Protective effects of Cinnamon hydro-alcoholic extract on liver lesions induced non-alcoholic fatty liver disease and sodium nitrite poisoning in adult male rats
Background and aims: Cinnamon by reducing the oxidative stress level causes improving the oxidative attributes. Fatty liver disorder and the use of food preservatives such as sodium nitrite as well as fatty liver disease cause liver disorders and relevant diseases around the world. Therefore, this study was aimed to investigate the effects of cinnamon extract on histological changes induced by high-fat diet and sodium nitrite in adult male rats.
Methods: In this experimental study, 80 adult male rats were used. The adult rats are divided in control group (un treated), sham (treated with solvent), 7 experimental groups receiving high-fat diet(10ml/kg), cinnamon extract (60mg/kg), sodium nitrite (45mg/kg), cinnamon with sodium nitrite, cinnamon with high-fat diet, sodium nitrite with high-fat diet, high-fat diets with sodium nitrite and cinnamon were performed. The prescriptions have been done through gavage in 60 days. At the end, after anesthetizing rats, their livers were seperated and after preparing tissue sections, liver cells were counted. The obtained results of tissue studies and cell counting have been analyzed using SPSS software through ANOVA and Duncan tests. In this study, data difference was significant (P<0.05).
Results: The results showed a significant increase and decrease in the groups receiving high-fat diet and sodium nitrite, respectivly in Kupffer cells numbers and Hepatocytes (P<0.01). It was also observed changes such as Hyperemia, coagulation necrosis, cell swelling, vacuoles erosion, lymphocytic infiltration, apoptosis, hyperemia, ballooning hepatocytes in liver tissue structure. So, changes in the groups receiving cinnamon with high-fat diet and sodium nitrite modified.
Conclusion: High-fat diets and sodium nitrite likely causes liver tissue damage by oxidative stress. Cinnamon extract may also with strong antioxidant properties prevent sodium nitrite destructive effects and high-fat diet on liver tissue
