The present study offers an overview on stigma against transgender people, analyzing its effects on physical and psychological well-being. We adopted a socio-ecological perspective, according to which antitransgender stigma may manifest at different levels: along the environment-individual spectrum, stigma may occur at the institutional, interpersonal and individual level. All these typologies make transgender people a very vulnerable group, at risk for several health problems. Authors will finally overview some specific psycho-social interventions aimed at reducing stress, by matching each level of stigma with internationally well-established good practices