Akhondipour, Majid

Simorgh Research Repository

e)lP,Qr,t, -., ?rl.{, 6go.rli,il.l69 t d;,= cr,j,l aa, .r-&;l,r*,t "' l', 1S gt3.o 19 a- t-l;litt:AlJj.\ Y1P- \ YtV:.1-,,--: Jt .,/yaJ,Yl.ratS-.r.,L;T csL^"i-r- -,.1 .r*l-l-+"'<t 6;i ol;i -fti "'1""' r#J]-rsi crJrJ=i .l-,--: L "'-f:k6lJ J:it-lcs&-l-r ,r-0*3s ,'sJ. -rK.cs#l ,;"-l;$:-2yL;- :k-l.ll-ii csJi;*, l;t yS,UKerman IJniversity of Medical SciencesFaculty of HealthyIn Partial Fulfillment of the Requirement for the MSc DegreeTitleToxicity evaluation of molybdenum trioxide nanoparticles in Rats.ByMajid AkhondiSupervisorsDr. Ali Faghihi ZarandiDr. Asghar AmiriAdvisorDr. Reza YaziriNejad2018o+5"9 r8 oV9.; t ,ril:*" (NPs) ol.,i 9;U,rl9.,r-''r.:-q.' g rsilrt',jyB 'frF-' !:r'6t'ul 9 4oJso:19. ;yl ,a-l asL;b rlly 1l etV-. r: br1 ,r*, ol;l .JtJl+, tfu-l ,""2,-J" 9 c'-'l o'r';)a:!L ,'rtByyl; "xl ;l .c*,1 o:f inl+ .:9 { lr cr)t-j c"i o;9yl .tvSl csi ,t-r orli 9;l; '$lcrit- otfl)il.5bry;Lf.jLbjUI li t ,trf dj2r*o .,lroJbK ,&,+tlf ,l*JbK,ilgto{ 9 djt'1;1; tu'o I q5lo'roc rgta' ol.1!,;iF.9;iJL otr;, c-l ;(- s.,b af .5lt-;419s 9 o;*S:.u.,tl rot,,,,,lc ;17 ;l 'rycr' o:U;l pglo.yl, o+ ,rclir .5lor-.,2 $liq rly ,-1,-l b lf.r os! oll! ,b *f o;lsl l;; '"ri"i! zuil: ol.po { ni9 toJ+ .slq t ,i.(; ,$.; .ri9., y :ly ;,1 vlLU 9 ,r*, JL;>l olll 9 yb ,sts!ir.,2rl5 q a;y l+ 'r-J.5t6d,r, ,j{ dtbc^iU I of ), ,qJr +S ,Si olri 9;U 4 dsf.iu! oirlji g1l '6l1ls$.S,5 rr+i*nrtu-t,JF "tf a- + bcrr .-"f )P o:lal:1y PF \' '* \' .li, J.*t " lr ',-Fr ,- Y' :;;i:ti ,;;i9,o4 ct)s ilgN r pf J* \' I A jrr !..,dr a.Sl 6; e:b su *.*a:[; s $ )* 11 aLl'r" oef e.slrr at4toelsl 9 ;p {f I o"$auJ oL;19,- r+ nl'r r)'s &r.ii b,ir q j2 YA d'1" {'Jr.:,,i ,gf ollsl At,,i ! c+l.rr+ ,-frst qOlr*Jf cJalc c.,-14,1':' r; Li)91e^" Or*Jf ;'ly 6r$o;lsl,**.,F-, ogF sr ! u*,-E 1: c,lr! yU e,5,Jo" \' )sr $.:lr 6Lr ,;t> 5;zs 6'-h;:bcltt-o:l:,-;rl5 tr (P<./.r) +; t rp el^J#.(P<./.t) co/rr^.(P<'/'l) .-,-t'yt 611-;lr.;-Lf.:.J;l gri J ry-l tl sla:rt-raV ur.st"crJ)'tr.:lu,ol! iE ff & \' r A Je: !;;;pr e '*.,l,.*l!i ,: o+Jr :o,sl 6,; olri ;U a\:* s:l: ;l;; eb jl L5i'i '( P='/\YY) c*rl o:9*i lb.p* t5,L11lr.-+* rP+,&r osF st ! a*,-tL r: slor-i+-j; rf N n Pf & \' jP lr at.r-ln.vr S t S.,:rl o:9,, ;Y! (P<'/'t)r') Vr*.5b,-Latro r: ;+Jr 4*51 ol.;i 9;L; af .:l: "1tr.1a ir.,-l , &b p-t:;:t5;5a51 I b."xl e-b..:2lr g",-L .5bctls !.,--U, i .-fP s Gf *1lh v 6frt c'5- il GF*S N Pf ,*r: O+Jr+Jl .52; ol.zr ib ,.* Lgtrf Jt-l I r9^, r*b l2 ;+Jr+rtl .5/ ol.2! 9;b ..-*- a'Jtt")l l4lii*I-b,,U e;l;ti*i;!l!'i,;I.'i;fr,l i,rVI.sto,.,iJ o;; r:1l;ilat-leal .-;bL c'tG er9 aJ rfLc 1: JVSI )h-l .i.)t jl to.-ir +r** acl2 'l'rgl eP P &lj'l I ts+5 titnJ,l-.)/ $ ?-P 9.s{5.rtoJ+" in*'"'ic,.r .sb,jr,d+Jr.-!#51 .5/,olp 9;U ":v-- :Dit9+.15.ji'. -;:.,'aa :; . :.:-:.:..-::-:aa'.--i\ . . 'AbstractBackground and objectives: Nanoparticles (f{Ps) have been created with a ,.