This research was aimed at measuring the effect of anagram on the students’ vocabulary size at the eight grade of MTS Islamiyah Palangka Raya. The research included in quantitative approach with Quasy Experimental Design. The population of study was the eight grade at MTS Islamiyah Palangka Raya which consisted of four classes. The writer took the sample of two classes are VIII-B as control group and VIII-A as experimental group. The sample were determined using cluster sampling technique. After getting the data from pre-test and post-test, the writer analyzed the data using SPSS 21, program to test the hypothesis stated, Based on the result of analysis, it was found that the value of ttest has higher than ttable with 2,81 and 2,02 at 5 % level of significance and ttable 2.71 at 1% level of significance with degrees of freedom = 40. It showed that the ttest was higher than the ttable. The result of testing hypothesis determined that the Alternative Hypothesis (Ha) stating that there was significant effect of anagram on the students’ vocabulary size at the eight grade of MTS Islamiyah Palangka Raya was accepted and the Null Hypothesis (Ho) stating that there was no anagram on the students’ vocabulary size at the eight grade of MTS Islamiyah Palangka Raya was rejected. It meant that there was significant effect of anagram on the students’ vocabulary size at the eight grade of MTS Islamiyah Palangka Raya. This research recommended for the students, teachers, and also for the next researchers