Additional file 2: Fig. S2. Locomotor activity of AppNL-G-F/NL-G-F and AppNL/NL mice during the first and second trials in the elevated plus maze task. The distance travelled during the 10-min test of the first and second trials in the elevated plus maze task was compared among genotypes at both 6–9 (a–d) and 15–18 (e–h) months of age. Representative images of movement tracks during the first and second trials for each genotype at 6–9 (a and c) and 15–18 (e and g) months of age were shown (closed arms are indicated by shaded areas). At 6–9 months of age, AppNL-G-F/NL-G-F mice exhibited slight increases in distance travelled during the first (b) and second (d) trials in comparison with WT mice. By contrast, locomotor activity in AppNL/NL mice was comparable with WT mice in the two trials. At 15–18 months of age, AppNL-G-F/NL-G-F mice exhibited a slight increase in movement compared to WT mice during the first (f) and second (g) trials. AppNL/NL mice moved at similar levels compared with WT mice in the two trials. 6–9 month-old; n = 8 WT (B6J), n = 8 AppNL/NL, n = 8 AppNL-G-F/NL-G-F. 15–18 month-old; n = 12 WT (B6J), n = 10 AppNL/NL, n = 11 AppNL-G-F/NL-G-F. †p < 0.05 versus AppNL/NL
