Additional file 3: of Immunomodulatory activities of pixatimod: emerging nonclinical and clinical data, and its potential utility in combination with PD-1 inhibitors
The incidence and severity of noteworthy microscopic findings in kidneys, liver, spleen and thymus. Perivascular mixed cell infiltrate was present in most mid- and high-dose individuals. Minimal to mild dilatation of renal tubules was apparent in most treated individuals though minimal or mild glomerular vacuolation or sclerosis was only reported in high-dose individuals. Minimal to mild hepatocellular hypertrophy was evident across dose levels whereas incidence and severity of hypertrophy of Kupffer cells in the liver was dose-dependent. A minimal to mild increase in cell infiltrate was apparent some high-dose individuals. There was also evidence of diffuse mixed cellular infiltrate in the spleen and minimal to mild lymphoid atrophy of the thymus observed in mid and high dose animals. (DOCX 13 kb
