Figure S5. Proteomic subgroup classification recapitulates genomic subgroups using different data elements. Comparison of non-negative matrix factorization consensus clustering between protein and mRNA expression data from 34 primary medulloblastoma and five normal cerebellar tissues. a) The Cophenetic and Silhouette coefficient values for rank k between 2 and 10 in mRNA and protein dataset. b) NMF clusters (kâ=â6) for the same genes coding for the proteins used in the proteomic classification at the mRNA or protein level. Clustering did not improve for other k values 2 through 10 (data not shown). (PDF 994 kb
