Parsons-Wingerter, Patricia A.

NASA Technical Reports Server

1 
 
NASA’s Innovative VESsel GENeration 
Analysis (VESGEN) Software 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Vascular Patterning for Research Discovery and 
Technology Development 
 
Patricia Parsons-Wingerter PhD, NASA 
Biomedical Research Engineer, Lead VESGEN Innovator 
 
New Organ Alliance & NASA Vascular Centennial Challenge 
Chair, Vascular Imaging, Computational Analysis, Biosensing Committee (ICAB)
 
 
 
VESGEN Patent Pending 
Arterial  Tree Vascular Network
https://ntrs.nasa.gov/search.jsp?R=20180001991 2019-08-29T17:40:13+00:00Z
2 
 
 
New Organ Alliance & NASA Vascular Centennial Challenge 
 
Vascular Imaging, Computational Analysis, Biosensing Committee (ICAB) 
 
Actively recruiting members with vascular imaging and other expertise! 
 
 
 
Lisa Carnell, PhD  Senior Research Scientist, Human Research Program, NASA 
Tissue engineering, biosensing, microvascular remodeling 
 
Jennifer Fogarty PhD  Chief Scientist, Human Research Program, NASA 
Angiogenesis, microvascular remodeling, role of biomarkers  
 
Antony Jeevarajan PhD  Deputy Division Chief, Biomedical Research and 
Environmental Sciences, NASA: Biomedical research, imaging of cell systems in 
bioreactors for tissue engineering 
 
Krishnan Radhakrishnan MD PhD MPH, Senior Scientist/Epidemiologist, Veteran’s 
Administration, West Haven, CT: Computational and medical analysis of microvascular 
remodeling in clinical and microscopic images   
3 
 
 
NASA’s VESGEN 
Vascular Centennial Challenge Collaborators 
 
 
    
•  David Kao PhD, VESGEN 3D Mapping and Quantification; Visualization 
  
•  Hamed Valizadegan PhD, Rodney Martin PhD, Nikunj Oza PhD, AI/Deep Learning for 
Vascular Image Binarization 
•  Mary B. Vickerman MS, VESGEN 2D/3D Image Analysis and Java Developer 
•  Mark Lagatuz MSE, VESGEN Java Developer 
•  Matthew Murray BS, VESGEN Vascular Analysis Early Career Scientist 
•  Ann-Sofie Schreurs PhD and Candice Tahimic PhD, Heart Vascular Branching 
•  Undergraduate Interns:  Sneha Ramesh, Marina Predovic, Cassandra Stawicki 
 
 
 
 
  
 
 
 
 VESGEN 2D 
Translational Mapping and Quantification 
 of Fractal-Based Vascular Pattern 
 
 
 
•  Overview of VESGEN applications to vascular mapping and 
quantification 
•  VESGEN software scheduled for public release by NASA in 2018 
 
 
 
 
 
 
 
 
4 
VESGEN Patent Pending 
Human Retina Mouse Retina
WPanel to specify 
vessel type 
Main panel 
•  Image specification 
• Algorithm selection 
• Process initiation 
5 
VESGEN Patents Pending 
Mature, Beta-Level VESGEN 
6 https://www.asgsr.org/index.php/publications 
 VESGEN mapping of progressive GI inflammation in mice with 
probiotic inhibition of VEGF 
 
Chen, Reinecker, Parsons, Kelly et al PlosONE 2013 
8 
TheAnatomicalRecord
Advances in Integrative Anatomy and Evolutionary Biology
A
N
 O
FF
IC
IA
L 
PU
B
LI
C
A
TI
O
N
 O
F 
TH
E 
A
M
ER
IC
A
N
 A
S
S
O
C
IA
TI
O
N
 O
F 
A
N
A
TO
M
IS
TS
  
  
  
K
U
RT
 H
. 
A
LB
ER
TI
N
E 
•
 E
D
IT
O
R-
IN
-C
H
IE
F
VOL. 292  NO. 3   MARCH 2009
AR
TH
E A
N
A
TO
M
IC
A
L REC
O
RD
            M
A
RC
H
 2
0
0
9
                    V
O
L. 2
9
2
-N
O
. 3
-PA
G
ES
 3
0
9
-4
6
0
C elebrating
OVER
100 YEARS
ofExcellence in 
ANATOMICAL 
PUBLICATION
Thematic Papers:
Imaging Living
Vasculature
Coronary Vessel Network-to-Tree Transitions 
Vickerman et al, VESGEN Review, Anatomical Record A 292(3), 2009 
10 
VESGEN mapping of retinal blood vessels 
for FA-AOSLO and OCT-Angiography 
VESGEN Patents Pending 
          P Parsons with A Pinhas, R Rosen et al, Association for Research in Vision and Ophthalmology, 2014  
11 
 
VESGEN:  R&D Discovery Tool for Multidisciplinary Collaboration 
VESGEN Patents Pending 
PIV with NASA Aeronautics  
with Harvard Medical School Grav Space Biol 2012, PLoS ONE 2013 
with S Bhattacharya, R Hosamani SCR    ASGSR  2013 
with University of  Florida Grav & Space Res   2014 
with Cole Eye Institute IOVS 2010 
©Elsevier 
©University of Chicago Press 
 VESGEN 2D 
Translational Mapping and Quantification 
 of Fractal-Based Vascular Pattern 
 
 
 
•  Summary of VESGEN applications mapping and quantification of 
vascular trees and networks 
•  VESGEN software scheduled by NASA for public release in 2018 
 
 
 
 
 
 
 
 
12 
VESGEN Patent Pending 
Human Retina Mouse Retina


Vascular Patterning for Research Discovery and Technology Development

Abstract

Similar works

Full text

Available Versions

NASA Technical Reports Server