Breast cancer is one of the leading causes to women mortality in the world and early detection is an important means to reduce the mortality rate. The presence of microcalcifications clusters has been considered as a very important indicator of malignant types of breast cancer and its detection is important to prevent and treat the disease. This paper presents an alternative and effective approach in order to detect microcalcifications clusters in digitized mammograms based on the synergy of the image processing, pattern recognition and artificial intelligence. The mathematical morphology is an image processing technique used for the purpose of image enhancement. A k-means algorithm is used to cluster the data based on the features vectors and finally an artificial neural network-based classifier is applied and the classification performance is evaluated by a ROC curve. Experimental results indicate that the percentage of correct classification was 99.72%, obtaining 100% true positive (sensitivity) and 99.67% false positive (specificity), with the best classifier proposed. In case of the best classifier, we obtained a performance evaluation of classification of Az = 0.987
