Figures S1-S2. Depiction of surrogate variable selection process for SEED (S1) and SSC (S2). Panel A: Heatmap indicating degree of association with known potential technical variables or confounders with estimated surrogate variables. Panel B: Inflation factor (lambda) calculated for progressively including surrogate variables in association models. The number of surrogate variables to include in the ultimate association testing model was to determine to be that which properly controlled the inflation factor and adequately captured known technical variables or confounders. See âMethodsâ for additional explanation. (PDF 19Â kb
