Recently, the mesh free methods (radial basis functions-RBFs) have emerged as a novel computing method in the scientific and engineering computing community. The numerical solution of partial differential equations (PDEs) has been usually obtained by finite difference methods (FDM), finite element methods (FEM) and boundary elements methods (BEM). These conventional numerical methods still have some drawbacks. For example, the construction of the mesh in two or more dimensions is a nontrivial problem. Solving PDEs using radial basis function (RBF) collocations is an attractive alternative to these traditional methods because no tedious mesh generation is required. We compare the mesh free method, which uses radial basis functions, with the traditional finite difference scheme and analytical solutions. We will present some examples of using RBFs in geostatistical analysis of radionuclide migration modeling. The advection-dispersion equation will be used in the Eulerian and Lagrangian forms. Stefan's or moving boundary value problems will also be presented. The position of the moving boundary will be simulated by the moving data centers method and level set method