Figure S3. Examples of relationships between the acoustic startle response and prepulse inhibition in mutant and wild-type mice. (A–C) Scatter plots of acoustic startle amplitudes and percentages of prepulse inhibition in mutant strains of mice with a C57BL/6 background (for Apc1638T/1638T mice, Onouchi et al., 2014; for Gria4−/− mice, Sagata et al., 2010; for Zfhx2−/− mice, Komine et al., 2012) that were obtained from the Mouse Phenotype Database ( http://www.mouse-phenotype.org ) show that the interpretation of differences in PPI levels between mutant and wild-type mice may be confounded by differences in basal startle reactivity (refer to Discussion and Fig. 4). The scatter plots suggest that differences in PPI levels between Apc1638T/1638T and Apc+/+ mice and between Gria4−/− and Gria4+/+ mice may result from low startle reactivity in mutants (A, B), and the lower levels of PPI in Zfhx2−/− may be a result of their higher startle reactivity (C). (PDF 472 kb
