久保山 友晴

李 英娥

東田 千尋

松永 智子

University of Toyama Repository

⚄⤒ᶵ⬟Ꮫศ㔝 Division of Neuromedical Science෸ᩍᤵ ᮾ⏣ ༓ᑜ Associate Professor Chihiro Tohda (Ph.D.)ຓ ᩍ ஂಖᒣ཭ᬕ Assistant Professor Tomoharu Kuboyama (Ph.D.)◊✲ဨ ᯇỌ ᬛᏊ (9᭶ࡲ࡛) Postdoctoral Fellow Satoko Matsunaga (Ph.D.)◊✲ဨ ᮤ  ⱥ ፑ(10᭶ࡼࡾ) Postdoctoral Fellow Young-A Lee (Ph.D.)㻌ۍ◊✲┠ⓗ㻌㻌 ᮏศ㔝࡛ࡣ㸪⚄⤒ᅇ㊰⥙ࡀ◚⥢ࡍࡿࡇ࡜࡟ࡼࡗ࡚ᶵ⬟୙඲ࡀ㐍⾜࠶ࡿ࠸ࡣỌ⥆ࡍࡿ㞴἞ᛶ⚄⤒ኚᛶ⑌ᝈ㸦୺࡜ࡋ࡚࢔ࣝࢶࣁ࢖࣐࣮⑓㸪⬨㧊ᦆയ㸧ࢆࢱ࣮ࢤࢵࢺ࡜ࡋ࡚◊✲ࢆ⾜ࡗ࡚࠸ࡿࠋ⚄⤒ᅇ㊰⥙◚⥢ࡢ࣓࢝ࢽࢬ࣒࡜㸪ࡑࢀࢆᨵၿࡉࡏࡿࢫࢺࣛࢸࢪ࣮ࡢ㘽࡜࡞ࡿ⏕యࡢศᏊ࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡍࡿࡇ࡜࡛㸪⚄⤒ᅇ㊰⥙ࡀ◚⥢ࡋࡓᚋ࠿ࡽ࡛ࡶࡇࢀࡽ⑌ᝈ࡟࠾ࡅࡿ⚄⤒ᶵ⬟ࢆṇᖖ࡟ᅇ᚟ࡉࡏࡿࡼ࠺࡞㸪᰿ᮏⓗ἞⒪ᡓ␎࡜ࡋ࡚ࡢ͆⚄⤒ᅇ㊰⥙෌ᵓ⠏⸆͇ࡢ㛤Ⓨࢆ┠ᣦࡋ࡚࠸ࡿࠋ࢔ࣝࢶࣁ࢖࣐࣮⑓◊✲࡛ࡣ㸪ࣔࢹ࣐ࣝ࢘ࢫࡢグ᠈㞀ᐖࢆ㢧ⴭ࡟ᨵၿࡍࡿ₎᪉᪉๣ࡸ⏕⸆⏤᮶ᡂศࢆぢฟࡋ࡚࠸ࡿࠋ⬨㧊ᦆയ◊✲࡟࠾࠸࡚ࡶ㸪ࣔࢹ࣐ࣝ࢘ࢫࡢ㐠ືᶵ⬟㞀ᐖࢆ㢧ⴭ࡟ᨵၿࡍࡿ⸆≀ࢆ㸪ఏ⤫⸆≀ࡢゎᯒࢆࡶ࡜࡟Ⓨぢࡋ࡚ࡁࡓࠋࡲࡓ⌧ᅾ㸪ࡇࢀࡽఏ⤫⸆≀⏤᮶ࡢపศᏊ໬ྜ≀࡟ࡼࡿ᪂ࡓ࡞ࢩࢢࢼࣜࣥࢢࡢゎᯒࢆ㸪⚄⤒ᅇ㊰⥙෌ᵓ⠏ࡢ㘽ࢆᥱࡿศᏊࢆゎ᫂ࡍࡿどⅬ࡛㐍ࡵ࡚࠸ࡿࠋఏ⤫⸆≀⏤᮶ࡢ໬ྜ≀ࡸ㸪₎᪉᪉๣ࡢ㸪ከ㠃ⓗ࡛᪂ࡋ࠸స⏝ᶵᗎࡢゎ᫂࡟㸪ከᒙⓗ࣭ືⓗᐇ㦂ᡭἲ࡛㏕ࡗ࡚࠸ࡿࠋࡇࡢࡼ࠺࡟㸪ఏ⤫⸆≀◊✲࡜⚄⤒⛉Ꮫࢆ⼥ྜࡉࡏ㸪๰⸆࡜⑓ែゎᯒ࡬ᒎ㛤ࡉࡏࡿ⊂๰ⓗ࡛᭷┈࡞࢔ࣉ࣮ࣟࢳ࡜ࡋ࡚ࠕఏ⤫⸆≀-based ๰⸆ࠖࢆᥦ᱌ࡋᐇ㊶ࡋ࡚࠸ࡿࠋۍ◊✲ᴫせ㻌㻌 