Modok, Szabolcs

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Modok Szabolcs

SZTE  Doktori Értekezések Repozitórium (SZTE Repository of Dissertations)

3D microvascular architecture of precancerous lesions and invasive carcinomas of the colon.

An experimental and mathematical model for the extravascular transport of a DNA intercalator in tumours.

Atomic test of the Stokes-Einstein law. II. Diffusion of Xe through liquid hydrocarbons.

Cellular distribution and cellular reactivity of platinum (II) complexes.

Cellular processing of platinum anticancer drugs.

Cisplatin rapidly down-regulates its own influx transporter hCTR1 in cultured human ovarian carcinoma cells.

Cisplatin: mode of cytotoxic action and molecular basis of resistance.

Comparative efficacy of novel platinum(IV) compounds with established chemotherapeutic drugs in solid tumour models.

Comparison of IgG diffusion and extracellular matrix composition in rhabdomyosarcomas grown in mice versus in vitro as spheroids reveals the role of host stromal cells.

Confocal microscopic analysis of the interaction between cisplatin and the copper transporter ATP7B in human ovarian carcinoma cells.

Cytosolic region of TM6 in P-glycoprotein: topographical analysis and functional perturbation by site directed labeling. Biochemistry.

Detection of cellular platinum using the monoclonal antibody 1C1.

Diffusion and convection in normal and neoplastic tissues.

Diffusion: mass transfer in fluid systems. Cambridge:

Dinuclear platinum complexes with N, N'-bis(aminoalkyl)-1,4-diaminoanthraquinones as linking ligands. Part II. Cellular processing in A2780 cisplatin-resistant human ovarian carcinoma cells: new insights into the mechanism of resistance. J Biol Inorg Chem.

Distribution and subcellular localization of a water-soluble hematoporphyrin-platinum(II) complex in human bladder cancer cells.

Down-regulation of intrinsic P-glycoprotein expression in multicellular prostate tumor spheroids by reactive oxygen species.

Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of tumours.

Factors that influence the penetration of methotrexate through solid tissue.

Gene expression profiling of Caco-2 BBe cells suggests a role for specific signaling pathways during intestinal differentiation.

High interstitial fluid pressure - an obstacle in cancer therapy.

Inhibition of P-glycoprotein function by XR9576 in a solid tumour model can restore anticancer drug efficacy.

Intra-arterial chemotherapy of primary brain tumors.

Limited penetration of anticancer drugs through tumor tissue: a potential cause of resistance of solid tumors to chemotherapy.

Maximum geometrical hindrance to diffusion in brain extracellular space surrounding uniformly spaced convex cells.

Measurement of extravascular drug diffusion in multicellular layers.

Microtubules as a target for anticancer drugs.

Modulation of multidrug resistance efflux pump activity to overcome chemoresistance in cancer. Curr Opin Pharmacol.

Morphologic criteria and detection of apoptosis.

Multicellular membranes as an in vitro model for extravascular diffusion in tumours. Br J Cancer Suppl.

Multicellular resistance to tirapazamine is due to restricted extravascular transport: a pharmacokinetic/pharmacodynamic study in HT29 multicellular layer cultures.

Multicellular resistance: a paradigm for clinical resistance? Crit Rev Oncol Hematol,

Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo.

Novel nanoliposomal CPT-11 infused by convection-enhanced delivery in intracranial tumors: pharmacology and efficacy.

P-glycoprotein in adult solid tumors. Expression and prognostic significance.

P-glycoprotein retains function when reconstituted into a sphingolipid- and cholesterol-rich environment. J Lipid Res.

Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogs with improved tissue penetration and hypoxic cell killing in tumors. Clin Cancer Res.

Pharmacokinetics and metabolism of vinblastine in humans.

Pharmacologic analysis of drug-receptor interaction.

Poly[N-(2-hydroxypropyl)methacrylamide] polymers diffuse in brain extracellular space with same tortuosity as small molecules.

Purification and 3D structural analysis of oligomeric human multidrug transporter ABCG2. Structure.

Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction.

Recognition of cisplatin adducts by cellular proteins.

Relationship of the expression of the multidrug resistance gene product (P-glycoprotein) in human colon carcinoma to local tumor aggressiveness and lymph node metastasis.

Resistance of MGH-U1 bladder cancer spheroids to vincristine.

Robbins pathologic basis of disease.

Simionovici A and Somogyi A, A library for X-ray matter interaction cross sections for X-ray fluorescence applications.

Slow penetration of anthracyclines into spheroids and tumors: a therapeutic advantage?

Structural studies of vinblastine alkaloids by exciton coupled circular dichroism.

Structures of leurocristine (vincristine) and vincaleukoblastine. X-ray analysis of leurocristine methiodide.

Studies of the binding of a series of platinum(IV) complexes to plasma proteins.

The cellular distribution and oxidation state of platinum(II) and platinum(IV) antitumour complexes in cancer cells.

The direct mapping of the uptake of platinum anticancer agents in individual human ovarian adenocarcinoma cells using a hard X-ray microprobe.

The expression of P-glycoprotein does influence the distribution of novel fluorescent compounds in solid tumour models.

The hypoxia-activated ProDrug AQ4N penetrates deeply in tumor tissues and complements the limited distribution of mitoxantrone. Cancer Res.

The importance of cholesterol in maintenance of Pglycoprotein activity and its membrane perturbing influence.

The influence of expression of P-glycoprotein on the penetration of anticancer drugs through multicellular layers.

The mathematics of diffusion.

The mechanism of action of platinum(IV) complexes in ovarian cancer cell lines.

Thioredoxin expression is associated with lymph node status and prognosis in early operable non-small cell lung cancer.

Three-dimensional structure of P-glycoprotein: the transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state. J Biol Chem.

Transfection efficiency and toxicity following delivery of naked plasmid DNA and cationic lipid-DNA complexes to ovine lung segments.

Transport asymmetry in peritoneal dialysis: application of a serial heteroporous peritoneal membrane model.

Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors. Nat Med.

Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxia-targeted anticancer drugs. J Natl Cancer Inst.

Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors.

Three-dimensional models of chemotherapeutic agent transport in tumours

http://doktori.bibl.u-szeged.hu/623/1/Modok_Szabolcs-thesis2010_msz.pdf

Three-dimensional models of chemotherapeutic agent transport in tumours

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SZTE Doktori Értekezések Repozitórium (SZTE Repository of Dissertations)