Additional file 1: of Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivo
Supplementary text: description of measurement and outcome of guinea pig food consumption. Figure S1. (a) MACH-1 mechanical testing system. (b) View of a guinea pig femoral condyle with a position grid superimposed; Figure S2. Body weight of guinea pigs during the study. Figure S3. Partial least squares (PLS) regression model of serum glycated, oxidized, and nitrated amino acids Hyp and CP on total OA histological score. Table S1. Serum glycated, oxidized, nitrated, and citrullinated protein in the guinea pig model of osteoarthritis; Table S2. Correlation between glycation, oxidation, and nitration free adducts and hydroxyproline. Table S3. Correlations between glycated, oxidized, nitrated, and citrullinated serum protein. Table S4. Confusion matrix and nCorrect. (DOCX 735 kb