1) ୰ᯡ⚄⤒࡟࠾ࡅࡿ⚄⤒ࢿࢵࢺ࣮࣡ࢡ෌ᵓ⠏ࢆಁ㐍ࡍࡿศᏊᶵᗎࡢໟᣓⓗゎ᫂2) ఏ⤫⸆≀-based๰⸆࡟ࡼࡿ㸪࢔ࣝࢶࣁ࢖࣐࣮⑓࠾ࡼࡧ⬨㧊ᦆയ࡟ᑐࡍࡿ᰿ᮏⓗ἞⒪⸆ࡢ◊✲3) ࢔ࣝࢶࣁ࢖࣐࣮⑓࠾ࡼࡧ⬨㧊ᦆയ࡟࠾࠸࡚㍈⣴෌⏕୙඲࡜࡞ࡿศᏊᶵᗎࡢゎ᫂㻌 㻌ۍཎⴭㄽᩥ㻌㻌 1) Tohda C., Urano T., Umezaki M., Nemere I., Kuboyama T.: Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer’s disease pathologies in 5XFAD mice.Sci. Rep. 2, 535; DOI: 10.1038/srep00535, 2012.㻌 2) Tohda C., Nagata A.: Epimedium koreanum extract and its constituent icariin improve motor dysfunction in spinal cord injury. Evidence Based Complementary and Alternative Medicine2012:731208, 2012.㻌 3) Wang X.-H., Zhu H., Konno K., Tohda C., Kazuma K., Kuboyama T., Miyanaga S.: Screening of fractions from some Chinese herbs for spinal cord injury. Chinese Journal of Experimental Traditional Medical Formulae, 18(12):246-248, 2012.㻌 4) Sugimoto K., Tamura K., Ohta N., Tohda C., Toyooka N., Nemoto H., Matsuya Y.: Synthesis of dihydrofuran-fused perhydrophenanthrenes having a phenolic hydroxyl group as a novel anti-Alzheimer's disease agent. Bioorganic & Medicinal Chemistry Letters, 22(1):449-452, 2012.