An
efficient and practical strategy for the synthesis of β-aminoenones
from a three-component reaction was developed. Ethyl bromodifluoroacetate
serves as a C1 source in this strategy, forming isocyanides in situ
with primary amines. This reaction represents the first example of
utilization of readily available starting materials to generate isocyanides
in situ and sequentially fully converted to β-aminoenones, avoiding
the generation of byproduct imines and overinsertion products. The
mechanism study suggested that this method involves activation of
two C(sp<sup>3</sup>)–F bonds and the formation of isocyanides,
which might nourish both isocyanide chemistry and fluorine chemistry
