Immunomodulatory activity of four fractions from Plantago major L. (n-hexane, ethyl acetate, n-butanoland water) on titer of IgM has been carried out on mice, ex vivo. Each test sample was taken orally during 7 days, single close, at 3 different level close . Titer of IgM has been determined using agglutination method, 5 days after immunization with sheep red blood cell (SRBC). All of the fractions has capability in increasing the titer of IgM, but the highest activity resulted from n-hexane fraction
