Author Institution (Bray): Department of Human Nutrition and Food Management, The Ohio State University; Author Institution (Wittum): Department of Veterinary Preventative Medicine, The Ohio State Universit

Bray, Tammy

Morley, Paul

Wittum, Thomas

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OARDC Research EnhancementCompetitive Grants ProgramNumber 9Effects of Vitamin E and Aspirin on Disease in CattleTammy Bray, Human Nutrition and Food ManagementPaul Morley and Thomas Wittum, Veterinary Preventive Medicine The Bovine Respiratory Disease Complex, or “shipping fever,” causes approximately $600 million in annual losses to the North American beef cattle industry. This potentially deadly disease is caused by viral and bacterial infections of the respiratory tract.  Despite considerable effort, no generally effective prevention or control measures have been identified for this disease. Because vaccinations and antibiotic treatments are only moderately successful, alternative approaches need to be identified. This research was funded through the OARDC Research Enhancement Competitive Grants Program, which receives funding from dollars appropriated by the state of Ohio.October 2001 RECGP FS9College ofBiological SciencesC H A L L E N G E SShipping fever is a costly and widespread problem for the cattle industry. Current treat-ments, including vaccines and antibiotics, are not totally effective for controlling shipping fever. It is necessary to identify alternative treatments to decrease the devastating losses incurred by the beef cattle industry.A C H I E V E M E N T SFrom this study, OARDC researchers found that treatment with aspirin and Vitamin E may decrease the toxic effects of 3-MI and reduce the susceptibility to respiratory viruses and shipping fever.T H E  F U T U R EResults from this initial study were presented in two papers published in the American Journal of Veterinary Research. Additional funding in the amount of $205,000 has been obtained to further characterize the role of 3-MI in the Bovine Respiratory Disease Complex.A naturally occurring chemical 3-Methylindole (3-MI) found in cattle increases with dietary changes and stress.  Results of this research show that the increase of 3-MI during times of stress combined with exposure to non-fatal Bovine Respiratory Syncytial Virus (BRSV) resulted in a higher incidence of shipping fever.  Thus, controlling the combined exposure may be an important step in preventing respiratory disease in feedlot cattle and reducing losses associated with the disease.Aspirin has been shown to decrease the severity of lesions in the lungs caused by 3-MI because aspirin decreases the natural conversion of 3-MI to its toxic product. Vitamin E, acting as an antioxidant, can decrease the toxicity of any products produced from 3-MI. Thus, the OARDC-funded researchers ex-amined the combination of aspirin and Vitamin E as a possible treatment regimen to prevent respiratory disease.

Effects of Vitamin E and Aspirin on Disease in Cattle

https://kb.osu.edu/bitstream/1811/49811/1/OARDC_SEEDS_No-9_Vit_E_and_Aspirin_on_Cattle_Disease.pdf

Effects of Vitamin E and Aspirin on Disease in Cattle

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