Reza Khani, Soheila

Simorgh Research Repository

OlrX* oail.rq r;9l.r.i pl;14lTluiblAts**uK*;2 ri;fl9 4br.t,aih4t c',r$9Ot".f ,-,(,,31l" peb ottu;lr4lof .jL;r Ft{; cita*i 9 Ji.j;r, pgls alsl;L;lrP *" :fl {:J_t,r. -.,-;af t gjf t-o.6 OU.,",./f -rl9 ii" Ata r.S.lt^*f .,S;f e,a,a:.J.SlitJ a21,r c*!L1o c"q.>;ni ,;.tr- Jy;il q Olr["*: .1r }b J$ u*, tt ef * 1r logrb ! a*,-ti." ; 2s;5 orl,os gLzr lpb:t";al; ok*+l.sl',-r- jl+,;5r pLilE;*:.;9Lia a{bl.,,ndj o96 y6r.JGl./ti",j;by" urlf i5) .Slsl ?t+,,j.rtft r cFar!,.,lEB1 Y.+r" Ft:( ,rrti+ird f1. / 0.6*ijb) G.ii, ptotjt J*.6tof jt"p .,Jt*e oto*i 9.rS*i;r- plc olst,.iibcsrstt5 .i**;l 9F.rh/-lt"ot ot;4ra ;iytr ab.,t"o:'r1f ,i.r.,ril u-Lt U* 41-). OJrl(Mild-cognitive irnpairment (MCI)) -iJ; Lj:ili-:;,\'):. ,J.rl,. --Lu:,-1;s1 |r.)ri.r:la,-l ,i-: ,*-jltty L_ll"i t_ )*.1)i L-e; af ;Lr '* 4r (MCl) ..-i,r:r --(*:j *'_;:.. .JL ,: .r.liU *. MCI aLr. ,: clr<;.1 pluel a;91 r" r$l a\ AG) dr-)-{? ,sr-L) cJ," }'G )f ,:- 1 +, -.jl4?t,i )l ,Bosweilia Serrata of ;1 or.1 cd+ e"- rrJ.c-l o.ri -Ljl ).tgn &:o ,y-l i 6iy rLr: g-- 3-ou yE dE. e^ Ll .:*l o:9, o.:l-oil ;19. 6r.l{- orlas 9 alast> or-o.: ":"-l;il ;l9a uVlll s rUI J " d- .=- .-L-i $ MCI )t1l A. ,JIr-l .r:V.f i,rf ,-s- 9r o.u i:L; -..lL **u;irf aJU-.5-- r: l\.i91 9 :r-)h abrL* { $ri )) & c; e oL;_LJ e MRI L-; ;,Lrs Jt .,!l,;sl .51,o ..p;; e .$-r,i o.:l: o.nrslr i*}13 fi osf I )s; i r! rr mB Y.. ,d olL* J91 otf ,s:*:i o:.a ogrS t) n..rl,,L*.rl.r-i o:l: tt+,,| ( .rl;..r;rrl ;"iL_rr oL a- :- -.r-i o:l-i;l Ttest ,r;i ;l k*1,5 a.--G. c.qa i s rl+l al>l.r- ;l L+ I Joi Moca T....5121:;l,l . : Fi..t.J.;)p ))".rlrL*;l (n=54).rl,,Lg - ,:?Ylb gAlY? .31ra:lLrrld\ al,,L*.r-;Jl;!:p_1;,.(r-r: Y/A) r;;:15 .*1".,1 o\,.>.; ,y-rS I (ur: A\/f) $:y ;kry: oV1e, ::9r ea atiL ,e-b U-l .rLl .,.r (YY/f . /1, ,: YA/VY) r:::1lr aEh.;l ,- MOca ;*; J**t* ol ;.: .r--q,. c,G){:;l ....j .-.( p-value< ..... \)c-il: .r-te jt&l a&V e il ylt *V;,.F+ aliiL ,sz t )y rl: ;* .s),(:il s'-: '. --.:rb.r:;i:*iJ).{:;lLrl)1"*r:al"sL,Sst.* ol;l BosweiliaSerrata.!)*,4Jtt-D,-1 d"Ll y:6s$ a>-;ty:s?. Lstt BS ol;1 ,s.L)) s\ F+;Ult ,.r.r &L.ri., BS ;YL.5lo;e: c,r" jY+ r-s)-" \t'^ c,i,;' *- ..)?, cs" rltr-j* MCI ,-,l.rL*.,, .,,.l '. _- '-;,lr-l ,Moca test ,,li' Jlel .( Bosu,eilia Serrat )rxt , *;; ,rai oYV>l :6-rJ<or(>AbstractBackground: Mild cognitive impairment (MCI) is the first stage of dementia and i:,increase the risk of Iater progressing to dernenti4 caused by Alzheimer's disease or u-rr:'neurological conditions. The best time to do any preventative measure is in the MCI staee. -.now, no effective treatment has been approved at this stage. Bosweilia Serrata (B S) has be, -used for increasing memory and learning skills by Iranians and Muslims since man), \e;::ago, but tliere is not any published