<p>(A) Schematic representation of core subunit composition of F-type ATP synthase. The different subunits are color coded and annotated. Middle, the complete set of subunits of the core enzyme; left and right, subunits identified and not identified by in silico methods in apicomplexan genome. (B) Table showing the presence/absence of orthologs of yeast and bovine F-type ATP synthase in <i>Apicomplexa</i> and other alveolate species. +/−, presence/absence of ortholog; blue, diverged (no clear orthologs) functional equivalent; light blue, experimentally identified species-specific novel subunits (numeric values indicate the total number of such novel subunits). Species names: <i>Pfal</i>, <i>P</i>. <i>falciparum</i>; <i>Pviv</i>, <i>Plasmodium vivax</i>; <i>Tpar</i>, <i>Theileria parva</i>; <i>Bbov</i>, <i>Babesia bovis</i>; <i>Tgon</i>, <i>T</i>. <i>gondii</i>; <i>Ncan</i>, <i>Neospora caninum</i>; <i>Cmur</i>, <i>Cryptosporidium muris</i>; <i>Cpar</i>, <i>Cryptosporidium parvum</i>; <i>Chom</i>, <i>Cryptosporidium hominis</i>; <i>Cvel</i>, <i>Chromera velia</i>; <i>Pmar</i>, <i>Perkinsus marinus</i>; <i>Tthe</i>, <i>T</i>. <i>thermophila</i>; <i>Scer</i>, <i>Saccharomyces cerevisiae</i>; <i>Btau</i>, <i>Bos taurus</i>; <i>Atha</i>, <i>Arabidopsis thaliana</i>; <i>Crei</i>, <i>Chlamydomonas reinhardtii</i>; <i>Tbru</i>, <i>T</i>. <i>brucei</i>. IF1, inhibitory factor 1; OSCP, oligomycin sensitivity–conferring protein.</p