㻌⑓ែไᚚ㒊㛛㸫㸫―42―病態制御部門ۍᏛ఍ሗ࿌ 㸦≉ูㅮ₇㸪ࢩ࣏ࣥࢪ࣒࢘㸪࣮࣡ࢡࢩࣙࢵࣉ➼㸧 1) ᱵᔘ㞞ே㸪ᮡᮏెዉᏊ㸪᫓ᮌᏕஅ㸪ఀ⸨Ὀᆅ㸪Ṋ⏣‪㸪වᯇభ඾㸪ᮾ⏣༓ᑜ㸪໭ᖾᾏ㸪❧ᕝோ඾㸸㔞Ꮚ໬Ꮫⓗィ⟬࡟ࡼࡿேཧ⸆ຠᡂศ㸸Ginsenoside 㢮࡞࡝ࡢ⸆ຠᶵᵓࡢゎ᫂㸬᪥ᮏ⸆Ꮫ఍➨ 132ᖺ఍㸪2012, 3, 28-31㸪ᮐᖠ㸬㻖㻌 2) ஂಖᒣ཭ᬕ㸪Vance Lemmon㸪Jerry Silver㸪ᮾ⏣༓ᑜ㸪ୖཱྀ⿱அ㸸㜼ᐖᛶࣉࣟࢸ࢜ࢢࣜ࢝ࣥ࡟ࡼࡿ㍈⣴෌⏕㜼ᐖᶵᵓࡢゎ᫂㸬2012 ᖺᗘໟᣓ⬻ࢿࢵࢺ࣮࣡ࢡኟࡢ࣮࣡ࢡࢩࣙࢵࣉ㸪2012, 7, 24-27㸪௝ྎ㸬㻌 3) ᰘཎ┤฼㸪ᑠᯇ࠿ࡘᏊ㸪ᮒጨ㸪ᒣᮏṊ㸪㛛⬥┿㸪ᯇỌᬛᏊ㸪ᮾ⏣༓ᑜ㸪ᐑỌ㈼㸪ᩘ㤿ᜏᖹ㸪⤃㔝຾ᘯ㸸ࠕఏ⤫⸆≀ࢹ࣮ࢱ࣮࣋ࢫ ࡢࠖᵓ⠏㸦2㸧➨ 29ᅇ࿴₎་⸆Ꮫ఍Ꮫ⾡኱఍㸪2012, 9, 1-2㸪ᮾி㸬㻌 4) ᯇỌᬛᏊ㸪ᮾ⏣༓ᑜ㸪ⓑ↚ᬗ㸪ᮒጨ㸪ᑠᯇ࠿ࡘᏊ㸸࢔ࣝࢶࣁ࢖࣐࣮⑓ࣔࢹ࣐ࣝ࢘ࢫࢆ⏝࠸ࡓ Eleutheroside B࠾ࡼࡧ Eleutheroside Eࡢグ᠈ᨵၿຠᯝࡢ᳨ウ㸬➨ 29ᅇ࿴₎་⸆Ꮫ఍Ꮫ⾡኱఍㸪2012, 9, 1-2㸪ᮾி㸬㻖㻌 5) Tohda C.: Natural medicine study aiming to explore therapeutic strategies for neurodegenerative diseases. International Symposium on Biomedicine and Drug-Development. Nanotechnology: from Bench to Enduser. 2012, 9, 25, Basel.