* urdemerging characteristics with the development of nanotechnology and material engineering,and these materials have also been increasingly used despite their potential toxic effects areunknown in many cases. The nanoscale of molybdenum trioxide has athacted a lot ofaffention today. These nanoparticles are mainly used in the industry, glass and as crackingcatalysts, hydrogenation catalysts and the production of refractory alloys. In spite of theirwide range of uses, these materiais may have potentially harmful effects, as the small size ofthe nanoparticles allows them to overcome the body's defenses. Regarding the application ofnanotechnology and the possible effects of these substances on the growth, proliferation andsurvival of cells and organisms, this study was to investigate the toxicity of molybdenumtrioxide nanoparticles in blood and body tissues of rats.Methods: 30 wistar rats, with a weighing average 200 + 10 g were used. Rats were dividedinto three groups: control and intervention group with high and low dose. Molybdenum nanotrioxide (5 and 10 mg / kg body weight) was injected to the rats for 28 days. At the next stage,the animals were sacrificed and blood samples and their organs were collected to measure themolybdenum content. Ultimately, molybdenum concentration was measured by flame atomicabsorption.Results: The results of this study showed that 10 mg nanoparticles significantly has reducedhematocrit (P <0.01), hemoglobin (P <0.01), red and white blood cells @ <0.01) compared tothe other two groups. Also, with 5 and 10 mg nanoparticles, the number'of plateletsdecreased, but this decrease was not statistically significant (P : .122). Part of the resultsshowed that the amount of molybdenum trioxide nanoparticles in the heart, liver and kidneysof rate who were fed with 10 mg / kg was significantly higher than the other two groups (P<0.01).Conclusion: The results of this study showed that nanoparticles of molybdenum at highconcentrations (10 mg / kg) had a more toxic effect on blood and serum parameters comparedto low concentrations. The results of this study confirmed the toxicity of molybdenumTrioxide nanoparticles and it is likely that the administration of molybdenum tioxidnanoparticles at two different concentrations due to an increase in the leakage of alanineaminotransferase, alkaline phosphatase and aspartate aminotransferase enzymes from livercells and their elevated serum levels leads to poisoning the rate through causing impaired liverfunction and damage to liver cells and liver damage.Key words: Toxicity, Nanoparticles, Molybdenum Trioxide, RatstLi +^^..,a.b ..,t-1, ;l gLio a.-W)y;,tf *S-;1 e*.l53rr"t33ls *L.S- o)1.--', c '; ;l ,s .;U ;* . - rS " ..1l-r c.:.; Sl oitf c-il*r L#qf ujJl .,-LdJ[5 sX 6$fi .r*2, 6Gi ;+.^: +"U gL-L, +.cGs +-l7v) J J - g.+y-t-p f)Ll ;*j J++ ;LJj ! .sr**l )'<l .{r-,.,+r,i! .*;5" ;L-Gi ,r,-t.:-1; { " ,rol5;,-L;i .5to ,-ir;r ,+Jr +J4rLN\l u; Jrlit- rb I eUn'/q> ".Ai*,,Ic;5.: .5t!i-\s*l r-l;Sc.91!i -Y L-.e.! (gl).:L-l:,:Jl-t{..)/,r',\y U "U s-ilt L;., ySs 6t!i - ,-sf (;l)rt:;l '-sl; ,=-*ta r,-U yfs 6t!'[ (,rl;ls) glrgls ol,^ Eis:4f.;lL;r,t^-*;Sc 6t!i (;>.t9) 3lr9ls oLo +;e: r7 "fl--,I ary=.. .1:5c n;L> ,jl+^SJ o)l...rU ou;r-k!l oLs-)Y.l/,.......... c.'r t'

بررسی سمیت نانوذرات تری اکسید مولیبدن در موش های آزمایشگاهی

http://eprints.kmu.ac.ir/27076/1/6480_20180408_0001.pdf

بررسی سمیت نانوذرات تری اکسید مولیبدن در موش های آزمایشگاهی

Abstract

Similar works

Full text

Available Versions

Simorgh Research Repository