The objective of this study was to evaluate the effect of
commercially prepared spray-dried ethanolic extract
ol Andrographis paniculafa (AP) on streptozotocin
(STZ)-induced diabetic female rats. METHODOLOGY:
Rats with regular estrous cycle (EC) prior to STZ
induction were randomly divided into five groups. The
normal (nondiabetic) and diabetic controlgroups were
given vehicle [0.2 ml of 2o/o carboxyl methyl cellulose
(CMC) by gavagingl daily for 6 weeks. Other diabetic
groups were treated with 50, 100 and 200 mg/kg/day
of AP extracts respectively. The rats' body weight
(BW), fasting blood glucose and insulin level were
measured; and daily, EC evaluation was perfo;.ry1e.d1
throughout the 6-week study period. At the end.olthe
experiment, rats were sacrificed and their P4fprpases
were removed for histological examination."RESU LTS':,
The survival rates and estrous cycle,'$f''AP-treatbd
diabetic animals were found to be improved compared
to nontreated animals
