Bas, Yasemin

Croubels, Siska

De Saeger, Sarah

Devreese, Mathias

Huybrechts, B

Meerpoel, Celine

Tangni, E

Vidal Corominas, Arnau

English

Ghent University Academic Bibliography

ObjectivesMethod validation:Validation for each matrix Occurrence study:Investigate co-occurrence in BelgiumFuture perspectives:Risk assessmentA SURVEY OF CITRININ AND OCHRATOXIN A IN FOOD AND FEED IN BELGIUMC. MEERPOEL1,2, A. VIDAL1, Y. BAS1, B. HUYBRECHTS3, E. TANGNI3, M. DEVREESE2, S. CROUBELS2 AND S. DE SAEGER1Contactceline.meerpoel@ugent.bewww.ugent.be/fw/bioanalysis/en/research/foodanalUniversiteit Gent@ugentGhent UniversityLIVESTOCK EXPOSED TO TOXINSRISK FOR ANIMAL HEALTHOCHRATOXIN A (OTA)Method development: Analysis of CIT and OTA in Belgian food and feedEvaporation of 1 mL of upper layerMatrix Total (n)CIT OTAPositives(n)Range (µg/kg)Positives(n)Range (µg/kg)Cereals 31 13 <LOQ-1.00 18 <LOQ-0.37Fruit- and vegetable juices, raisins20 3 <LOQ-0.16 8 <LOQ-11.30Alcoholic drinks 8 0 <LOQ 3 <LOQNuts and seeds 22 3 <LOQ-0.21 6 <LOQ-0.81Soy and vegetarian products 8 2 <LOQ-1.55 2 <LOQ-0.23Baby food 10 2 <LOQ-0.21 2 <LOQMeat 6 2 <LOQ-0.23 3 <LOQFood supplements 12 2 <LOQ-2,073.62 0 <LOQOlives 2 0 <LOQ 0 <LOQCheese 3 1 <LOQ 0 <LOQHerbs and spices 24 15 <LOQ-4.49 4 <LOQ-2.73Feed 90 44 < LOQ-3.90 71 <LOQ-5.60CIT contamination not regulated*: maximum allowed concentration?IntroductionFUNGI DURING STORAGE AGRICULTURAL CROPS TOXINS IN FOOD RISK FOR PUBLIC HEALTHCITRININ (CIT)CITRIRISK PROJECT:Sources of CIT?Toxicity, Toxicokinetics?Risks?Validation followingCommission Regulation No. 401/2006/ECCommission Decision No. 2002/657/ECSpecificityLinearityApparentrecoveryLOD LOQMeasurementuncertaintyMatrixeffectsExtractionefficienyPrecisionTable 1: Results of CIT/OTA analysis in a variety of Belgian food and feed samplesFoodCereals, herbs and spices are the major source of CIT. One food supplement containing red yeast rice (RYR) was highly contaminated with CIT in a concentration above the legal limit of 2 mg/kg.FeedA high percentage (> 50%) of feed samples were contaminated.Co-occurrenceCIT and OTA co-occur in Belgium, especially in cereals and feed.Highlights occurrence study (Table 1)Link with nephrotoxicity: public health hazard?*Except for RYR: 2 mg/kgUse of results• Selection of a higher number of samples of the main contaminated food groups.• Investigate risk of contaminated feed for animal health.• Performance of a risk assessment by using occurrence and toxicokinetic data: exposure assessment and risk characterization for both Belgian population and pig  andpoultry sector.UncertaintiesLivestock is exposed: carry-over to edible tissue?1 Department of Bioanalysis, Centre of Excellence in Mycotoxicology and Public Health, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium2 Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium3 Chemical and Physical Health Risks, Organic Contaminants and Additives, Sciensano, Tervuren, Belgium* Corresponding author: Celine.Meerpoel@UGent.beMaterial and methods ResultsResults ConclusionsCIT and OTA are frequently detected in food and feed from the Belgian market. 10 mL acidified H2O20 mL organic extraction solvent (ACN)QuEChERS salts4 g of sample1 h extractionSalting outReconstituted sampleLC-MS/MS analysisFOOD FEEDMatrices Sample prep*N = 90March – June 2017Chicken (broiler) and pigN = 146February – April 2018Variety of foodgroups(Figure 1 and Table 1)Fig. 1: Presentation of selected food groups for CIT and OTA analysisThis research was funded by theBelgian Federal Public Service ofHealth, Food Chain Safety andEnvironment through the contractRT 16/6308 CITRIRISK.Acknowledgements*Small modifications per matrix

A survey of citrinin and ochratoxin A in food and feed in Belgium

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A survey of citrinin and ochratoxin A in food and feed in Belgium

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