Yousefnia Babaki, Mahdieh

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Considering that animal studies are controlled andconfounding factors are much less than human studies and there is no limitation forhistological studies, in the present study, the effect of long-term adrninistration ofnandrolone decanoate on histological changes of the heart and the parameters of the ECG inthe presence of endurance exercise with mild and severe intensity in male rats.Materials and Method: Animals were randomly divided into 9 groups of 8, whichincluded control group (CTL), Arach group: Nandrolone solvent was received twice weeklyfor 8 weeks, 0.2 ml, im, Nan group: Nandrolone received a dose of 5 mg / kg body weight(0.2 cc) twice a week for 8 weeks, Mild exercise group (mEx): was 8 weeks under Lowintensity endurance swimming exercise, severe exercise group (sEx): ): was 8 weeks underhigh intensity endurance swimming exercise, Arach + sEx, Arach + mEx Group, the Nan *sEx group: treated with nandrolone and severe exercise for 8 weeks, Nan + mEx group:treated with nandrolone with mild endurance swimming for 8 weeks . One day after the endof the testing period, weighing was done. Animals anesthetized and their electrocardiogramwas recorded. Animals were then killed and their hearts were removed for stereologicalexamination. Results were expressed as mean * standard error. One-way ANOVA test wasused to compare the parameters in different groups and a Tukey test was used forcomparison between groups. Statistical tests were performed using SPSS 20 software and asignificant level of 0.05 was considered.Results: Both types of exercise reduced the heart rate and significantly increased RRinterval of electrocardiogram (ECG) in comparison with the control group. In this regard"the effect of intensive exercise was higher, but the difference in the effect of two differentmodels of exercise on these two parameters did not reach to the significant level. The use ofnandrolone reduced the decemental effect of severe exercise on heart rate and RR distance.Exercise and nandrolone alone and in combination had no effect on other components ofthe ECG. Nandrolone increased the index of left ventricular hypertrophy compared to thecontrol group (P <0.05). The combination of nandrolone with mild and intense exercise wasalso accompanied by left ventricular hypertrophy. Light and heavy exercise alone did notshow a significant effect on left ventricular hlpertrophy in this study. The volume ofmyocltes in mild and severe exercise groups with nandrolone increased significantly @<0.05). Left ventricular volume was significantly higher in all training groups compared toNan, CTL and vehicle groups (P <0.01).Conclusio[! In general, the findings of this study showed that light and severe exercisecombined with nandrolone for eight weeks reduced heart rate, increased RR interval,ventricular hypertrophy and myocltes volume. No significant difference was found in theeffects of nandrolone combined with extreme swimming exercise on the cardiac parameterswhen compared with mild swimming exercise plus nandrolone.Keywords: Nandrolone decanoate, Severe endurance exercise, Mild endurance exercise-ECG, Heart tissuea.rS-r;g.rtjfI I Oblo c^.$l*q r1l;9irl.Jt dt .ro, rs:.ilqt r.rb.ri 9 ,"(.f;1 pgls oUlijlo,s..rq,jjr"i -,rS.f; o.r.fu,iloaoU Otr_l+ jleLic ."*t+i oF,"*tf l* ti-X qu"ar"rto .,IaiarE +"U Olr-t,cst{c.ri tr d.li-,! ..1i22t ! 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بررسی تاثیر تجویز مزمن ناندرولون دکانوئیت همراه با ورزش استقامتی با شدتهای کم و زیاد بر پارامترهای هیستولوژیکی و نوار قلب در موش صحرایی نر

http://eprints.kmu.ac.ir/27065/1/6473_20180408_0001.pdf

بررسی تاثیر تجویز مزمن ناندرولون دکانوئیت همراه با ورزش استقامتی با شدتهای کم و زیاد بر پارامترهای هیستولوژیکی و نوار قلب در موش صحرایی نر

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