In the past decade, there has been an increasing awareness in development of sustainable manufacturing systems as governments in many countries have been enforcing ever-stricter environmental policies and regulations in industry by promoting energy saving and low emissions manufacturing activities. Lean manufacturing can be helpful for achieving a sustainable manufacturing system as it can reduce production wastes and increase manufacturing efficiency. Nevertheless, this lean approach does not include a consideration in energy consumption and carbon dioxide (CO2) emissions when designing a lean manufacturing system. This paper presents a methodology which can be useful for measuring energy consumption and CO2 emissions for a typical manufacturing system design at an early stage. A case study was carried out for obtaining computational results using the developed methodology based on data collected from a real production line