Figure S5. Localization of phosphotau immunoreactivity versus G85R-SOD1:YFP pathology in bigenic JNPL3-G85R-SOD1:YFP mice. Hyperphosphorylated human tau pathology recognized by the AT8 (Ser202/Thr205) antibody appears similar in JNPL3 single transgenic versus JNPL3- 85R-SOD1:YFP bigenic mice (a, b). G85R-SOD1:YFP pathology, detected by an YFP antibody (c), does not robustly co-localize with tau pathology in double transgenic mice (d). Nuclei were stained with DAPI (blue). Images are of 60× magnification within the ventral horn of the spinal cord of JNPL3 and JNPL3-G85R-SOD1:YFP mice. (TIF 869 kb
