Branch-Selective and Enantioselective Iridium-Catalyzed Alkene Hydroarylation via Anilide-Directed C–H Oxidative Addition

Abstract

Tertiary benzylic stereocenters are accessed in high enantioselectivity by Ir-catalyzed branch selective addition of anilide <i>ortho</i>-C–H bonds across styrenes and α-olefins. Mechanistic studies indicate that the stereocenter generating step is reversible