This paper investigates the potential use of neem (Azadirachta indica A. Juss) aqueous leaf extract on the growth, yield and disease control of a common vegetable plant tomato (Solanum lycopersicum L.). The neem extract increased shoot height, number of branches, number of leaves, number of buds, number of flowers and number of fruits of tomato plant over controls in different treatments. Numbers of diseases were calculated as percentage and disease/plant. The percentage of reduction of disease was calculated after the spray of neem extract on plants. Neem extract was found effectively in controlling canker (50.32%), early blight (55.12%), wilt (59.45%), leaf spot (55.48%), fruit spot (41.93%), blossom end rot (40.86%) and sun scald (25.61%) in comparison to controls under field condition. Thus, biopesticides can contribute in reducing use of chemical pesticides and subsequently minimize its hazards to the environment and human health