㻌 6) Shigyo M., Kuboyama T., Teshigawara K., Sugimoto K., Matsuya Y., Tohda C.: Denosomin improves SCI via axonal growth by increasing astrocyte-secreted vimentin. Neuroscience 2012, 2012, 10, 13-17, New Orleans㸬㻌 7) Tohda C., Urano T., Umezaki M., Nemere I., Kuboyama T.: Diosgenin is an exogenous activator of 1,25D3-MARRS (Pdia3/ERp57) and improves memory dysfunction and axonal degeneration in Alzheimer’s disease model 5XFAD mice. Neuroscience 2012, 2012, 10, 13-17, New Orleans㸬㻌 8) Kuboyama T., Teshigawara K., Shigyo M., Sugimoto K., Matsuya Y., Tohda C.: A novel compound, Denosomin induces vimentin-secretion from astrocytes, resulting in promotion of axon elongation. Neuroscience 2012, 2012, 10, 13-17, New Orleans㸬㻖㻌 9) ᮾ⏣༓ᑜ㸸Diosgenin࡟ࡼࡿ࢔ࣝࢶࣁ࢖࣐࣮⑓ࣔࢹ࣐ࣝ࢘ࢫࡢグ᠈ᨵၿస⏝࡜ࡑࡢศᏊ࣓࢝ࢽࢬ࣒㸬ᐩᒣ኱Ꮫ࿴₎་⸆Ꮫ⥲ྜ◊✲ᡤ࣭㛗ᓮ኱Ꮫ⇕ᖏ་Ꮫ◊✲ᡤ➨ 3 ᅇ஺ὶࢭ࣑ࢼ࣮㸪2012, 12, 20-21㸪㛗ᓮ㸬㻖㻌 10) ᮾ⏣༓ᑜ㸸ఏ⤫⸆≀ࢆ࣮࣋ࢫ࡜ࡋࡓ࢔࢝ࢹ࣑࢔๰⸆㸬➨ 3 ᅇ࿴₎◊࣭ࡀࢇ◊ࢪࣙ࢖ࣥࢺࢭ࣑ࢼ࣮ ࢔࢝ࢹ࣑࢔๰⸆ࡢᚰ࣭ᢏ࣭య㸪2013, 2, 14-15㸪㔠ἑ.