Figure S1. Bioinformatic method comparison for gene expression analysis of C9ORF72-associated ALS and sporadic ALS (sALS) in the frontal cortex and cerebellum. (a-d) Gene density plots comparing the expression levels of differentially expressed transcripts as determined by the prior double cut-off method (|log2 fold change| ≥ 2 and p-value < 0.05) and the FDR method (FDR < 0.05), which was used in Fig. 1 and subsequent analysis. Note, no significant changes were detected in the sALS cerebellum using with FDR method. (e) Venn diagrams demonstrating considerable differences in the designated disease-associated transcripts between these bioinformatics methods in both brain regions. (f) Table of the number of differentially expressed transcripts as determined by Prudencio et al., the double cut-off method and the FDR method used here. (PDF 216 kb
