Additional file 2. Subject-related deviation scores per cortical spot for the right hemisphere Results for stimulation of the right hemisphere. Deviation scores of subject 1–10. Number of subjects with negative deviation scores (“leftward”) and mean of their scores. Number of subjects with positive deviation scores (“rightward”) and mean of their scores. Outline per cortical spot (no. 1–52) plus mean, standard deviation (SD), minimum (MIN), and maximum (MAX)

Bernhard Meyer (281955)

Claus Zimmer (732927)

Katrin Giglhuber (5506562)

Sandro Krieg (5506565)

Stefanie Maurer (732926)

Additional file 4. Raw data per cortical spot for the right hemisphere. Results for stimulation of the right hemisphere. Raw data of each subject. Number of effective stimulations, “leftward” answers and “rightward” answers. Outline per cortical spot (no. 1–52) plus mean, standard deviation (SD), minimum (MIN), and maximum (MAX)

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Abstract Background Visuospatial attention is executed by the frontoparietal cortical areas of the brain. Damage to these areas can result in visual neglect. We therefore aimed to assess a combination of the greyscales task and repetitive navigated transcranial magnetic stimulation (rTMS) to identify cortical regions involved in visuospatial attention processes. This pilot study was designed to evaluate an approach in a cohort of healthy volunteers, with the future aim of using this technique to map brain tumor patients before surgery. Ten healthy, right-handed subjects underwent rTMS mapping of 52 cortical spots in both hemispheres. The greyscales task was presented tachistoscopically and was time-locked to rTMS pulses. The task pictures showed pairs of horizontal rectangles shaded continuously from black at one end to white at the other, mirror-reversed. On each picture the subject was asked to report which of the two greyscales appeared darker overall. The responses were categorized into “leftward” and “rightward,” depending on whether the subject had chosen the rectangle with the darker end on the left or the right. rTMS applied to cortical areas involved in visuospatial attention is supposed to affect lateral shifts in spatial bias. These shifts result in an altered performance on the greyscales task compared to the baseline performance without rTMS stimulation. Results In baseline conditions, 9/10 subjects showed classic pseudoneglect to the left. Leftward effects also occurred more often in mapping conditions. Yet, calculated rightward deviations were strikingly greater in magnitude (p < 0.0001). Overall, the right hemisphere was found to be more suggestible than the left hemisphere. Both rightward and leftward deviation scores were higher for the rTMS of this brain side (p < 0.0001). Right hemispheric distributions accord well with current models of visuospatial attention (Corbetta et al. Nat Neurosci 8(11):1603–1610, 2005). We observed leftward deviations triggered by rTMS within superior frontal and posterior parietal areas and rightward deviations within inferior frontal areas and the temporoparietal junction (TPJ). Conclusion The greyscales task, in combination with rTMS, yields encouraging results in the examination of the visuospatial attention function. Future clinical implications should be evaluated

Katrin Giglhuber

Stefanie Maurer

Claus Zimmer

Bernhard Meyer

Sandro M. Krieg

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BMC Neuroscience

Mapping visuospatial attention: the greyscales task in combination with repetitive navigated transcranial magnetic stimulation

Botha, Henk

Schaks, Nils

Steiger, Dominik

Mannheim Electronic DOCument Server der Universitätsbibliothek Mannheim