Structural Brain Connectivity in Aging and Neurodegeneration

Abstract

As our life expectancy rises, the prevalence of common age-related brain diseases such as cognitive decline, dementia and neurovascular disease will increase. Effective preventive and curative interventions are scarce, whilst causative factors remain largely unknown. The role of cerebral white matter in age-related diseases has been established. However, macrostructural white matter changes, which are visible on a conventional MRI, constitute only the tip of the iceberg of the white matter pathology that have occurre