㻌 11) ▮ᓥஂᡂ㸪ᮡᮏ೺ኈ㸪‖኱ᚿ㑻㸪ᮾ⏣༓ᑜ㸪ᯇ㇂⿱஧㸸᪂つ࢔ࣝࢶࣁ࢖࣐࣮἞⒪⸆๰〇ࢆ┠ᣦࡋࡓࢹࣀࢯ࣑ࣥ-VD3ࣁ࢖ࣈࣜࢵࢻࡢタィ࡜ྜᡂ㸬᪥ᮏ⸆Ꮫ఍➨ 133ᖺ఍㸪2013, 3, 27-30㸪ᶓ὾㸬㻌ᣍᚅㅮ₇㻖㻌 1) ᮾ⏣༓ᑜ㸸➨ 54ᅇ᪥ᮏ⸆Ꮫ఍➨ 132ᖺ఍ ≉ูࢩ࣏ࣥࢪ࣒࢘ ⸆Ꮫ⣔ዪᛶࡢ◊✲࢟ࣕࣜ࢔ᙧᡂ 㹼࢔࢝ࢹ࣑࢔࣭௻ᴗ࣭ୡ⏺ࢆ⯙ྎ࡟ 2012, 3, 31㸪ᮐᖠ㸬㻖㻌 2) Tohda C.: Natural medicine study aiming to explore therapeutic strategies for neurodegenerative diseases. 21st Symposium on Dementia. 2012, 4, 15, Seoul.㻖㻌 3) Tohda C., Kuboyama T., Teshigawara K., Shigyo M.: Novel mechanism of functional recovery from spinal cord injury. 14th International Congress of Histochemistry and Cytochemistry. 2012, 8, 26-29㸪ி㒔㸬㻖㻌 4) Kuboyama T.: A novel compound, denosomin ameliorates spinal cord injury via axonal growth associated with astrocyte secreted vimentin. 1st Jpoint symposium between Natural Products Research Institute, College of Pharmacy, Seoul National University and Institute of Natural Medicine, University of Toyama. 2012, 12, 15, Toyama.