article in this area. The aim of the present study uas ,investigate the effect of Bosweilia Serrata on memory in patients with mild cognir :impairmentMethods: In our randomized double-blind clinical trial, 80 MCI patients were diagnos=-by Neurologist and treatable diseases with differential diagnosis were excluded by MRI . i.:data (TSH, AST, ALT , BLIN ,Cr , Ca, CBC , FBS) and Beck test then they were referred .Shafa Hospital, ( Kerman, Iran ).The enrolled patients were divided in the two groups. T:=first group received Bosweilia Serrata 300mg twice a day and the second group receir.-placebo for a duration of 3 months. MoCA test was done before and after the interventiiData analysis was perfonned using t-test.Result: Mean age of patients was 66.52 + 8.46 years and 67.5 % (n:5a) of the patie::jwas male. The rnost frequent educational level was high school education (51.3%) and t:.least rvas Master of Science education (2.5%). The two groups showed significant differen-.in their Moca test- mean score after the intervention. (25.72 vs.22.40) According to :-:results, Memory item had the greatest irnpact on the average final score. (SO.OOOt;Conclusion: According to this studl'. Bosu'ellia Serrata has positive significant effeci , -memory in patients with mild cognitive impairment Due to beneficial effects of long : - -administration of higher doses of BS on rat memory, further studies suggested for - .assessment of BS effects on improvement of cognitive impairment in MCI patients.Keywords: Mild cognitive impairment. Bos\\ eilia Serrata, Dementia, Moca test, Iranaa aaa..S..f;r, uijfi I gLors .-,Ji,l+qr crrt;9.;b;5 .,rbp 9 .,rjli.q; crb.ri 9 .J.lf pglc ol,Ii-Ljlsls+jli ..jij9"i - .rS.f;1 o.rsi^ijlc#B[jt Y*{#;5c ,rJ*.aer;. a"U Ot-t"\-^J->Jlt., c-r.::,-;l S#* rc L;9r1.: l+ o*,-ti. ro ru.S o.rl^. ;Lr.: _rJU .*.rr* : ;l9r ;.a;(Mild cognitive Impairment - MCI) ,r..o.: .i.d Jy,'l tr ,-rl.,tr* ro Jiiecfi | yty caa;;;,.gl,":SJ a+.;o .:.iL_r.lr1*-:11lAf or*; J-flL# li: tG. csz9lo ++.. p;>...9l;c19 L*,_nf a.r.Ll."( *.o.-r"[:f'i .r,L:Yil'lJ ii1"r-:;Lx3 rt"19t&, Jti.-,|,.,rq.i.j, o9t5 r:Sc.;il.:r, .r"t , i5,aoU,',Lrtr .*,v..rg !i'- p-' .r*:- .::f gr-:.pH- ,rL, ,.: b uL.rl.,,. +t rr . -::S: *b O!L_ .gla <;; ol*; * 9.f-"S; 6is:;l;- { rri ,l *"rlr *.. ;.:.c9*i L;l 9.4- ta r.U ;t ! .*r,-: g Lal, r_Ll L ;t:_je;> L 1f /f /tr &.ru ,,".r.rf .,l,.6 r.,_L-l.oi.olJ *J't"f,L-.:l:-l3{a$\lt!LoL,_q;l6Lio

تاثیر درمان عصاره کندر در مقایسه با دارونما در جلوگیری از پیشرفت زوال عقل در بیماران با اختلال خفیف ذهنی

http://eprints.kmu.ac.ir/27078/1/6481_20180408_0001.pdf

تاثیر درمان عصاره کندر در مقایسه با دارونما در جلوگیری از پیشرفت زوال عقل در بیماران با اختلال خفیف ذهنی

Abstract

Similar works

Full text

Available Versions

Simorgh Research Repository