Voice recording during a sustained vowel /a/ before stromal vascular fraction injection: hoarse, unstable, and slightly breathy voice. (WAV 1880 kb

Alexia Mattei (5567189)

Antoine Giovanni (5567213)

Baptiste Bertrand (5567195)

Fanny Grimaud (5567198)

Florence Sabatier (341187)

Joana Revis (5567201)

Julie Veran (5567207)

Jérémy Magalon (3848548)

Mélanie Velier (5567225)

Patrick Dessi (5567210)

Stem Cell Research & Therapy

International audiencePatients with scarred vocal folds (congenitally or following phonosurgery) are currently difficult to treat and present a dysphonia, often disabling in daily life. Several therapies are available on the market but the results of these are often disappointing. The autologous adipose-derived stromal vascular fraction (ADSVF) is recognized as an easily accessible source of cells with angiogenic, anti-inflammatory, immunomodulatory, and regenerative properties. We present here the case of a 43-year-old woman who had a severe dysphonia associated with scarred vocal folds after a phonosurgery and was resistant to conventional medical and surgical treatments. She received a local administration of autologous ADSVF. The protocol involved, on the same day, adipose tissue extraction, ADSVF preparation, and then local injection (0.45ml of ADSVF in each vocal fold, for a total of 12.2 million ADSVF viable cells). No serious adverse events have been described. One year following the surgery, the laryngoscopic aspect and the majority of voice parameters had improved, in particular the Voice Handicap Index decreasing from 75 to 9. The perceptual analysis found the voice to be less hoarse and more stable, without breathiness. The case of this patient highlights the therapeutic potential of ADSVF for such applications (trial registration, ClinicalTrials.gov NCT02622464; registered 4 December 2015)

Mattei, Alexia

Magalon, Jeremy

Bertrand, Baptiste

Grimaud, Fanny

Révis, Joana

Velier, Melanie

Veran, Julie

Dessi, Patrick

Sabatier, Florence

Giovanni, Antoine

Archive Ouverte en Sciences de l'Information et de la Communication

Autologous adipose-derived stromal vascular fraction and scarred vocal folds: first clinical case report

Abstract Patients with scarred vocal folds (congenitally or following phonosurgery) are currently difficult to treat and present a dysphonia, often disabling in daily life. Several therapies are available on the market but the results of these are often disappointing. The autologous adipose-derived stromal vascular fraction (ADSVF) is recognized as an easily accessible source of cells with angiogenic, anti-inflammatory, immunomodulatory, and regenerative properties. We present here the case of a 43-year-old woman who had a severe dysphonia associated with scarred vocal folds after a phonosurgery and was resistant to conventional medical and surgical treatments. She received a local administration of autologous ADSVF. The protocol involved, on the same day, adipose tissue extraction, ADSVF preparation, and then local injection (0.45ml of ADSVF in each vocal fold, for a total of 12.2 million ADSVF viable cells). No serious adverse events have been described. One year following the surgery, the laryngoscopic aspect and the majority of voice parameters had improved, in particular the Voice Handicap Index decreasing from 75 to 9. The perceptual analysis found the voice to be less hoarse and more stable, without breathiness. The case of this patient highlights the therapeutic potential of ADSVF for such applications (trial registration, ClinicalTrials.gov NCT02622464; registered 4 December 2015)

Alexia Mattei

Jérémy Magalon

Baptiste Bertrand

Fanny Grimaud

Joana Revis

Mélanie Velier

Julie Veran

Patrick Dessi

Florence Sabatier

Antoine Giovanni

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