Tuberculosis in South American sea lions (Otaria flavescens) - diagnostic options and its epidemiologic importance for other mammals within the zoological garden

Abstract

Tuberculosis is a widely spread zoonotic disease caused by acid-fast bacteria of the Mycobacterium tuberculosis complex in a variety of mammalian species. In pinnipeds, tuberculosis has been reported in different captive and wild sea lions and fur seals. The causative agent, Mycobacterium pinnipedii, is part of the M. tuberculosis complex and has shown pathogenicity in other mammalian species including human beings. Since 2000 the Heidelberg zoo has been dealing with tuberculosis in its collection of South American sea lions (Otaria flavescens). After a Malayan tapir (Tapirus indicus) was transferred to a zoological institution in France it transmitted the disease to the other tapirs that succumbed to tuberculosis. Culturing and spoligotyping confirmed the origin, the sea lions at the Heidelberg zoo. An investigation of the sea lion group housed at Heidelberg in addition to different species of mammals living in adjacent exhibits as well as a sea lion, born in Heidelberg but then living in Hamburg, revealed multiple cases of pinniped tuberculosis