Relation between vertebral compressive strength and trabecular architecture is presented in terms of aging and sex. Complex in vitro medical-engineering analysis of cadaver human lumbar L1 and L2 vertebrae was executed: densitometry, CT, MRI, mechanical test and histology, in aspect of osteoporosis. In this paper the results of the mechanical test are detailed only. The compressive mechanical parameters, like limit stress and strain, proportional stress and strain, Young modulus, ductility, energy absorption capacity were determined. Morphometry analysis was based on the CT pictures. Density and diameter of trabeculae were measured. Correlation between morphometric and mechanical properties was evaluated in terms of aging, sex and bone mineral density