Table S1: Distribution of clinico-pathological variables between patients with sufficient tumor material for biomarker analysis and the total group of patients who entered the study patients with sufficient tumor material. Table S2: Inter-observer variability for Ki67 and cyclin D1 immunohistochemistry scores antibody scoring system comparable cores. Table S3: Specifications of REMARK recommendations. Table S4: Multivariate Cox proportional hazard model of recurrence free interval (RFI) including mitotic count and treatment interaction, follow up truncated at 6Â years. Table S5: Multivariate Cox proportional hazard model of recurrence free interval (RFI) including mitotic count and treatment interaction, follow up truncated at 6Â years in HER2 negative patients. Table S6: Multivariate Cox proportional hazard model of recurrence free interval (RFI) including CCND1 copy number ratio and treatment interaction. Table S7a: Interaction tests between tamoxifen and EMSY probe sets analyzed as continuous. Table S7b: Interaction tests between tamoxifen and EMSY probe sets analyzed as binary factor. (PDF 368 kb
