Synthesis and anticancer activity of some novel diethyl {(chromonyl/pyrazolyl) [(4-oxo-2-phenyl-quinazolin-3(4<i>H</i>)-yl)amino]methyl}phosphonates

Abstract

<p>The synthesis of some novel chromonyl and pyrazolyl α-aminophosphonates containing a quinazolinone ring was carried out by applying <i>Pudovik</i> and <i>Kabachnik</i>-<i>Fields</i> reactions under solvent- and catalyst-free conditions. The anticancer activities of these compounds were evaluated against five cancer cell lines. 3-{[(3-Phenyl/1,3-diphenyl-1<i>H</i>-pyrazol-4-yl)methylidene]amino}-2-phenyl-quinazolin-4(3<i>H</i>)-ones (<b>3d,e</b>) and diethyl {[3-phenyl/1,3-diphenyl-1<i>H</i>-pyrazol-4-yl][(4-oxo-2-phenyl-quinazolin-3(4<i>H</i>) yl)amino] methyl}phosphonates (<b>4d,e</b>) displayed the potent anticancer activities against HCT116, MCF-7 and HepG2 cell lines in comparison with the standard drug.</p