㻌㸫㸫―43―ۍࡑࡢ௚ࡑࡢ௚ࡢㅮ₇㻌 1) ᮾ⏣༓ᑜ㸸NPOἲேᐩᒣࡢࡃࡍࡋ➨ 10ᅇ₎᪉་Ꮫ࡜⏕⸆ㅮᗙࠕ⌧௦་⒪࡟࠾ࡅࡿ࿴₎⸆ࡢ᭷⏝ᛶ࡜ྍ⬟ᛶࠖ2012, 2, 25㸪ᐩᒣ㸬㻌 2) Tohda C.:ࠕDiosgenin studyࠖ Invited Seminar at Dong-A Pharm, 2012, 9, 10, Yongin.㻌 3) ᮾ⏣༓ᑜ㸸NPOἲேᐩᒣࡢࡃࡍࡋ➨ 11ᅇ₎᪉་Ꮫ࡜⏕⸆ㅮᗙࠕ⌧௦་⒪࡟࠾ࡅࡿ࿴₎⸆ࡢ᭷⏝ᛶ࡜ྍ⬟ᛶࠖ2013, 1, 19㸪ᐩᒣ㸬㻌 4) ᮾ⏣༓ᑜ㸸࢖ࣈࢽࣥࢢᢏ⾡஺ὶࢧࣟࣥࠕ࿴₎⸆◊✲࠿ࡽᣮࡴ㞴἞ᛶ⚄⤒⑌ᝈࡢ἞⒪⸆㛤Ⓨࠖ2013, 2, 1㸪ᐩᒣ㸬㻌ཷ㈹㻌㻌 1) ᯇỌᬛᏊ㸸➨ 29ᅇ࿴₎་⸆Ꮫ఍Ꮫ⾡኱఍ ඃ⚽Ⓨ⾲㈹㸬ࠕ࢔ࣝࢶࣁ࢖࣐࣮⑓ࣔࢹ࣐ࣝ࢘ࢫࢆ⏝࠸ࡓ Eleutheroside B࠾ࡼࡧ Eleutheroside Eࡢグ᠈ᨵၿຠᯝࡢ᳨ウ㸬ࠖ 2012, 9, 1-2㸪ᮾி㸬㻌᪂⪺࣭㞧ㄅ࣭ࢸࣞࣅ㻌 1) 䛂䜰䝹䝒䝝䜲䝬䞊⑓἞⒪䛻ග㻌 䝲䝬䜲䝰ᡂศ䛷グ᠈ᶵ⬟ᅇ᚟㻌 ᐩᒣ኱䜾䝹䞊䝥䝬䜴䝇䛷ຠᯝ☜ㄆ䛃ㆫ㈽᪂⪺㸪2012, 7, 27.㻌 2) 䛂䜰䝹䝒䝝䜲䝬䞊⑓㻌䝲䝬䜲䝰䛻ᨵၿᡂศ㻌ᮾ⏣ᐩᒣ኱෸ᩍᤵ䜙ᐇド㻌㐍⾜ᢚ䛘⬻ᶵ⬟ᅇ᚟໭᪥ᮏ᪂⪺㸪2012, 7, 27.㻌 3) 䛂䝲䝬䝜䜲䝰ᡂศグ᠈㞀ᐖ䜢ᨵၿ㻌 䜰䝹䝒䝝䜲䝬䞊⑓䛻ຠᯝ㻌 ᐩ኱࿴₎་⸆◊䜙Ⓨぢ䛃 ໭㝣୰᪥᪂⪺㸪2012, 7, 27.㻌 4) 䛂䝲䝬䜲䝰䛷グ᠈ຊᨵၿ㻌ᐩ኱࿴₎་⸆Ꮫ⥲ྜ◊䞉ᮾ⏣෸ᩍᤵ䜙㻌䜰䝹䝒䝝䜲䝬䞊⑓䛻ຠᯝ䛃 ᐩᒣ᪂⪺㸪2012, 7, 27.㻌 5) 䛂䜰䝹䝒䝝䜲䝬䞊⑓䛻䝲䝬䜲䝰ᡂศຠᯝ䛃໭ᾏ㐨᪂⪺㸪2012, 7, 27.㻌 6) 䛂䝲䝬䜲䝰䛾ᡂศ◊✲䛷᪂䛯䛺⚄⤒ఏ㐩⤒㊰Ⓨぢ㻌䜰䝹䝒䝝䜲䝬䞊⑓ᨵၿస⏝䛜䛃₎᪉་⸆᪂⪺㸪2012, 8, 1.㻌 7) 䛂䝲䝬䜲䝰ᡂศ䛷グ᠈ຊᨵၿ㻌 䜰䝹䝒䝝䜲䝬䞊⑓䛻ຠᯝ䛃᪥ᮏ⤒῭᪂⪺Webห㸪2012, 8, 5.㻌 8) 䛂⚄⤒෌⏕䛧⬨㧊ᦆയᨵၿ䛾ຠᯝ㻌ᐩᒣ኱䜾䝹䞊䝥䛜໬ྜ≀䛃ඹྠ㏻ಙ䝙䝳䞊䝇㸪2012, 11, 27.㻌 9) 䛂᪂໬ྜ≀䛷⚄⤒⣽⬊෌⏕㻌 ⬨㧊ᦆയ䜢ᨵၿ䛃໭ᅧ᪂⪺㸪2012, 11, 28.㻌 10) 䛂᪂໬ྜ≀䛷⚄⤒⣽⬊෌⏕㻌 ⬨㧊ᦆയ䜢ᨵၿ䛃ᐩᒣ᪂⪺㸪2012, 11, 28.