<div><p>ABSTRACT: Fayoum region is the most fertile agricultural land in Egypt and one of the oldest agricultural city in the world. The present study aimed to determine its weed flora composition and its distribution through different habitats. Results recorded 175 species of vascular plants belonging to 124 genera and 35 families distributed in eight habitats. The richest families were Poaceae, Asteraceae (Compositae) and Fabaceae (Leguminoseae), while genera with the highest number of species were Euphorbia, Amaranthus and Cyperus. Cynodon dactylon and Alhagi graecorum were the present species, recorded at all habitats. Old cultivated lands recorded the highest species number followed by orchard habitats, on the contrast road side and wasteland habitats recorded the lowest species numbers. Therophytes were the dominant life form, while Phanerophytes were the smallest group in this study, 5%. The highest Jaccard similarity index was recorded between healthy land and orchard habitats, which supported also by ward classification.</p></div