Background: Aggressive periodontitis disease is a severe type of periodontal disease, which is characterized by enormous destruction of periodontal attachment and alveolar bone. A few loci have shown to be associated with aggressive periodontitis, which suggest a multifactorial genetic component. BRINP3 locus shows correlation with aggressive periodontitis.
Aims: To replicate the initial findings of the relationship between aggressive periodontitis and BRINP3 genetic variation (rs1342913) in group of Arab subjects.
Methods: 263 subjects were diagnosed with aggressive periodontitis. They are originally from Syria and Morocco. They are divided into: diseased (with aggressive periodontitis n= 200. Among them 49 from Syria and 151 from Morocco). and healthy (without aggressive periodontitis n= 63). Saliva was collected, then genomic DNA was extracted. One genetic marker was genotyped (BRINP3 rs1342913). PCR was run with TaqMan chemistry. Chi-square with alpha of 0.05 was utilized to test over-representation of genotypes or alleles between two groups.
Result: The frequency AA genotype is higher than GG genotype. No significant difference between allele A and allele G.
Conclusion: The frequency BRINP3 is higher in aggressive periodontitis compared with healthy cases in Arab population. Based on this result, BRINP3 gene is associated with aggressive periodontists
