as chronic thromboembolic pulmonary hypertension may cause significant morbid-ity [22]. The traditional treatment includes anticoagu-lant therapy in haemodynamically stable patients, while unstable patients are treated with systemic thrombolysis or open surgery. Open surgery is an extensive procedure that carries substantial risk of complications [12]. System-ic thrombolysis usually has good effect but contains risks and contraindications, such as ongoing or expected bleed-ing, recent stroke, trauma, surgery or delivery, known gas-trointestinal ulceration, and some malignant diseases. Endovascular treatment of patients with massive PE was reported previously [6-12]. There are several strate-gies of endovascular treatment. A widely used therapy is CDT, where the thrombolytic agent is administrated di-rectly into the embolus, with a potent local effect [12,13]. A percutaneous central PE fragmentation may be done us-ing rotation of, for example, a pigtail catheter. The smaller fragments migrate more peripherally, increasing total pul-monary perfusion and relieving right ventricular afterload, and may augment the effect of the thrombolysis [12,14]. Several different aspiration devices are available, some with combined fragmentation with drug infusion-function [13,15]. Ultrasound-assisted catheter-directed thromboly-sis is another relatively new method, but one that requires treatment lasting about 20 hours [16-19]. We retrospec-tively report our experience of interventional treatment of patients with severe symptoms secondary to massive PE, in which conventional treatment failed or could not be performed.All our patients were severely symptomatic, and system-ic thrombolysis was contraindicated or unsuccessful in all of them. Due to the urgency of the procedures registration of the different parameters such as pulmonary artery pressure was not performed. The procedures had, however, a prima-ry prompt effect with substantial improvement of satura-tion, which persisted during the patients’ hospital stay.Mechanical fragmentation of the PE using intravas-cular methods and devices was previously described [12]. The Arrow-Trerotola PTD is relatively common in the treatment of thrombosed dialysis grafts [20] but may also be used in native fistulas [23] and in peripheral veins [24]. However, to our knowledge use of this device in the treat-ment of PE was not previously reported. For aspiration of the embolic material we used cardiac guiding catheters due to their large inner lumen and good torque ability, allowing easy positioning in more peripheral branches. There were no procedure-related complications. Most of our patients had PE secondary to severe underlying dis-eases, which was the main cause of the prolonged hospital stay after intervention. The causes of deaths were not re-lated to the procedures. We conclude that the treatment of the acute PE using our methods is safe and efficient in the majority of patients and may be recommended. Conflict of interestThe authors report no conflict of interest.Figure 2. Aspirated emboliReferences1. Wood KE. Major pulmonary embolism: review of a pathophysiologic approach to the golden hour of hemodynamically significant pulmo-nary embolism. Chest 2002; 121: 877-905.2. Perrier A, Roy PM, Sanchez O, et al. Multidetector-row computed tomography in suspected pulmonary embolism. N Engl J Med 2005; 352: 1760-1768.3. Kucher N, Rossi E, De Rosa M, et al. Prognostic role of echocardiog-raphy among patients with acute pulmonary embolism and a systolic arterial pressure of 90 mm Hg or higher. Arch Intern Med 2005; 165: 1777-1781.4. Ten Wolde M, Söhne M, Quak E, et al. Prognostic value of echo-cardiographically assessed right ventricular dysfunction in pa-Inger E. Keussen, Carina Bursjoo, Wojciech Cwikiel  e252 © Pol J Radiol 2018; 83: e248-e252tients with pulmonary embolism. Arch Intern Med 2004; 164: 1685-1689.5. Büller HR, Agnelli G, Hull RD, et al. Antithrombotic therapy for venous thromboembolic disease: The seventh ACCP conference on antithrombotic and thrombolytic therpy. Chest 2004; 126: 401-428.6. Dumantepe M, Teymen B, Akturk U, et al. Efficacy of rotational thrombectomy on the mortality of patients with massive and sub-massive pulmonary embolism. J Card Surg 2015; 30: 324-332.7. Lee MY, Kim MY, Han JY, et al. 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Catheter-directed ultrasound-accelerated thrombolysis may be life-saving in patients with massive pulmonary embolism after failed systemic thrombolysis. J Thromb Thrombol-ysis 2016; 42: 322-328.18. Bloomer TL, El-Hayek GE, McDaniel MC. Safety of catheter-direct-ed thrombolysis for massive and submassive pulmonary embolism: results of a multicenter registry and meta-analysis. Catheter Cardi-ovasc Interv 2017; 89: 754-760.19. Mohan PP, Manov JJ, Contreras F, et al. Ultrasound-Assisted Cath-eter-Directed Thrombolysis for Submassive Pulmonary Embolism. Vasc Endovascular Surg 2018; 52: 195-201.20. Trerotola SO, Vesely TM, Lund GB, et al. Treatment of thrombosed hemodialysis access grafts: Arrow-Trerotola percutaneous throm-bolytic device versus pulse-spray thrombolysis. Arrow-Trerotola Percutaneous Thrombolytic Device Clinical Trial. Radiology 1998; 206: 403-414.21. Goldhaber SZ, Visani L, De Rosa M, et al. 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Treatment of the acute severe pulmonary embolism using endovascular methods

Purpose: To present a single-centre experience with endovascular treatment of patients with severe symptoms secondary to acute pulmonary embolism (PE). Material and methods: Twenty-five patients were treated due to contraindications or deficient effects of systemic throbolytic therapy. The patients were treated with a combination of fragmentation and aspiration, only aspiration, only fragmentation, and with catheter-directed thrombolytic therapy. Results: The saturation was improved following treatment in all patients, except in one where the procedure counot be completed. There were no immediate or late procedure-related complications. Conclusions: Endovascular treatment of severe PE is a safe and efficient option in patients with failing effect or contindication to systemic thrombolysis

Lund University Publications

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Treatment of the acute severe pulmonary embolism using endovascular methods

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