Figure S2. Founder contributions and haplotype around Stsl3 QTL on Chr 1. (A) Genome scan magnification for Stsl3 QTL region (70–100 Mb on Chr 1). The mouse genome location is on the X-axis and significance (−log10(P)) values on the Y-axis, with genome-wide thresholds of association at E < 0.5, E < 0.1 and E < 0.05 levels indicated respectively by the gray, orange and red lines. Peak locations Stsl3a and Stsl3b (maximum value of –log10(P)) are marked by stars. (B) Founder contributions in the same magnified region. The peak location of Stsl3a is marked by a star. Each of the 8 founders is in a different color. The mouse genome location is on the X-axis and Y-axis shows the founder estimated effect on splenic bacterial load after S. Typhimurium infection. (C) Founder contributions at Stsl3a QTL peak (83.9 Mb). X-axis shows the different founder strains. Y-axis shows the estimated founder effect. No obvious contributions explain Stsl3a QTL, but B6 (grey) has the highest estimated impact of the 8 founders. (D) Founder contributions at Stsl3b QTL peak (79.2 Mb). There is no obvious founder contribution for Stsl3b QTL peak region. 129 (pink) has the highest estimated impact of the 8 founders while PWK (red) has the lowest estimate. (PDF 215 kb