㻌 11) 䛂⬨㧊ᦆയᨵၿ䛻ຠᯝ㻌ᐩᒣ኱࿴₎◊ᮾ⏣෸ᩍᤵ䜙㻌᪂໬ྜ≀䜢స〇䛃໭᪥ᮏ᪂⪺㸪2012, 11, 28.㻌 12) 䛂䝲䝬䜲䝰䛻䜰䝹䝒䝝䜲䝬䞊ᨵၿຠᯝ䛃 NHK඲ᅜ䝙䝳䞊䝇㸪2012, 7, 26.㻌 13) 䛂䝲䝬䜲䝰䛻䜰䝹䝒䝝䜲䝬䞊ᨵၿຠᯝ䛃 NHK䝙䝳䞊䝇ᐩᒣே㸪2012, 7, 26.㻌 14) 䝔䝺䝡ᮅ᪥ሗ㐨䝇䝔䞊䝅䝵䞁㸪2012, 7, 26.㻌 15) ᐩᒣ䝔䝺䝡 BBT䝇䞊䝟䞊䝙䝳䞊䝇㸪2012, 7, 26.㻌 16) ࢸࣞࣅᮅ᪥඲ᅜࢽ࣮ࣗࢫ㸪2012, 7, 26.㻌 17) ໭᪥ᮏᨺ㏦㻌 KNB News Every 䛂䝲䝬䜲䝰䛾ᡂศ䛜䜰䝹䝒䝝䜲䝬䞊⑓䜢ᨵၿ䛃㸪2012, 7, 26.㻌ۍඹྠ◊✲㻌㻌 1) ᑠᯇ࠿ࡘᏊ㸸ᐩᒣ኱Ꮫ㸪ࠕ⚄⤒ኚᛶ⑌ᝈ࡟᭷ຠ࡞ఏ⤫⸆≀ศᏊࡢ᥈⣴࡜ࡑࡢ἞⒪ᡓ␎ࠖ㻌 2㸧 ᯇ㇂⿱஧㸸ᐩᒣ኱Ꮫ㸪ࠕwithanolide㢮ࡢ◊✲ ࠖࠕ᪂つ໬ྜ≀ࡢ⚄⤒ಖㆤస⏝ࡢ◊✲ࠖ㻌 3) ᮾவ〇⸆㸦㡑ᅜ㸧㻌 4) ୖཱྀ⿱அ㸸⌮໬Ꮫ◊✲ᡤ㸪ࠕ㍈⣴෌⏕୙඲ࡢᶵᗎࢆゎ᫂ࡍࡿࡓࡵࡢ◊✲ࠖ㻌 5) ᱵᔘ㞞ே㸸ᐩᒣ኱Ꮫ㸪ࠕ⏕⸆ᡂศࡢ⸆ຠᶵᵓࡢゎ᫂ࠖ㸫㸫―44―㻌 6) ⤃㔝຾ᘯ㸸ᐩᒣ኱Ꮫ㸪ࠕᐩᒣ┴⏘࿴₎⸆࠿ࡽ㛤Ⓨࡍࡿ⬨㧊ᦆയᨵၿ⸆࡟㛵ࡍࡿ◊✲ࠖ㻌 7) ㇏ᒸᑦᶞ㸪᳃ᑑ㸪Ỉཱྀᓠஅ㸸ᐩᒣ኱Ꮫ㸪ࠕᵓ㐀άᛶ┦㛵࡟ᇶ࡙ࡃ⚄⤒ኚᛶ⑌ᝈ᪂つศᏊᶆⓗ἞⒪⸆ࡢ㛤ⓎᣐⅬᙧᡂࠖ㻌 8) ୖᒣ೺ᙪ㸸⚄ᡞ኱Ꮫࣂ࢖࢜ࢩࢢࢼࣝ◊✲ࢭࣥࢱ࣮㸪ࠕྛ✀ࣀࢵࢡ࢔࢘ࢺ࣐࢘ࢫࢆ⏝࠸ࡓ⬨㧊ᦆയ࡟࠾ࡅࡿ࢔ࢫࢺࣟࢧ࢖ࢺࡢᶵ⬟ゎᯒࠖ㻌 9) 㓇஭㝯୍㸸໭ᾏ㐨኱ᏛỈ⏘⛉Ꮫ◊✲㝔㸪ࠕ࢔ࣝࢶࣁ࢖࣐࣮⑓ࡢグ᠈㞀ᐖࢆᨵၿࡍࡿᾏὒኳ↛≀ࡢ᥈⣴ࠖ㻌ۍ◊✲㈝ྲྀᚓ≧ἣ㻌㻌 1) ᩥ㒊⛉Ꮫ┬◊✲㈝⿵ຓ㔠㸪ᇶ┙◊✲ C㸦௦⾲㸸ᮾ⏣༓ᑜ㸧ࠕ៏ᛶᮇ⬨㧊ᦆയࡢᅇ᚟ࢆ┠ᣦࡍ◊✲㸫ከ⬟ⓗ᪂つ໬ྜ≀ࢹࣀࢯ࣑ࣥࡢస⏝ᶵᗎ㸫ࠖ㻌 2) ᩥ㒊⛉Ꮫ┬◊✲㈝⿵ຓ㔠㸪ⱝᡭ◊✲ B㸦௦⾲㸸ஂಖᒣ཭ᬕ㸧ࠕ⣽⬊᥋╔ᩬᙧᡂ࡟╔┠ࡋࡓ⚄⤒㍈⣴෌⏕ἲ㛤Ⓨࡢࡓࡵࡢᇶ♏◊✲ࠖ㻌 3) ࢔ࢫࢸࣛࢫ⑓ែ௦ㅰ◊✲఍◊✲ຓᡂ㸦௦⾲㸸ᮾ⏣༓ᑜ㸧ࠕ࢔ࣝࢶࣁ࢖࣐࣮⑓ࢆᨵၿࡍࡿ᪂ࡋ࠸⸆≀࡜ࡑࡢศᏊᶵᗎࠖ㻌 