Research of traditional medicine is important to maximize the utilization of natural resources. Artocarpus champeden Spreng. is one of medicinal plants that must be studied because a lot of diseases have been treated traditionally with this plant, such as cancer. Phenolic compounds such as flavonoid, tannin, phenilpropane derivative and simple phenol contained in medicinal plant have been proved for their immunomodulator activity. This study was conducted to explore whether flavonoid of Artocarpus champeden could also increase the activity of immunocompetent cell that
play an important role in immunity against cancer especially to Cytotoxic T Lymphocyte (CD8+). Assay of cytotoxicity of CD8+ by MLR (Mixed Lymphocyte Response) showed that DE. 6.4 fraction (contain flavonoids) could not stimulate the activation of CD8+ significantly (p<0.05) at all concentrations compared to the control
