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research
Determination of Dipyrone in pharmaceutical preparations based on the chemiluminescent reaction of the quinolinic hydrazide-H2O2-vanadium (IV) system and flow injection analysis
Authors
Jesús Senén Durand Alegría
Pilar Fernández Hernando
Adolfo Narros Sierra
Juan Angel Pradana Pérez
Publication date
1 January 2011
Publisher
'Wiley'
Doi
Abstract
A rapid, economic and sensitive chemiluminescent method involving flow-injection analysis was developed for the determination of dipyrone in pharmaceutical preparations. The method is based on the chemiluminescent reaction between quinolinic hydrazide and hydrogen peroxide in a strongly alkaline medium, in which vanadium(IV) acts as a catalyst. Principal chemical and physical variables involved in the flow-injection system were optimized using a modified simplex method. The variations in the quantum yield observed when dipyrone was present in the reaction medium were used to determine the concentration of this compound. The proposed method requires no preconcentration steps and reliably quantifies dipyrone over the linear range 1–50 µg/mL. In addition, a sample throughput of 85 samples/h is possible. Copyright © 2011 John Wiley & Sons, Ltd
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oai:oa.upm.es:12275
Last time updated on 17/07/2013
Servicio de Coordinación de Bibliotecas de la Universidad Politécnica de Madrid
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oai:oa.upm.es:12275
Last time updated on 10/02/2018