4) ᩥ㒊⛉Ꮫ┬◊✲㈝⿵ຓ㔠㸪ᇶ┙◊✲ A㸦㐃ᦠ㸸ᮾ⏣༓ᑜ㸧ࠕ࠺ࡘ⑓ࡢࡍ࡭࡚ࡀࢃ࠿ࡿ࿴₎⸆㸸Ⓨ⑓ᶵᗎࡢศᏊⓗゎ᫂࠿ࡽ᪂つᢠ࠺ࡘ⸆㛤Ⓨࡲ࡛ࠖ㻌 5) ᩥ㒊⛉Ꮫ┬◊✲㈝⿵ຓ㔠㸪ᇶ┙◊✲ B ᾏእ㸦ศᢸ㸸ᮾ⏣༓ᑜ㸧ࠕ⸆⏝㈨※᳜≀ࡢከᵝᛶࢆ฼⏝ࡋࡓఏ⤫⸆ࡢỌ⥆ⓗ฼⏝ࣉࣟࢢ࣒ࣛࡢᵓ⠏ࠖ㻌 6) ᩥ㒊⛉Ꮫ┬▱ⓗࢡࣛࢫࢱ࣮๰ᡂ஦ᴗ㸦ϩ㸧ᗈᇦ໬ࣉࣟࢢ࣒ࣛ㸦ศᢸ㸸ᮾ⏣༓ᑜ㸧ࠕኳ↛⸆≀ࡢ㑇ఏᏊゎᯒ➼࡟ᇶ࡙ࡃᶆ‽໬ࠖ㻌 7 ཌ⏕ປാ⛉Ꮫ◊✲஦ᴗ㸦ศᢸ㸸ᮾ⏣༓ᑜ㸧ࠕ₎᪉⸆࡟౑⏝ࡉࢀࡿ⸆⏝᳜≀ࡢ⥲ྜ᝟ሗࢹ࣮ࢱ࣮࣋ࢫᵓ⠏ࡢࡓࡵࡢᇶ┙ᩚഛ࡟㛵ࡍࡿ◊✲⌜ࠖ㻌 8) ᐩᒣ┴ࠕ࿴₎⸆࣭ࣂ࢖࢜ࢸࢡࣀࣟࢪ࣮◊✲ 㸦ࠖ௦⾲㸸ᮾ⏣༓ᑜ㸪ศᢸ㸸ஂಖᒣ཭ᬕ㸧ࠕᐩᒣ┴⏘࿴₎⸆࠿ࡽ㛤Ⓨࡍࡿ⬨㧊ᦆയᨵၿ⸆࡟㛵ࡍࡿ◊✲ࠖ㻌 9) ᐩᒣ኱ᏛᏛ㛗⿢㔞⤒㈝㸦ᡓ␎ⓗ⤒㈝㸧㸦ศᢸ㸸ᮾ⏣༓ᑜ㸧ࠕᵓ㐀άᛶ┦㛵࡟ᇶ࡙ࡃ⚄⤒ኚᛶ⑌ᝈ᪂つศᏊᶆⓗ἞⒪⸆ࡢ㛤ⓎᣐⅬᙧᡂ㸦SR㜼ᐖ⸆㛤Ⓨࢆࣔࢹࣝࢣ࣮ࢫ࡜ࡋ࡚㸧ࠖ㻌 10) ᩥ㒊⛉Ꮫ┬◊✲㈝⿵ຓ㔠㸪᪂Ꮫ⾡㡿ᇦ◊✲㸦㐃ᦠ㸸ஂಖᒣ཭ᬕ㸧ࠕ⤫ྜⓗ⚄⤒ᶵ⬟ࡢไᚚࢆᶆⓗ࡜ࡋࡓ⢾㙐ࡢసືཎ⌮ゎ᫂ࠖ㻌ۍ㠀ᖖ໅ㅮᖌ㻌 1) ᮾ⏣༓ᑜ㸸࢔ࣝࢶࣁ࢖࣐࣮⑓࡟᭷ຠ࡞₎᪉ฎ᪉㸦ᖐ⭁‮㸧㸬₎᪉⸆࣭ ⏕⸆⸆๣ᖌㅮᗙ㸪2012, 8, 19㸪ᮾி㸬ۍ◊✲ᐊᅾ⡠⪅㻌 Ꮫ 㒊 3 ᖺ ⏕㸸ᕤ⸨ฑ⣪㸪ᑎᓮ⣪᭷⌮㻌 Ꮫ 㒊 4 ᖺ ⏕㸸⏣㎶⣖⏕㸪すᏊ⿱❶㻌 ኱Ꮫ㝔ಟኈ 2ᖺ㸸ᇳ⾜⨾ᬛᏊ㻌 ༤ ኈ ◊ ✲ ဨ㸸ᯇỌᬛᏊ㸦2012, 9ࡲ࡛㸧㸪ᮤⱥፑ㸦2012, 10ࡼࡾ㸧㻌 Ẹ㛫➼ඹྠ◊✲ဨ㸸ᓲ⪷㈼㸦2012, 12ࡼࡾ㸧㻌 Ꮫ ෆ ◊ ✲ ⏕㸸Ώࡾⱥಇ㸦ᐩᒣ኱Ꮫ་Ꮫ㒊࣭࿴₎デ⒪Ꮫ㸪2010, 10ࡼࡾ㸧㸫㸫―45―

神経機能学分野(病態制御部門,各部門・附属センターの活動と業績)

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神経機能学分野(病態制御部門,各部門・附属センターの活動と業績)

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