Biomacromolecule
loading is the popular research in the biomedical
field. To control the loading amount and releasing profile, various
materials and fabrication techniques were developed. In this study,
layer-by-layer assembly of multilayer films between collagen (Col)
and graphene oxide (GO) was used to control the release of the loading
molecule. By mixing GO into the system, ovalbumin (OVA) can be spontaneously
adsorbed onto the GO sheet (denoted as GO/OVA) via the hydrophobic
interaction. Two kinds of multilayer films (Col/GO/OVA and Col/GO/OVA)
were fabricated. The thickness growth curve, quantitative of each
layer adsorption, film morphology, stability, cell viability, and
OVA release from multilayer films were investigated. The result has
shown excellent film stability, macromolecule loading, and sustained
release because of GO ability
